Lista de obras -

Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron ⬇️

artículo científico publicado el 2 de mayo de 2003

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

artículo científico publicado en 2018

Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay

artículo científico publicado en 2000

Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish, Sparus aurata.

artículo científico publicado en 2000

Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development

artículo científico publicado en 2015

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis).

artículo científico publicado en 2014

Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development.

artículo científico publicado en 2012

Developmental toxicity study of lersivirine in mice.

artículo científico publicado en 2012

Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat.

artículo científico publicado en 2003

Embryo-fetal distribution of a biopharmaceutical IgG2 during rat organogenesis

artículo científico publicado en 2012

Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding

scientific article published on 11 September 2012

Estradiol-induced gene expression in largemouth bass (Micropterus salmoides).

artículo científico publicado en 2002

Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus)

artículo científico publicado en 2000

Evaluation of a novel delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats.

artículo científico publicado en 2014

Goldilocks' Determination of What New In Vivo Data are "Just Right" for Different Common Drug Development Scenarios, Part 1.

artículo científico publicado en 2016

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses.

artículo científico publicado en 2018

Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation.

artículo científico publicado en 2001

Induction of tyrosine hydroxylase by forskolin: modulation with age

artículo científico publicado en 1997

Juvenile toxicity assessment of anidulafungin in rats: an example of navigating case-by-case study design through scientific and regulatory challenges.

artículo científico publicado en 2011

Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development.

scientific article published on August 2010

Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor.

artículo científico publicado en 2014

Multiple responses in gene expression in fish treated with estrogen.

artículo científico publicado en 2001

Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics ⬇️

artículo científico publicado el 1 de septiembre de 2013

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: A combination study design in support of a Paediatric Investigation Plan ⬇️

artículo científico publicado el 16 de febrero de 2012

Object discrimination reversal as a method to assess cognitive impairment in nonhuman primate enhanced pre- and postnatal developmental (ePPND) studies: statistical power analysis.

artículo científico publicado en 2012

Placental transfer of (125)Iodinated humanized immunoglobulin G2Δa in the Sprague Dawley rat.

artículo científico publicado en 2013

Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis

artículo científico publicado en 2013

Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices.

artículo científico publicado en 2011

Reproductive toxicity assessment of sunitinib, a multitargeted receptor tyrosine kinase inhibitor, in male and female rats.

artículo científico publicado en 2012

Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development.

artículo científico publicado en 2016

Sensitive Windows of Skeletal Development in Rabbits Determined by Hydroxyurea Exposure at Different Times throughout Gestation ⬇️

artículo científico publicado el 11 de abril de 2012

Sensitivity of male reproductive endpoints in nonhuman primate toxicity studies: a statistical power analysis.

artículo científico publicado en 2013

The design of chronic toxicology studies of monoclonal antibodies: implications for the reduction in use of non-human primates.

artículo científico publicado en 2011

The placenta, transfer of immunoglobulins, and safety assessment of biopharmaceuticals in pregnancy.

artículo científico publicado en 2012

Tissue distribution of anidulafungin in neonatal rats.

artículo científico publicado en 2012

Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol.

artículo científico publicado en 2002

Lista de obras de

Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron ⬇️

Applying a weight of evidence approach to the evaluation of developmental toxicity of biopharmaceuticals

Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay

Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish, Sparus aurata.

Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development

Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis).

Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development.

Developmental toxicity study of lersivirine in mice.

Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat.

Embryo-fetal distribution of a biopharmaceutical IgG2 during rat organogenesis

Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding

Estradiol-induced gene expression in largemouth bass (Micropterus salmoides).

Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus)

Evaluation of a novel delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats.

Goldilocks' Determination of What New In Vivo Data are "Just Right" for Different Common Drug Development Scenarios, Part 1.

Immunologic effects of chronic administration of tofacitinib, a Janus kinase inhibitor, in cynomolgus monkeys and rats - Comparison of juvenile and adult responses.

Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation.

Induction of tyrosine hydroxylase by forskolin: modulation with age

Juvenile toxicity assessment of anidulafungin in rats: an example of navigating case-by-case study design through scientific and regulatory challenges.

Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development.

Morphologic, stereologic, and morphometric evaluation of the nervous system in young cynomolgus monkeys (Macaca fascicularis) following maternal administration of tanezumab, a monoclonal antibody to nerve growth factor.

Multiple responses in gene expression in fish treated with estrogen.

Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics ⬇️

Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: A combination study design in support of a Paediatric Investigation Plan ⬇️

Object discrimination reversal as a method to assess cognitive impairment in nonhuman primate enhanced pre- and postnatal developmental (ePPND) studies: statistical power analysis.

Placental transfer of (125)Iodinated humanized immunoglobulin G2Δa in the Sprague Dawley rat.

Placental transfer of Fc-containing biopharmaceuticals across species, an industry survey analysis

Preclinical safety evaluations supporting pediatric drug development with biopharmaceuticals: strategy, challenges, current practices.

Reproductive toxicity assessment of sunitinib, a multitargeted receptor tyrosine kinase inhibitor, in male and female rats.

Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development.

Sensitive Windows of Skeletal Development in Rabbits Determined by Hydroxyurea Exposure at Different Times throughout Gestation ⬇️

Sensitivity of male reproductive endpoints in nonhuman primate toxicity studies: a statistical power analysis.

The design of chronic toxicology studies of monoclonal antibodies: implications for the reduction in use of non-human primates.

The placenta, transfer of immunoglobulins, and safety assessment of biopharmaceuticals in pregnancy.

Tissue distribution of anidulafungin in neonatal rats.

Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol.