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2,2'-Dihydroxybenzophenones and their carbonyl N-analogues as inhibitor scaffolds for MDR-involved human glutathione transferase isoenzyme A1-1.

artículo científico publicado en 2014

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF

scientific article published on 07 November 2011

A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.

artículo científico publicado en 1998

A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice

artículo científico publicado en 2014

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).

artículo científico publicado en 2017

Current Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

artículo científico publicado en 2018

Designer xanthone: an inhibitor scaffold for MDR-involved human glutathione transferase isoenzyme A1-1.

artículo científico publicado en 2013

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.

artículo científico publicado en 1996

Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.

artículo científico publicado en 2003

FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents: a report of the Federation of European Laboratory Animal Science Associations Working Group

artículo científico publicado en 2013

In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

scientific article published on 25 July 2018

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

artículo científico publicado en 1997

Irisin: good or bad for the bone? A new path forward after the reported discovery of irisin receptor?

scientific article published on 25 January 2019

MUGEN mouse database; animal models of human immunological diseases

artículo científico publicado en 2008

Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice

artículo científico publicado en 2019

New Insights for RANKL as a Proinflammatory Modulator in Modeled Inflammatory Arthritis

scientific article published on 05 February 2019

Novel genetic models of osteoporosis by overexpression of human RANKL in transgenic mice

artículo científico publicado en 2014

Novel insights into SLC25A46-related pathologies in a genetic mouse model

artículo científico publicado en 2017

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

artículo científico publicado en 2019

Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects

artículo científico publicado en 2014

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice.

artículo científico publicado en 2015

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study

artículo científico publicado en 2012

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

scientific journal article

The unbearable lightness of bone marrow homeostasis.

artículo científico publicado en 2014

Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution

scientific article published on 18 May 2018

Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo

artículo científico publicado en 2002

Tumour necrosis factors in immune regulation: everything that's interesting is...new!

artículo científico publicado en 1996