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A novel cinnamic acid derivative that inhibits Cdc25 dual-specificity phosphatase activity.

artículo científico publicado en 2005

A suppressor of mutations in the region adjacent to iterons of pSC101 ori.

artículo científico publicado en 1997

Acquired resistance to trastuzumab/pertuzumab or to T-DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728

scientific article published on 05 April 2020

Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways

artículo científico publicado en 2019

Efficacy and safety of TAS-116, an oral inhibitor of heat shock protein 90, in patients with metastatic or unresectable gastrointestinal stromal tumour refractory to imatinib, sunitinib and regorafenib: a phase II, single-arm trial

scientific article published on 16 September 2019

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

artículo científico publicado en 2006

First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors

artículo científico publicado en 2019

Minimal essential origin of plasmid pSC101 replication: requirement of a region downstream of iterons.

artículo científico publicado en 1993

Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

artículo científico publicado en 2020

Substrate phage as a tool to identify novel substrate sequences of proteases.

artículo científico publicado en 2001

TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models.

artículo científico publicado en 2014

TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models

scientific article published on 20 February 2019

TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models

scientific article published on 15 May 2019

dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells

artículo científico publicado en 2020

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

artículo científico publicado en 2007

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