Lista de obras - John Whitelock - Dominio Público Uruguay

A central function for perlecan in skeletal muscle and cardiovascular development

artículo científico publicado en 2008

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

artículo científico publicado en 2015

Altered decorin leads to disrupted endothelial cell function: a possible mechanism in the pathogenesis of fetal growth restriction?

artículo científico publicado en 2014

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

artículo científico publicado en 1998

Bioengineered heparin: is there a future for this form of the successful therapeutic?

artículo científico publicado en 2014

Bioengineered human heparin with anticoagulant activity.

artículo científico publicado en 2016

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

artículo científico publicado en 2019

Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

artículo científico publicado en 2015

Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.

artículo científico publicado en 2018

Cellular uptake and reactive oxygen species modulation of cerium oxide nanoparticles in human monocyte cell line U937.

artículo científico publicado en 2012

Characterization and purification of glycosaminoglycans from crude biological samples.

artículo científico publicado en 2007

Colocalization in vivo and association in vitro of perlecan and elastin.

artículo científico publicado en 2011

Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.

artículo científico publicado en 2014

Decreased placental glypican expression is associated with human fetal growth restriction

artículo científico publicado en 2018

Diverse cell signaling events modulated by perlecan.

artículo científico publicado en 2008

Effects of base material, plasma proteins and FGF2 on endothelial cell adhesion and growth

artículo científico publicado en 2002

Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins.

artículo científico publicado en 2001

Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells

artículo científico publicado en 2016

Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism

artículo científico publicado en 2011

Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling

artículo científico publicado en 2014

Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells

artículo científico publicado en 2017

Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography.

artículo científico publicado en 2014

Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives.

artículo científico publicado en 2017

Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions

artículo científico publicado en 2015

Graphitized carbon LC-MS characterization of the chondroitin sulfate oligosaccharides of aggrecan

artículo científico publicado en 2007

Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair

artículo científico publicado en 2018

Heparan sulfate proteoglycans in healthy and diseased systems

artículo científico publicado en 2011

Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.

artículo científico publicado en 2010

Heparin fails to inhibit the proliferation of human vascular smooth muscle cells in the presence of human serum

artículo científico publicado en 1998

Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

artículo científico publicado en 1999

Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity

artículo científico publicado en 2012

Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts

artículo científico publicado en 2016

Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms ⬇️

artículo científico publicado en 2019

INHIBITION OF PHENOTYPE MODULATION, GROWTH, AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS BY A GUANOSINE-RICH 30-MER PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE

scientific article published on 01 September 1997

Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: role of type V collagen

scientific article published on 01 November 1998

Isolation and purification of proteoglycans.

artículo científico publicado en 2002

LTBP-2 has multiple heparin/heparan sulfate binding sites.

artículo científico publicado en 2010

Mast Cells Produce a Unique Chondroitin Sulfate Epitope

artículo científico publicado en 2015

Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing.

artículo científico publicado en 2012

Matrix components and scaffolds for sustained islet function.

artículo científico publicado en 2011

Mechanisms and consequences of oxidative damage to extracellular matrix.

artículo científico

Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration

artículo científico publicado en 2017

Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications.

artículo científico publicado en 2017

Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells.

artículo científico publicado en 2014

Oxidative damage to extracellular matrix and its role in human pathologies.

artículo científico publicado en 2008

Pathogenesis of abdominal aortic aneurysms: possible role of differential production of proteoglycans by smooth muscle cells

artículo científico publicado en 1998

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing.

artículo científico publicado en 2017

Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint

scientific article published on 17 June 2005

Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin

artículo científico publicado en 2016

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.

artículo científico publicado en 2005

Perlecan immunolocalizes to perichondrial vessels and canals in human fetal cartilaginous primordia in early vascular and matrix remodeling events associated with diarthrodial joint development.

artículo científico publicado en 2004

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.

artículo científico publicado en 2009

Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling

artículo científico publicado en 2003

Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.

artículo científico publicado en 2008

Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine.

artículo científico publicado en 2003

Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN

scientific journal article

Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains

artículo científico publicado en 2010

Perspectives on the use of biomaterials to store platelets for transfusion

artículo científico publicado en 2016

Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation.

artículo científico publicado en 2017

Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

artículo científico publicado en 2015

Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan.

artículo científico publicado en 2017

Recombinant production of proteoglycans and their bioactive domains ⬇️

artículo científico publicado el 18 de marzo de 2013

Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications.

artículo científico publicado en 2016

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1 ⬇️

artículo científico publicado el 9 de septiembre de 2010

Specific affinity depletion of cell adhesion molecules and growth factors from serum

artículo científico publicado en 2001

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors

artículo científico publicado en 2017

Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line.

artículo científico publicado en 2012

Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells.

artículo científico publicado en 2018

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.

artículo científico publicado en 2017

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.

