Lista de obras -

A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.

artículo científico publicado en 2005

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

artículo científico publicado en 2004

Adhesion articulated

scientific article published in Nature

Analyzing integrin-dependent adhesion.

artículo científico publicado en 2002

Analyzing integrin-dependent adhesion.

artículo científico publicado en 2011

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

artículo científico publicado en 2003

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

artículo científico publicado en 1997

Demonstration of catch bonds between an integrin and its ligand.

artículo científico publicado en 2009

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

artículo científico publicado en 2014

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

artículo científico publicado en 2008

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

artículo científico publicado en 2005

E-cadherin is a ligand for integrin α2β1

article

Evidence for the presence of a low-mass beta1 integrin on the cell surface.

artículo científico publicado en 2005

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

artículo científico publicado en 2004

Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.

artículo científico publicado en 1994

Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4

artículo científico publicado en 2018

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

artículo científico publicado en 1999

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

artículo científico publicado en 2000

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

artículo científico publicado en 1995

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin ⬇️

artículo científico publicado el 1 de diciembre de 1991

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)

artículo científico publicado en 2006

Integrin αvβ1 Is a Receptor for Foot-and-Mouth Disease Virus ⬇️

artículo científico publicado el 1 de febrero de 2002

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

artículo científico publicado en 2016

Mapping functional residues onto integrin crystal structures.

artículo científico publicado en 2003

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

artículo científico publicado en 2009

Molecular Basis of Ligand Recognition by Integrin α5β1

scientific article published in Journal of Biological Chemistry

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

artículo científico publicado en 2004

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

artículo científico publicado en 2004

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

artículo científico publicado en 2003

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

artículo científico publicado en 2015

Solid phase assays for studying ECM protein-protein interactions

artículo científico publicado en 2009

Solid phase assays for studying ECM protein-protein interactions.

artículo científico publicado en 2000

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

artículo científico publicado en 2016

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

artículo científico publicado en 2017

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

artículo científico publicado en 2003

The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.

artículo científico publicado en 2006

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

artículo científico publicado en 1996

The collagens of hydra provide insight into the evolution of metazoan extracellular matrices.

artículo científico publicado en 2007

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

artículo científico publicado en 2017

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.

artículo científico publicado en 2005

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

artículo científico publicado en 2017

Lista de obras de

A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Adhesion articulated

Analyzing integrin-dependent adhesion.

Analyzing integrin-dependent adhesion.

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

Demonstration of catch bonds between an integrin and its ligand.

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.

Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

E-cadherin is a ligand for integrin α2β1

Evidence for the presence of a low-mass beta1 integrin on the cell surface.

Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.

Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.

Extracellular Histones Inhibit Complement Activation through Interacting with Complement Component 4

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin ⬇️

Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)

Integrin αvβ1 Is a Receptor for Foot-and-Mouth Disease Virus ⬇️

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

Mapping functional residues onto integrin crystal structures.

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

Molecular Basis of Ligand Recognition by Integrin α5β1

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

Solid phase assays for studying ECM protein-protein interactions

Solid phase assays for studying ECM protein-protein interactions.

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP.

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

The collagens of hydra provide insight into the evolution of metazoan extracellular matrices.

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function