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Lista de obras de Raymond F. Schinazi

1-Benzyl-2-(1H-indol-3-yl)-5-oxopyrrolidine-2-carbonitrile ⬇️

artículo científico publicado el 4 de enero de 2008

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.

artículo científico publicado en 2017

2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions

artículo científico publicado en 2004

2′-Fluoro-4′-thio-2′,3′-unsaturated Nucleosides: Anti-HIV Activity, Resistance Profile, and Molecular Modeling Studies ⬇️

artículo científico publicado el 1 de mayo de 2003

3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.

artículo científico publicado en 2010

5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies

artículo científico publicado en 2008

5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

artículo científico publicado en 2005

A CRISPR/Cas9 approach reveals that the polymerase activity of DNA polymerase β is dispensable for HIV-1 infection in dividing and nondividing cells

artículo científico publicado en 2017

A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin

artículo científico publicado en 2016

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

artículo científico publicado en 2010

A new oxygen modification cyclooctaoxygen binds to nucleic acids as sodium crown complex

artículo científico publicado en 2016

Abundant Non-canonical dUTP Found in Primary Human Macrophages Drives Its Frequent Incorporation by HIV-1 Reverse Transcriptase ⬇️

artículo científico publicado el 31 de marzo de 2011

Acute acalculous cholecystitis during Zika virus infection in an immunocompromised patient

artículo científico publicado en 2017

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

artículo científico publicado en 2008

Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses

artículo científico publicado en 2013

Advances in nucleoside monophosphate prodrugs as anti-HCV agents ⬇️

artículo científico publicado el 1 de enero de 2010

An Efficient Route to β-d-Isoxazolidinyl Nucleosides via Diastereoselective Michael Addition of Hydroxylamine to Unsaturated Esters ⬇️

artículo científico publicado el 17 de octubre de 1997

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART

artículo científico publicado en 2014

Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels ⬇️

artículo científico publicado el 5 de junio de 2013

Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism

artículo científico publicado en 2005

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs

artículo científico publicado en 2009

Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides

scientific article published on 13 July 2009

Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia

artículo científico publicado en 2010

Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.

artículo científico publicado en 2012

Antiretroviral therapy in macrophages: implication for HIV eradication

artículo científico publicado en 2009

Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues

artículo científico publicado en 2002

Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine

artículo científico publicado en 2003

Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals

artículo científico publicado en 2010

Antiviral activity of nucleoside analogues against norovirus

artículo científico publicado en 2012

Antiviral agents derived from novel 1-adamantyl singlet nitrenes

artículo científico publicado en 2012

Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine

artículo científico publicado en 2008

Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine

artículo científico publicado en 2007

Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection

artículo científico publicado en 2007

Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells

artículo científico publicado en 2014

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase

artículo científico publicado en 2020

Approaches for the development of antiviral compounds: the case of hepatitis C virus

artículo científico publicado en 2009

Approaches to hepatitis C treatment and cure using NS5A inhibitors

scientific article published on 05 March 2014

Assessment of the relative potency of emtricitabine and lamivudine

artículo científico publicado en 2003

Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition

artículo científico publicado en 2014

Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors

artículo científico publicado en 2013

Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase

artículo científico publicado en 2012

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.

artículo científico publicado en 2016

Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate

artículo científico publicado en 2007

Cellular Pharmacology and Potency of HIV-1 Nucleoside Analogs in Primary Human Macrophages ⬇️

artículo científico publicado el 21 de diciembre de 2012

Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.

artículo científico publicado en 2003

Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells

artículo científico publicado en 2016

Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides

artículo científico publicado en 2005

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

artículo científico publicado en 2017

Chemoenzymatic Syntheses and Anti-HIV-1 Activity of Glucose−Nucleoside Conjugates as Prodrugs ⬇️

artículo científico publicado el 15 de noviembre de 2010

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis

artículo científico publicado en 2015

Chutes and ladders in hepatitis C nucleoside drug development

artículo científico publicado en 2014

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target

artículo científico publicado en 2004

Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system

artículo científico publicado en 2008

Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.

artículo científico publicado en 2009

Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans

artículo científico publicado en 2005

Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

artículo científico publicado en 2021

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques"

Cost analysis of sofosbuvir/ribavirin versus sofosbuvir/simeprevir for genotype 1 hepatitis C virus in interferon-ineligible/intolerant individuals

artículo científico publicado en 2014

Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry

artículo científico publicado en 2009

D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance

artículo científico publicado en 2007

DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants

artículo científico publicado en 2002

Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase

artículo científico publicado en 2008

Design, synthesis and evaluation of novel anti-HCV molecules that deliver intracellularly three highly potent NS5A inhibitors

artículo científico publicado en 2015

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

artículo científico publicado en 2005

Development of a novel mouse model to evaluate drug candidates against hepatitis B virus

artículo científico publicado en 2007

Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors

artículo científico publicado en 2002

Development of a population simulation model for HIV monotherapy virological outcomes using lamivudine

artículo científico publicado en 2007

Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model

artículo científico publicado en 2008

Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells

artículo científico publicado en 2015

Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus

artículo científico publicado en 2019

Discovery, characterization, and lead optimization of 7-azaindole non-nucleoside HIV-1 reverse transcriptase inhibitors

artículo científico publicado en 2016

Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites

artículo científico publicado en 2003

ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.

artículo científico publicado en 2005

Editorial overview: Antiviral strategies

scholarly article by Erik De Clercq published in June 2016

Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

scientific article published on September 2004

Efficacy and safety of 3-week response-guided triple direct-acting antiviral therapy for chronic hepatitis C infection: a phase 2, open-label, proof-of-concept study

artículo científico publicado en 2016

Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs ⬇️

artículo científico publicado el 3 de mayo de 2012

Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection ⬇️

artículo científico publicado el 29 de julio de 2011

Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies

article published in 2005

Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy

artículo científico publicado en 2005

Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

artículo científico publicado en 2006

Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme

artículo científico publicado en 2009

Enhanced antiretroviral therapy in rhesus macaques improves RT-SHIV viral decay kinetics

artículo científico publicado en 2014

Evaluation of Single and Combination Therapies with Tenofovir Disoproxil Fumarate and Emtricitabine In Vitro and in a Robust Mouse Model Supporting High Levels of Hepatitis B Virus Replication ⬇️

artículo científico publicado el 17 de septiembre de 2012

Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin

artículo científico publicado en 2012

Expression, purification, and characterization of a GII.4 norovirus protease

artículo científico publicado en 2018

Facile purification of honokiol and its antiviral and cytotoxic properties

artículo científico publicado en 2006

Food Insufficiency and Medication Adherence Among People Living with HIV/AIDS in Urban and Peri-Urban Settings ⬇️

artículo científico publicado el 1 de septiembre de 2011

From HCV To HBV Cure

artículo científico publicado en 2017

HCV direct-acting antiviral agents: the best interferon-free combinations

artículo científico publicado en 2014

HIV latency reversal research and the potential effects on the central nervous system: is concern warranted?

artículo científico publicado en 2016

HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).

artículo científico publicado en 2003

Hepatitis B virus resistance to lamivudine and its clinical implications

artículo científico publicado en 2002

Hepatitis B virus transgenic severe combined immunodeficient mouse model of acute and chronic liver disease

artículo científico publicado en 2004

Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection

artículo científico publicado en 2004

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

article

Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients

artículo científico publicado en 2015

In silico study supports the efficacy of a reduced dose regimen for stavudine ⬇️

artículo científico publicado el 22 de agosto de 2011

In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase

artículo científico publicado en 2005

In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine

artículo científico publicado en 2005

In-vitro phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitor S/GSK1349572.

artículo científico publicado en 2010

Inactivation of SARS-CoV-2 and COVID-19 Patient Samples for Contemporary Immunology and Metabolomics Studies

artículo científico publicado en 2022

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease

artículo científico publicado en 2017

Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

artículo científico publicado en 2006

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

artículo científico publicado en 2004

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate

artículo científico publicado en 2002

Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma

artículo científico publicado en 2007

Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase

artículo científico publicado en 2002

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts

artículo científico publicado en 2018

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.

