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Animal models of M. tuberculosis Infection

artículo científico publicado en 2007

Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1

scientific article published on 18 June 2018

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice

artículo científico publicado en 2018

Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

scientific article published on 07 October 2013

Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data.

artículo científico publicado en 2007

Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599

scientific article published on 18 July 2019

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.

artículo científico publicado en 2010

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

scientific article published on 28 March 2019

Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection

article

Dynamics of macrophage cell populations during murine pulmonary tuberculosis

artículo científico publicado en 2003

Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis

artículo científico publicado en 2006

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

artículo científico publicado en 2018

Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.

artículo científico publicado en 2015

Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.

artículo científico publicado en 2005

Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family

artículo científico publicado en 2005

GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus.

artículo científico publicado en 2013

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

artículo científico publicado en 2011

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

artículo científico publicado en 2018

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

artículo científico publicado en 2008

In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.

artículo científico publicado en 2002

Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola

scientific article published in PLoS ONE

Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis

artículo científico publicado en 2005

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice

artículo científico publicado en 2008

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis

artículo científico publicado en 2008

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.

artículo científico publicado en 2009

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

artículo científico publicado en 2010

Long-term survival and virulence of Mycobacterium leprae in amoebal cysts

artículo científico publicado en 2014

Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice

artículo científico publicado en 2014

Minipigs as a neonatal animal model for tuberculosis vaccine efficacy testing

scientific article published on 26 July 2019

Modulation of splenic macrophages, and swine leukocyte antigen (SLA) and viral antigen expression following African swine fever virus (ASFV) inoculation

artículo científico publicado el 1 de enero de 1992

Mycobacterium bovis hosted by free-living-amoebae permits their long-term persistence survival outside of host mammalian cells and remain capable of transmitting disease to mice.

artículo científico publicado en 2017

Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models

artículo científico publicado en 2020

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

scientific article published on 20 September 2018

Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells ⬇️

artículo científico publicado el 1 de enero de 2011

Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ

scientific journal article

Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models

scientific article published on 01 March 2009

Polar lipids of Burkholderia pseudomallei induce different host immune responses

artículo científico publicado en 2013

Porcine lymphocyte gamma interferon responses to mitogenic stimuli monitored by a direct immunoassay

artículo científico publicado en 1994

Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis

artículo científico publicado en 2016

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

artículo científico publicado en 2015

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular

article

Reduced in vitro immune response on titania nanotube arrays compared to titanium surface

artículo científico publicado en 2012

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis

artículo científico publicado en 2008

Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis.

artículo científico publicado en 2004

Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies

scientific article published on 06 June 2019

Swine leukocyte antigen and macrophage marker expression on both African swine fever virus-infected and non-infected primary porcine macrophage cultures ⬇️

artículo científico publicado el 1 de mayo de 1992

Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.

artículo científico publicado en 2001

The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.

artículo científico publicado en 2017

The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4

scientific article published on 01 March 2001

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

artículo científico publicado en 2016

Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.

artículo científico publicado en 2005

XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-γ by CD4 T cells and participates in granuloma stability

scientific article published on 15 August 2007

Yersinia pestis Survival and Replication in Potential Ameba Reservoir.

artículo científico publicado en 2018

Lista de obras de

Animal models of M. tuberculosis Infection

Cell mediated immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence strain Rev. 1

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice

Correlates of immune protection following cutaneous immunization with an attenuated Burkholderia pseudomallei vaccine.

Cross-reaction of anti-human CD monoclonal antibodies on guinea pig cells: a summary of the guinea pig section of the HLDA8 animal homologues data.

Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599

Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation.

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection

Dynamics of macrophage cell populations during murine pulmonary tuberculosis

Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis

Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos.

Extended culture of macrophages from different sources and maturation results in a common M2 phenotype.

Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.

Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family

GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus.

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

Immune response to Mycobacterium tuberculosis and identification of molecular markers of disease.

In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.

Interactions of free-living amoebae with rice bacterial pathogens Xanthomonas oryzae pathovars oryzae and oryzicola

Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis

Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection.

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

Long-term survival and virulence of Mycobacterium leprae in amoebal cysts

Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice

Minipigs as a neonatal animal model for tuberculosis vaccine efficacy testing

Modulation of splenic macrophages, and swine leukocyte antigen (SLA) and viral antigen expression following African swine fever virus (ASFV) inoculation

Mycobacterium bovis hosted by free-living-amoebae permits their long-term persistence survival outside of host mammalian cells and remain capable of transmitting disease to mice.

Neonatal and infant immunity for tuberculosis vaccine development: importance of age-matched animal models

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells ⬇️

Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ

Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models

Polar lipids of Burkholderia pseudomallei induce different host immune responses

Porcine lymphocyte gamma interferon responses to mitogenic stimuli monitored by a direct immunoassay

Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis.

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular

Reduced in vitro immune response on titania nanotube arrays compared to titanium surface

Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis

Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis.

Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies

Swine leukocyte antigen and macrophage marker expression on both African swine fever virus-infected and non-infected primary porcine macrophage cultures ⬇️

Temporal and spatial arrangement of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis.

The minipig as an animal model to study Mycobacterium tuberculosis infection and natural transmission.

The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4

Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3

Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages.

XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-γ by CD4 T cells and participates in granuloma stability

Yersinia pestis Survival and Replication in Potential Ameba Reservoir.