Lista de obras -

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

artículo científico publicado en 2017

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

artículo científico publicado en 2011

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

artículo científico publicado en 2005

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.

artículo científico publicado en 2005

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

artículo científico publicado en 2010

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors

artículo científico publicado en 1999

Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

artículo científico publicado en 1999

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

scientific article published on 01 November 1997

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

artículo científico publicado en 2003

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

artículo científico publicado en 2003

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

artículo científico publicado en 2010

Development of molecular probes for the human 5-HT(6) receptor.

artículo científico publicado en 2010

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

artículo científico publicado en 2014

First pharmacophoric hypothesis for 5-HT7 antagonism

artículo científico publicado en 2000

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

artículo científico publicado en 2017

New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.

artículo científico publicado en 2003

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

artículo científico publicado en 2011

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

artículo científico publicado en 2013

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

artículo científico publicado en 2009

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

artículo científico publicado en 2014

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

artículo científico publicado en 1996

Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparis

scientific article published on 01 May 1997

Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.

artículo científico publicado en 1999

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.

artículo científico publicado en 2014

Lista de obras de

A new serotonin 5-HT6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding.

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines.

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.

Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors

Benzimidazole derivatives. Part 1: Synthesis and structure–activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists

Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

Development of Fluorescent Ligands for the Human 5-HT1A Receptor.

Development of molecular probes for the human 5-HT(6) receptor.

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

First pharmacophoric hypothesis for 5-HT7 antagonism

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.

New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.

New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.

Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity

Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparis

Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.

The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.