Lista de obras -

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

artículo científico publicado en 2011

A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

artículo científico publicado en 2013

A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals

artículo científico publicado en 2010

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

artículo científico publicado en 2012

A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV.

artículo científico

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

artículo científico publicado en 2015

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

artículo científico publicado en 2003

Anti-HIV B Cell lines as candidate vaccine biosensors

artículo científico publicado en 2012

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

artículo científico publicado en 2015

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

artículo científico publicado en 2012

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses ⬇️

artículo científico publicado el 13 de julio de 2012

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

artículo científico publicado en 2013

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

artículo científico publicado en 2016

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

artículo científico publicado en 2014

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

artículo científico publicado en 2009

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

artículo científico publicado en 2009

CXCL13 is a plasma biomarker of germinal center activity

artículo científico publicado en 2016

Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies

artículo científico publicado en 2003

Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization

artículo científico publicado en 2002

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch

artículo científico publicado en 2016

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

artículo científico publicado en 2009

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

artículo científico publicado en 2003

Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

artículo científico publicado en 2003

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo ⬇️

artículo científico publicado el 25 de octubre de 2012

Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

artículo científico publicado en 2013

Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

artículo científico publicado en 2009

IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform

artículo científico publicado en 2014

Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes ⬇️

artículo científico publicado el 6 de marzo de 2013

Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone

artículo científico publicado en 2006

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

artículo científico publicado en 2015

Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response

artículo científico publicado en 2017

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody ⬇️

artículo científico publicado el 20 de junio de 2011

Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

artículo científico publicado en 2017

PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.

artículo científico publicado en 2012

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

artículo científico publicado en 2014

Profiling human antibody responses by integrated single-cell analysis

artículo científico publicado en 2014

Protection against High-Dose Highly Pathogenic Mucosal SIV Challenge at Very Low Serum Neutralizing Titers of the Antibody-Like Molecule CD4-IgG2 ⬇️

artículo científico publicado el 27 de julio de 2012

Rapid development of glycan-specific, broad, and potent anti–HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque ⬇️

artículo científico publicado el 28 de noviembre de 2011

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

artículo científico publicado en 2011

Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles

artículo científico publicado en 2017

Stimulation of the primary anti-HIV antibody response by IFN-alpha in patients with acute HIV-1 infection

artículo científico publicado en 2008

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

artículo científico publicado en 2014

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

artículo científico publicado en 2010

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

artículo científico publicado en 2013

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

artículo científico publicado en 2013

Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding

artículo científico publicado en 2014

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope

artículo científico publicado en 2014

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

artículo científico publicado en 2015

Lista de obras de

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1.

A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV.

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

Anti-HIV B Cell lines as candidate vaccine biosensors

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses ⬇️

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

CXCL13 is a plasma biomarker of germinal center activity

Cellular immunity elicited by human immunodeficiency virus type 1/ simian immunodeficiency virus DNA vaccination does not augment the sterile protection afforded by passive infusion of neutralizing antibodies

Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.

Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo ⬇️

Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

IDEPI: rapid prediction of HIV-1 antibody epitopes and other phenotypic features from sequence data using a flexible machine learning platform

Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes ⬇️

Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody ⬇️

Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

Profiling human antibody responses by integrated single-cell analysis

Protection against High-Dose Highly Pathogenic Mucosal SIV Challenge at Very Low Serum Neutralizing Titers of the Antibody-Like Molecule CD4-IgG2 ⬇️

Rapid development of glycan-specific, broad, and potent anti–HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque ⬇️

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Single-Virus Droplet Microfluidics for High-Throughput Screening of Neutralizing Epitopes on HIV Particles

Stimulation of the primary anti-HIV antibody response by IFN-alpha in patients with acute HIV-1 infection

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding

Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1