Filtros de búsqueda

Lista de obras de

17-Hydroxy Wortmannin Restores TRAIL's Response by Ameliorating Increased Beclin 1 Level and Autophagy Function in TRAIL-Resistant Colon Cancer Cells

scientific article published on 15 May 2019

5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2

A 1536-well cAMP assay for Gs- and Gi-coupled receptors using enzyme fragmentation complementation.

artículo científico publicado en 2004

A High-Throughput Assay for Developing Inhibitors of PhoP, a Virulence Factor of Mycobacterium tuberculosis

artículo científico publicado en 2016

A High-Throughput, Multi-Cell Phenotype Assay for the Identification of Novel Inhibitors of Chemotaxis/Migration

artículo científico publicado en 2016

A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

artículo científico publicado en 2016

A cell-based PDE4 assay in 1536-well plate format for high-throughput screening

artículo científico publicado en 2008

A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase

artículo científico publicado en 2006

A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity

artículo científico publicado en 2002

A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture

artículo científico publicado en 2015

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

artículo científico publicado en 2011

A high throughput screening assay system for the identification of small molecule inhibitors of gsp

artículo científico publicado en 2014

A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions.

artículo científico publicado en 2013

A high-throughput screening assay for determining cellular levels of total tau protein

artículo científico publicado en 2013

A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans

artículo científico publicado en 2013

A high-throughput sphingomyelinase assay using natural substrate.

artículo científico publicado en 2012

A homogenous luminescence assay reveals novel inhibitors for giardia lamblia carbamate kinase

artículo científico publicado en 2012

A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.

artículo científico publicado en 2008

A multiplex calcium assay for identification of GPCR agonists and antagonists

artículo científico publicado en 2010

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

artículo científico publicado en 2009

A new resorufin-based alpha-glucosidase assay for high-throughput screening

artículo científico publicado en 2009

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

artículo científico publicado en 2015

A phenotypic compound screening assay for lysosomal storage diseases

artículo científico publicado en 2013

A quantitative high throughput assay for identifying gametocytocidal compounds

artículo científico publicado en 2013

A robotic platform for quantitative high-throughput screening

artículo científico publicado en 2008

A short-incubation reporter-gene assay for high-throughput screening of estrogen receptor-alpha antagonists

artículo científico publicado en 2005

Advancing precision medicine with personalized drug screening

artículo científico publicado en 2018

An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction

artículo científico publicado en 2009

An alternative direct compound dispensing method using the HP D300 digital dispenser

artículo científico publicado en 2013

Analytical Characterization of Methyl-β-Cyclodextrin for Pharmacological Activity to Reduce Lysosomal Cholesterol Accumulation in Niemann-Pick Disease Type C1 Cells.

artículo científico publicado en 2017

Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells

artículo científico publicado en 2005

Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays

artículo científico publicado en 2004

Automated high-content screening for compounds that disassemble the perinucleolar compartment

artículo científico publicado en 2009

Calcium channels in smooth muscle. Properties and regulation

artículo científico publicado en 1989

Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition

artículo científico publicado en 2009

Cell-based no-wash fluorescence assays for compound screens using a fluorescence cytometry plate reader

artículo científico publicado en 2020

Chemical signatures and new drug targets for gametocytocidal drug development

artículo científico publicado en 2014

Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease

artículo científico publicado en 2014

Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format

scientific article published on 11 July 2008

Compound Management for Quantitative High-Throughput Screening

artículo científico publicado en 2008

Continuous versus intermittent nitroglycerin administration in experimental heart failure: vascular relaxation and radioligand binding to adrenoceptors and ion channels

artículo científico publicado en 1993

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

artículo científico publicado en 2013

Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens

artículo científico publicado en 2013

Discovery and Development of Small Molecules That Reduce PNC Prevalence

Discovery of Small Molecule Influenza Virus NS1 Antagonist

Discovery of a novel noniminosugar acid α glucosidase chaperone series

artículo científico publicado en 2012

Discovery of novel antigiardiasis drug candidates

artículo científico publicado en 2014

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

artículo científico publicado en 2015

Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators

artículo científico publicado en 2011

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase

Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1)

Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists

Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists

artículo científico publicado en 2014

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase

artículo científico publicado en 2012

Discovery, synthesis, and biological evaluation of novel SMN protein modulators

artículo científico publicado en 2011

Disease models for the development of therapies for lysosomal storage diseases

artículo científico publicado en 2016

Drug combination therapy increases successful drug repositioning

artículo científico publicado en 2016

Drug repurposing screens and synergistic drug-combinations for infectious diseases

artículo científico

ERK Regulates HIF1α-Mediated Platinum Resistance by Directly Targeting PHD2 in Ovarian Cancer

scientific article published on 08 July 2019

ERK and β-arrestin interaction: a converging point of signaling pathways for multiple types of cell surface receptors

artículo científico publicado en 2014

Editorial

artículo científico publicado en 2008

Elabela-apelin receptor signaling pathway is functional in mammalian systems

artículo científico publicado en 2015

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.

artículo científico publicado en 2018

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

artículo científico publicado en 2010

Evaluation of Cholesterol Reduction Activity of Methyl-β-cyclodextrin Using Differentiated Human Neurons and Astrocytes ⬇️

artículo científico publicado el 24 de agosto de 2012

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity

artículo científico publicado en 2011

Fabry disease - current treatment and new drug development

artículo científico publicado en 2010

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

artículo científico publicado en 2006

Generation of an induced pluripotent stem cell line (TRNDi030-A) from a patient with Farber disease carrying a homozygous p. Y36C (c. 107 A>G) mutation in ASAH1

artículo científico publicado en 2021

HTS for Identification of Inhibitors against the ERK Signaling Pathway using a Homogenous Cell-based Assay

High throughput assay technologies for ion channel drug discovery.

artículo científico publicado en 2004

High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1

artículo científico publicado en 2016

High throughput screening for SMA

High throughput screening for inhibitors of alpha-galactosidase

artículo científico publicado en 2010

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase

artículo científico publicado en 2012

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model

artículo científico publicado en 2012

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

artículo científico publicado en 2016

High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells

artículo científico publicado en 2015

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

artículo científico publicado en 2015

High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines

artículo científico publicado en 2013

High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements

artículo científico publicado en 2010

High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors.

artículo científico publicado en 2004

High-throughput screening assays for the identification of chemical probes

artículo científico publicado en 2007

High-throughput screening of 11beta-hydroxysteroid dehydrogenase type 1 in scintillation proximity assay format

artículo científico publicado en 2005

High-throughput viability assay using an autonomously bioluminescent cell line with a bacterial Lux reporter

artículo científico publicado en 2014

Human recombinant lysosomal β-Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay-Sachs fibroblasts

artículo científico publicado en 2020

Identification and Characterization of Small Molecule Functional Antagonists of the CCR1 Chemokine Receptor ⬇️

artículo científico publicado el 19 de junio de 1998

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

artículo científico publicado en 2013

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

artículo científico publicado en 2017

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

artículo científico publicado en 2014

Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines

Identification of HDAC Inhibitors Using a Cell-Based HDAC I/II Assay

artículo científico publicado en 2016

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1

Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 2

Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

artículo científico publicado en 2016

Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists

Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor

Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists

artículo científico publicado en 2013

Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity

artículo científico publicado en 2012

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction

artículo científico publicado en 2012

Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay

artículo científico publicado en 2015

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

artículo científico publicado en 2011

Identification of small molecule antagonists of the human mas-related gene-X1 receptor

artículo científico publicado en 2006

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay

artículo científico publicado en 2012

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

artículo científico publicado en 2016

In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents

artículo científico publicado en 2016

Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice

artículo científico publicado en 1997

Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A

artículo científico publicado en 2016

Induced pluripotent stem cells for neural drug discovery

artículo científico publicado en 2019

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

artículo científico publicado en 2013

Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide

artículo científico publicado en 2014

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

artículo científico publicado en 2015

Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction

artículo científico publicado en 2013

Interactions of analogs of the 1,4-dihydropyridine tiamdipine in cardiac and smooth muscle

artículo científico publicado en 1991

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects

artículo científico publicado en 2014

ML223: A Small Molecule Probe With In Vivo Activity Against Acute Myeloid Leukemia Subtype M4Eo

artículo científico publicado en 2013

ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice

artículo científico publicado en 2016

Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs

artículo científico publicado en 2014

Maduramicin Rapidly Eliminates Malaria Parasites and Potentiates the Gametocytocidal Activity of the Pyrazoleamide PA21A050.

