Lista de obras -

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction ⬇️

artículo científico publicado el 10 de julio de 1992

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

artículo científico publicado en 2002

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells

artículo científico publicado en 2004

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

artículo científico publicado en 2014

Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.

artículo científico publicado en 1998

Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein

artículo científico publicado en 2012

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

artículo científico publicado en 2019

Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs

scientific article published on 18 June 2019

Early differential molecular response of a macrophage cell line to yeast and hyphal forms of Candida albicans ⬇️

artículo científico publicado el 1 de marzo de 1992

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

artículo científico publicado en 2009

Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells ⬇️

artículo científico publicado el 1 de octubre de 1992

Human lung carcinoma cells engineered to release IL2, IL7, GM-CSF and TNF alpha ⬇️

artículo científico publicado el 1 de abril de 1996

Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage-CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1 ⬇️

artículo científico publicado el 1 de diciembre de 1992

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

artículo científico publicado en 2016

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

artículo científico publicado en 2017

Investigating the metastatic niche in melanoma: a new therapeutic opportunity?

artículo científico publicado en 2014

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

artículo científico publicado en 2016

Loss of amplification and appearance of a novel translocation site of the c-myc oncogene in HL-60 leukemia cells ⬇️

artículo científico publicado el 1 de octubre de 1991

Melanoma: targeting signaling pathways and RaLP

artículo científico publicado en 2009

Modeling cell proliferation in human acute myeloid leukemia xenografts

scientific article published on 01 September 2019

Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides 1 1Edited by J. Karn ⬇️

artículo científico publicado el 27 de junio de 1997

Molecular networks in melanoma invasion and metastasis.

artículo científico

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

artículo científico publicado en 1997

Pirin inhibits cellular senescence in melanocytic cells.

artículo científico publicado en 2011

RNAi screens identify CHD4 as an essential gene in breast cancer growth

artículo científico publicado en 2016

Retroviral gene transfer, rapid selection, and maintenance of the immature phenotype in mouse dendritic cells

artículo científico publicado en 1999

Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism

artículo científico publicado en 2001

ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

scientific article published on 13 November 2020

Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22

artículo científico publicado el 1 de abril de 1992

Suppressor macrophages in tumor-bearing mice. Inconsistency between in vivo and in vitro findings? ⬇️

artículo científico publicado el 15 de junio de 1982

Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.

artículo científico publicado en 2008

The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor

artículo científico publicado en 1997

The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 breast cancer cells

scientific article published on 18 April 2019

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

artículo científico publicado en 2004

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

artículo científico publicado en 2017

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

artículo científico publicado en 1998

Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling

artículo científico publicado en 2002

WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells

scientific article published on 21 November 2019

c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells

artículo científico publicado en 1998

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells

scientific article published on 30 May 2007

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

artículo científico publicado en 2019

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.

artículo científico publicado en 2004

Lista de obras de

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction ⬇️

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells

Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner

Bombesin-induced pancreatic regeneration in pigs is mediated by p46Shc/p52Shc and p42/p44 mitogen-activated protein kinase upregulation.

Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Development of Personalized Therapeutic Strategies by Targeting Actionable Vulnerabilities in Metastatic and Chemotherapy-Resistant Breast Cancer PDXs

Early differential molecular response of a macrophage cell line to yeast and hyphal forms of Candida albicans ⬇️

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells ⬇️

Human lung carcinoma cells engineered to release IL2, IL7, GM-CSF and TNF alpha ⬇️

Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage-CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1 ⬇️

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

Investigating the metastatic niche in melanoma: a new therapeutic opportunity?

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.

Loss of amplification and appearance of a novel translocation site of the c-myc oncogene in HL-60 leukemia cells ⬇️

Melanoma: targeting signaling pathways and RaLP

Modeling cell proliferation in human acute myeloid leukemia xenografts

Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides 1 1Edited by J. Karn ⬇️

Molecular networks in melanoma invasion and metastasis.

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

Pirin inhibits cellular senescence in melanocytic cells.

RNAi screens identify CHD4 as an essential gene in breast cancer growth

Retroviral gene transfer, rapid selection, and maintenance of the immature phenotype in mouse dendritic cells

Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism

ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22

Suppressor macrophages in tumor-bearing mice. Inconsistency between in vivo and in vitro findings? ⬇️

Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.

The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor

The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2 breast cancer cells

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling

WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells

c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.