Lista de obras -

5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia

artículo científico publicado en 2014

AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor

artículo científico publicado en 2002

Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.

artículo científico publicado en 2004

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

artículo científico publicado en 2012

BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.

artículo científico publicado en 2006

BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity

artículo científico publicado en 2000

BCR: a new target in resistance mediated by BCR/ABL-315I?

artículo científico publicado en 2016

Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein ⬇️

artículo científico publicado el 1 de octubre de 1998

Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells

artículo científico publicado en 1997

Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia

artículo científico publicado en 2005

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

artículo científico publicado en 2012

Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia

scientific article published on 01 January 2001

Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization.

artículo científico publicado en 1995

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia.

artículo científico publicado en 2013

Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.

artículo científico publicado en 2001

Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential.

artículo científico publicado en 2017

Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.

artículo científico publicado en 2002

Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.

artículo científico publicado en 2002

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

artículo científico publicado en 1998

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

artículo científico publicado en 2004

INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity.

artículo científico publicado en 2006

Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.

artículo científico publicado en 2003

Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity.

artículo científico publicado en 2011

Oleylamine-carbonyl-valinol inhibits auto-phosphorylation activity of native and T315I mutated Bcr-Abl, and exhibits selectivity towards oncogenic Bcr-Abl in SupB15 ALL cell lines ⬇️

artículo científico publicado el 5 de diciembre de 2012

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.

artículo científico publicado en 1997

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.

artículo científico publicado en 2012

PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.

artículo científico publicado en 2014

PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

artículo científico publicado en 1999

Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia.

artículo científico publicado en 2004

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study.

artículo científico publicado en 2016

Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.

artículo científico publicado en 2004

Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.

artículo científico publicado en 2006

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.

artículo científico publicado en 2009

STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML

artículo científico publicado en 2014

Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.

artículo científico publicado en 2007

Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα

artículo científico publicado en 2011

Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase acti

artículo científico publicado en 2003

Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL.

artículo científico publicado en 2008

The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex.

artículo científico publicado en 2002

The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies ⬇️

artículo científico publicado el 16 de abril de 1998

The aorta-gonad-mesonephros-derived stroma cell line DAS104-4 induces differentiation of leukemic cells.

artículo científico publicado en 2007

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

artículo científico publicado en 2009

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia

artículo científico publicado en 2015

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

artículo científico publicado en 2009

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

artículo científico publicado en 2005

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis

artículo científico publicado en 2019

The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation

scientific article published on 09 September 2010

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

artículo científico

Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.

artículo científico publicado en 2004

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.

artículo científico publicado en 2011

Lista de obras de

5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia

AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor

Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell.

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.

BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity

BCR: a new target in resistance mediated by BCR/ABL-315I?

Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein ⬇️

Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells

Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia

Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization.

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia.

Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.

Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential.

Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.

Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity.

Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.

Oleic acid is the active component in the mushroom Daedalea gibbosa inhibiting Bcr-Abl kinase autophosphorylation activity.

Oleylamine-carbonyl-valinol inhibits auto-phosphorylation activity of native and T315I mutated Bcr-Abl, and exhibits selectivity towards oncogenic Bcr-Abl in SupB15 ALL cell lines ⬇️

Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling.

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism.

PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.

PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

Peroxisome proliferator-activated receptor gamma ligands induce growth inhibition and apoptosis of human B lymphocytic leukemia.

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study.

Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.

Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.

STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML

Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.

Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα

Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase acti

Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL.

The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex.

The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies ⬇️

The aorta-gonad-mesonephros-derived stroma cell line DAS104-4 induces differentiation of leukemic cells.

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

The phosphatase UBASH3B/Sts-1 is a negative regulator of Bcr-Abl kinase activity and leukemogenesis

The t(6;9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.