artículo científico publicado en 2004

Jak Inhibitors Modulate Production of Replication-Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells

artículo científico

Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

artículo científico publicado en 2014

Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals

artículo científico publicado en 2009

Ligand similarity guided receptor selection enhances docking accuracy and recall for non-nucleoside HIV reverse transcriptase inhibitors

artículo científico publicado en 2015

Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction

artículo científico publicado en 2008

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

artículo científico publicado en 2005

Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.

artículo científico publicado en 2003

Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

artículo científico publicado en 2007

Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine

artículo científico publicado en 2005

Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach

artículo científico publicado en 2003

Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase

scientific article published on 09 June 2009

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses

artículo científico publicado en 2015

Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.

artículo científico publicado en 2016

Metabolism of Nucleosides and Nucleotides Prodrugs

artículo científico publicado en 2017

Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells

artículo científico publicado en 2004

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

artículo científico publicado en 2016

Mobile Health Intervention to Reduce HIV Transmission: A Randomized Trial of Behaviorally Enhanced HIV Treatment as Prevention (B-TasP).

artículo científico publicado en 2018

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity ⬇️

artículo científico publicado en 2006

Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

artículo científico publicado en 2006

Molecular docking and antiviral activity of N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides.

artículo científico publicado en 2015

Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach

artículo científico publicado en 2002

Molecular mechanism of HIV-1 resistance to 3'-azido-2',3'-dideoxyguanosine

artículo científico publicado en 2013

Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity

artículo científico publicado en 2008

Monthly Unannounced Pill Counts for Monitoring HIV Treatment Adherence: Tests for Self-Monitoring and Reactivity Effects ⬇️

artículo científico publicado el 1 de noviembre de 2010

Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

artículo científico publicado en 2002

N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity

artículo científico publicado en 2003

New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. ⬇️

artículo científico publicado en 2003

Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase

artículo científico publicado en 2004

Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase

artículo científico publicado en 2017

PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity

artículo científico publicado en 2006

Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans.

artículo científico publicado en 1998

Pharmacokinetics and Placental Transfer of Elvitegravir, Dolutegravir, and Other Antiretrovirals during Pregnancy

artículo científico publicado en 2017

Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys

artículo científico publicado en 2007

Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys

artículo científico publicado en 2007

Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys

artículo científico publicado en 2005

Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys

artículo científico publicado en 2005

Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses

artículo científico publicado en 2006

Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha

artículo científico publicado en 2005

Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies

artículo científico publicado en 2005

Polyoxometalates in Medicine

artículo científico publicado en 1998

Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.

artículo científico publicado en 2004

Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors

artículo científico publicado en 2012

Pre-steady state kinetic analysis of HIV-1 reverse transcriptase for non-canonical ribonucleoside triphosphate incorporation and DNA synthesis from ribonucleoside-containing DNA template

artículo científico publicado en 2014

Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase

artículo científico publicado en 2012

Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.

artículo científico publicado en 2007

Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly ⬇️

artículo científico publicado el 19 de agosto de 2013

Predicting Zika virus structural biology: Challenges and opportunities for intervention

artículo científico publicado en 2016

Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir

artículo científico publicado en 2008

Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase

artículo científico publicado en 2003

Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

artículo científico publicado en 2003

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

artículo científico publicado en 2015

Prodrug strategies for improved efficacy of nucleoside antiviral inhibitors

artículo científico publicado en 2013

Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.

artículo científico publicado en 2005

Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome

artículo científico publicado en 2010

Randomized Clinical Trial of HIV Treatment Adherence Counseling Interventions for People Living With HIV and Limited Health Literacy ⬇️

artículo científico publicado el 1 de mayo de 2013

Randomized Factorial Trial of Phone-Delivered Support Counseling and Daily Text Message Reminders for HIV Treatment Adherence

artículo científico publicado en 2016

Randomized, double-blind, multicenter safety and efficacy study of rifalazil compared with azithromycin for treatment of uncomplicated genital Chlamydia trachomatis infection in women

artículo científico publicado en 2014

Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri

artículo científico publicado en 2004

Replication-dependent 65R-->K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V.

artículo científico publicado en 2004

Residual viremia in an RT-SHIV rhesus macaque HAART model marked by the presence of a predominant plasma clone and a lack of viral evolution

artículo científico publicado en 2014

Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection

artículo científico publicado en 2015

Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.

artículo científico publicado en 2014

Retrovirus reverse transcriptases containing a modified YXDD motif

artículo científico publicado en 2005

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

artículo científico publicado en 2003

Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages

artículo científico publicado en 2010

Ribonucleotide incorporation in yeast genomic DNA shows preference for cytosine and guanosine preceded by deoxyadenosine

artículo científico publicado en 2020

Role of Marine Natural Products in the Genesis of Antiviral Agents

artículo científico publicado en 2015

Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.

artículo científico publicado en 2014

SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells

artículo científico publicado en 2016

Scaleable processes for the synthesis of (−)-β-d-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (−)-β-d-2-aminopurine dioxolane (APD) ⬇️

artículo científico publicado el 16 de mayo de 2012

Selection and Characterization of HIV-1 with a Novel S68 Deletion in Reverse Transcriptase ⬇️

artículo científico publicado el 28 de febrero de 2011

Sexual HIV Transmission and Antiretroviral Therapy: A Prospective Cohort Study of Behavioral Risk Factors Among Men and Women Living with HIV/AIDS ⬇️

artículo científico publicado el 1 de agosto de 2011

Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes

artículo científico publicado en 2007

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

scholarly article by Maud Mavigner et al published 15 September 2018 in Journal of Virology

Simian immunodeficiency virus macaque models of HIV latency

artículo científico publicado en 2011

Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay

artículo científico publicado en 2009

Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry

artículo científico

Sonication-Assisted Synthesis of(E)-2-Methyl-but-2-enyl Nucleoside Phosphonate Prodrugs

Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides

artículo científico publicado en 2002

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

artículo científico publicado en 2019

Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents

artículo científico publicado en 2002

Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs ⬇️

artículo científico publicado el 13 de septiembre de 2011

Substrates and Inhibitors of SAMHD1.

artículo científico publicado en 2017

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

artículo científico publicado en 2014

Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

artículo científico publicado en 2005

Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides ⬇️

artículo científico publicado el 1 de abril de 2011

Synthesis and Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of 7-Deazaneplanocin A Analogues in Vitro

artículo científico publicado en 2009

Synthesis and Antiviral Evaluation of 2′,3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-D-arabinofuranosyl Pyrimidine Nucleosides ⬇️

artículo científico publicado el 1 de mayo de 2003

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

artículo científico publicado en 2015

Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives

artículo científico publicado en 2005

Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs

artículo científico publicado en 2017

Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs

artículo científico publicado en 2007

Synthesis and anti-HIV activity of D- and L-thietanose nucleosides

artículo científico publicado en 2006

Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides

artículo científico publicado en 2005

Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs.

artículo científico publicado en 2009

Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.

artículo científico publicado en 2013

Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones

artículo científico publicado en 2005

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system

artículo científico publicado en 2005

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

artículo científico publicado en 2005

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates ⬇️

artículo científico publicado el 29 de septiembre de 2011

Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.

artículo científico publicado en 2005

Synthesis and antiviral activity of purine 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl nucleosides

artículo científico publicado en 2009

Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs

artículo científico publicado en 2014

Synthesis and antiviral evaluation of 2′,2′,3′,3′-tetrafluoro nucleoside analogs

artículo científico publicado en 2017

Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates

artículo científico publicado en 2016

Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors

artículo científico publicado en 2017

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents

artículo científico publicado en 2007

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors ⬇️

artículo científico publicado el 29 de marzo de 2012

Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors

scientific article published on 16 November 2006

Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

artículo científico publicado en 2013

Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents

scientific article published on 03 April 2007

Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

artículo científico publicado en 2009

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors ⬇️

artículo científico publicado el 29 de marzo de 2013

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors ⬇️

artículo científico publicado el 13 de febrero de 2013

Synthesis and evaluation of novel potent HCV NS5A inhibitors ⬇️

artículo científico publicado el 24 de mayo de 2012

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides

artículo científico publicado en 2005

Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine

artículo científico publicado en 2002

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives

artículo científico publicado en 2005

Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination

artículo científico publicado en 2017

Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.

artículo científico publicado en 2003

Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.

artículo científico publicado en 2005

Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides ⬇️

artículo científico publicado el 23 de agosto de 2012

Synthesis of Cyclopentanyl Carbocyclic 5-Fluorocytosine ((−)-5-Fluorocarbodine) Using a Facially Selective Hydrogenation Approach ⬇️

artículo científico publicado el 26 de diciembre de 2012

Synthesis of Dihydroisoxazole Nucleoside and Nucleotide Analogs ⬇️

artículo científico publicado el 10 de enero de 1997

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents

artículo científico publicado en 2005

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity

artículo científico publicado en 2004

Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture

artículo científico publicado en 2004

Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases

artículo científico publicado en 2015

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase

artículo científico publicado en 2015

Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent

artículo científico publicado en 2004

Synthesis of neplanocin F analogues as potential antiviral agents

artículo científico publicado en 2006

Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution

scientific article published on 01 July 2004

Synthesis of nucleoside phosphate and phosphonate prodrugs

artículo científico publicado en 2014

Synthesis of oxathiolane imidazole nucleosides

artículo científico publicado en 2002

Synthesis of purine modified 2′-C-methyl nucleosides as potential anti-HCV agents ⬇️

artículo científico publicado el 20 de septiembre de 2011

Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector

artículo científico publicado en 2017

Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides

artículo científico publicado en 2003

Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides

artículo científico publicado en 2005

Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases

artículo científico publicado en 2009

Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides ⬇️

artículo científico publicado el 30 de mayo de 2011

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

artículo científico publicado en 2011

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

artículo científico publicado en 2007

Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors

artículo científico publicado en 2013

Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides ⬇️

artículo científico publicado el 23 de septiembre de 2012

Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents

artículo científico publicado en 2004

Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents

artículo científico publicado en 2004

Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.

artículo científico publicado en 2011

Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

artículo científico publicado en 2005

The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase ⬇️

artículo científico publicado el 6 de junio de 2011

The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents ⬇️

artículo científico publicado el 1 de enero de 2012

The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model

artículo científico publicado en 2016

The Synthesis and Biological Evaluation of Novel Bridging Nucleoside Analogues ⬇️

artículo científico publicado el 1 de febrero de 2002

The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells

artículo científico publicado en 2005

Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases

artículo científico publicado en 2004

Tissue disposition of 5-o-carboranyluracil--a novel agent for the boron neutron capture therapy of prostate cancer

artículo científico publicado en 2004

Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities

artículo científico publicado en 2016

Towards HBV curative therapies

artículo científico publicado en 2018

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

artículo científico publicado en 2015

Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

artículo científico publicado en 2005

Treatment as prevention and cure towards global eradication of hepatitis C virus

artículo científico publicado en 2013

Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?

artículo científico publicado en 2018

Universal Profiling of HIV-1 Pol for Genotypic Study and Resistance Analysis Across Subtypes ⬇️

artículo científico publicado el 1 de enero de 2011

Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet ⬇️

artículo científico publicado el 10 de enero de 2012

Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial

artículo científico publicado en 2015

Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.

artículo científico publicado en 2014

Viral Decay Kinetics in the Highly Active Antiretroviral Therapy-Treated Rhesus Macaque Model of AIDS ⬇️

artículo científico publicado el 23 de julio de 2010

Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks

artículo científico publicado en 2002

Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS

artículo científico publicado en 2009

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase

artículo científico publicado en 2002

William H Prusoff Dies at 90 – A Renaissance Man that Revolutionized the Treatment of Herpesviruses and HIV ⬇️

artículo científico publicado el 4 de julio de 2011

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

artículo científico publicado en 2017

dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.

artículo científico publicado en 2014

l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance

artículo científico publicado en 2003

β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms

artículo científico publicado en 2015

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