artículo científico publicado en 2015

Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride

artículo científico publicado en 2013

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

artículo científico publicado en 2018

Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.

artículo científico publicado en 2017

Miniaturization of a hepatitis C virus RNA polymerase assay using a -102 degrees C cooled CCD camera-based imaging system

artículo científico publicado en 2001

Mitochondrial DNA damage by bleomycin induces AML cell death

artículo científico publicado en 2015

Modeling CNS Involvement in Pompe Disease Using Neural Stem Cells Generated from Patient-Derived Induced Pluripotent Stem Cells

artículo científico publicado en 2020

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

artículo científico publicado en 2016

Multi-gram scale synthesis of FR180204.

artículo científico publicado en 2009

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease

artículo científico publicado en 2007

Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease

artículo científico publicado en 2018

Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses

artículo científico publicado en 2018

Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics

artículo científico publicado en 2017

Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy

artículo científico publicado en 2014

Non-iminosugar glucocerebrosidase small molecule chaperones

artículo científico publicado en 2011

Novel Cell-Based Hepatitis C Virus Infection Assay for Quantitative High-Throughput Screening of Anti-Hepatitis C Virus Compounds.

artículo científico publicado en 2014

Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds

artículo científico publicado en 2013

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

artículo científico publicado en 2017

Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease

artículo científico publicado en 2011

One-Step Seeding of Neural Stem Cells with Vitronectin-Supplemented Medium for High-Throughput Screening Assays

artículo científico publicado en 2016

Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening

artículo científico publicado en 2008

Pharmacologic and radioligand binding studies of 1,4-dihydropyridines in rat cardiac and vascular preparations: stereoselectivity and voltage dependence of antagonist and activator interactions

artículo científico publicado en 1992

Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations

artículo científico publicado en 1991

Phenotypic screens as a renewed approach for drug discovery

artículo científico publicado en 2013

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts

scientific article published on 01 December 2019

Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents

artículo científico publicado en 2011

Plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice

artículo científico publicado en 2012

Potential-dependent interactions of nitrendipine and related 1,4-dihydropyridines in functional smooth muscle preparations

artículo científico publicado en 1988

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

artículo científico publicado en 2009

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

artículo científico publicado en 2008

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

artículo científico publicado en 2006

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

artículo científico publicado en 2020

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria

artículo científico publicado en 2016

Rapid identification of antifungal compounds against Exserohilum rostratum using high throughput drug repurposing screens

artículo científico publicado en 2013

Repurposing a novel parathyroid hormone (PTH) analog to treat hypoparathyroidism

artículo científico publicado en 2017

Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.

artículo científico publicado en 2015

SMN Modulator ML372 Increases SMN Protein Abundance, Body Weight, Lifespan, and Rescues Motor Function in SMNΔ7 SMA Mice

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy

artículo científico publicado en 2017

Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation

artículo científico publicado en 2003

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor

artículo científico publicado en 2010

Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells.

artículo científico publicado en 2018

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

artículo científico publicado en 2015

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

artículo científico publicado en 2009

Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram

artículo científico publicado en 2014

Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders

artículo científico publicado en 2019

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

artículo científico publicado en 2013

Synergistic drug combination effectively blocks Ebola virus infection

artículo científico publicado en 2016

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

artículo científico publicado en 2009

Synthetic organic ligands active at voltage-gated calcium channels

artículo científico publicado en 1991

Targeting Wolman Disease and Cholesteryl Ester Storage Disease: Disease Pathogenesis and Therapeutic Development

artículo científico publicado en 2017

The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

artículo científico publicado en 2020

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

scientific article published on 21 May 2020

The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists

artículo científico publicado en 2011

The interactions of 1,4-dihydropyridines bearing a 2-(2-aminoethylthio)methyl substituent at voltage-dependent Ca2+ channels of smooth muscle, cardiac muscle and neuronal tissues

artículo científico publicado en 1990

The pilot phase of the NIH Chemical Genomics Center

artículo científico publicado en 2009

Thermodynamic and kinetic aspects of agonist and antagonist binding to 1,4-dihydropyridine receptors

artículo científico publicado en 1991

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

artículo científico publicado en 2007

Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines

artículo científico publicado en 2016

Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.

artículo científico publicado en 2012

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders

artículo científico publicado en 2012

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda