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A system for concomitant overexpression of four periplasmic folding catalysts to improve secretory protein production in Escherichia coli.

artículo científico publicado en 2006

Enhanced in vivo efficacy of a type I interferon superagonist with extended plasma half-life in a mouse model of multiple sclerosis

artículo científico publicado en 2014

Functional humanization of an anti-CD16 Fab fragment: obstacles of switching from murine {lambda} to human {lambda} or {kappa} light chains.

artículo científico publicado en 2008

Functional humanization of an anti-CD30 Fab fragment for the immunotherapy of Hodgkin's lymphoma using an in vitro evolution approach.

artículo científico publicado en 2004

Fusion of a recombinant antibody fragment with a homo-amino-acid polymer: effects on biophysical properties and prolonged plasma half-life

artículo científico publicado en 2007

High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation

artículo científico publicado en 2015

High molecular mass radioimmunoconjugates are promising for intraperitoneal α-emitter immunotherapy due to prolonged retention in the peritoneum

artículo científico publicado en 2012

Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats

article

Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lep(ob/ob) Mice

artículo científico

Novel serial positive enrichment technology enables clinical multiparameter cell sorting

artículo científico publicado en 2012

PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro

artículo científico publicado en 2016

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

artículo científico publicado en 2013

Periplasmic chaperones used to enhance functional secretion of proteins in E. coli

artículo científico publicado en 2011

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity

artículo científico publicado en 2016

The periplasmic E. coli chaperone Skp is a trimer in solution: biophysical and preliminary crystallographic characterization

artículo científico publicado en 2004

Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation

artículo científico publicado en 2016

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