artículo científico publicado en 2016

The cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factors ⬇️

artículo científico publicado el 3 de marzo de 2012

The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth

artículo científico publicado en 1997

The glycosylation of human synovial lubricin: implications for its role in inflammation

article

The identification, purification and characterisation of an inhibitor of collagenase (20K) produced by neoplastic epithelial cells ⬇️

artículo científico publicado el 23 de enero de 1991

The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan

artículo científico publicado en 2013

The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins.

artículo científico publicado en 2011

The modulation of platelet and endothelial cell adhesion to vascular graft materials by perlecan

artículo científico publicado en 2009

The multifaceted roles of perlecan in fibrosis

scientific article published on 20 February 2018

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.

artículo científico publicado en 2014

The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages

artículo científico publicado en 2006

Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1.

artículo científico

Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression

artículo científico publicado en 1993

Use of graphitised carbon negative ion LC–MS to analyse enzymatically digested glycosaminoglycans

artículo científico publicado en 2005

Lista de obras de John Whitelock

A central function for perlecan in skeletal muscle and cardiovascular development

Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

Altered decorin leads to disrupted endothelial cell function: a possible mechanism in the pathogenesis of fetal growth restriction?

Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo

Bioengineered heparin: is there a future for this form of the successful therapeutic?

Bioengineered human heparin with anticoagulant activity.

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.

Cellular uptake and reactive oxygen species modulation of cerium oxide nanoparticles in human monocyte cell line U937.

Characterization and purification of glycosaminoglycans from crude biological samples.

Colocalization in vivo and association in vitro of perlecan and elastin.

Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.

Decreased placental glypican expression is associated with human fetal growth restriction

Diverse cell signaling events modulated by perlecan.

Effects of base material, plasma proteins and FGF2 on endothelial cell adhesion and growth

Electrophoretic, biosensor, and bioactivity analyses of perlecans of different cellular origins.

Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells

Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism

Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling

Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells

Fibrinogen adsorption and platelet adhesion to silica surfaces with stochastic nanotopography.

Glycosaminoglycan and Proteoglycan-Based Biomaterials: Current Trends and Future Perspectives.

Glycosaminoglycan functionalized nanoparticles exploit glycosaminoglycan functions

Graphitized carbon LC-MS characterization of the chondroitin sulfate oligosaccharides of aggrecan

Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair

Heparan sulfate proteoglycans in healthy and diseased systems

Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.

Heparin fails to inhibit the proliferation of human vascular smooth muscle cells in the presence of human serum

Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells.

Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity

Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts

Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms ⬇️

INHIBITION OF PHENOTYPE MODULATION, GROWTH, AND MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS BY A GUANOSINE-RICH 30-MER PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE

Inhibition of endothelial cell adhesion and proliferation by extracellular matrix from vascular smooth muscle cells: role of type V collagen

Isolation and purification of proteoglycans.

LTBP-2 has multiple heparin/heparan sulfate binding sites.

Mast Cells Produce a Unique Chondroitin Sulfate Epitope

Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing.

Matrix components and scaffolds for sustained islet function.

Mechanisms and consequences of oxidative damage to extracellular matrix.

Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degeneration

Optimization of bioengineered heparin/heparan sulfate production for therapeutic applications.

Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells.

Oxidative damage to extracellular matrix and its role in human pathologies.

Pathogenesis of abdominal aortic aneurysms: possible role of differential production of proteoglycans by smooth muscle cells

Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing.

Perlecan displays variable spatial and temporal immunolocalisation patterns in the articular and growth plate cartilages of the ovine stifle joint

Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.

Perlecan immunolocalizes to perichondrial vessels and canals in human fetal cartilaginous primordia in early vascular and matrix remodeling events associated with diarthrodial joint development.

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.

Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling

Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.

Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine.

Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN

Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains

Perspectives on the use of biomaterials to store platelets for transfusion

Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation.

Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk

Recombinant Domain V of Human Perlecan Is a Bioactive Vascular Proteoglycan.

Recombinant production of proteoglycans and their bioactive domains ⬇️

Silk biomaterials functionalized with recombinant domain V of human perlecan modulate endothelial cell and platelet interactions for vascular applications.

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1 ⬇️

Specific affinity depletion of cell adhesion molecules and growth factors from serum

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors

Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line.

Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells.

The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies.

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.

The cartilage matrix molecule components produced by human foetal cartilage rudiment cells within scaffolds and the role of exogenous growth factors ⬇️

The effect of human endothelial cell-derived proteoglycans on human smooth muscle cell growth

The glycosylation of human synovial lubricin: implications for its role in inflammation

The identification, purification and characterisation of an inhibitor of collagenase (20K) produced by neoplastic epithelial cells ⬇️

The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan

The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins.

The modulation of platelet and endothelial cell adhesion to vascular graft materials by perlecan

The multifaceted roles of perlecan in fibrosis

The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.