Lista de obras -

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase

artículo científico publicado en 1997

A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: functional characterisation and signatures of selection.

artículo científico publicado en 2012

A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces

artículo científico publicado en 2008

A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.

artículo científico publicado en 2010

A simple glutathione transferase-based colorimetric endpoint assay for insecticide detection

scholarly article by Andrew J. Dowd et al published August 2009 in Enzyme and Microbial Technology

Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae.

artículo científico publicado en 2014

Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.

artículo científico publicado en 2006

Antimalarial activity of primaquine operates via a two-step biochemical relay

scientific article published on 19 July 2019

Axonal loss and myelin in early ON loss in postacute optic neuritis.

artículo científico publicado en 2008

Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits

artículo científico publicado en 2011

Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.

artículo científico publicado en 2006

CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae

artículo científico publicado en 2014

Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction.

artículo científico publicado en 2018

Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.

artículo científico publicado en 2008

Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis

artículo científico publicado en 2014

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution

artículo científico publicado en 1999

Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase

scientific article published on 01 March 1996

Development of a colourimetric pH assay for the quantification of pyrethroids based on glutathione-S-transferase

article

Differential Ability of Cytostatics From Anthraquinone Group to Generate Free Radicals in Three Enzymatic Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase ⬇️

artículo científico publicado el 1 de enero de 2003

Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.

artículo científico publicado en 2012

Engineering of a functional human NADH-dependent cytochrome P450 system

artículo científico publicado en 2001

Engineering sensitive glutathione transferase for the detection of xenobiotics.

artículo científico publicado en 2008

Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu

artículo científico publicado en 2014

Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids

artículo científico publicado en 2008

Functional characterisation of cytochrome P450s involved in insecticide resistance in major malaria vector Anopheles funestus across Africa

artículo científico publicado en 2014

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

artículo científico publicado en 1996

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

artículo científico publicado en 2006

Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana

artículo científico publicado en 2012

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

artículo científico publicado en 2006

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

artículo científico publicado en 2007

Interrelationship of optical coherence tomography and multifocal visual-evoked potentials after optic neuritis.

artículo científico publicado en 2009

Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae

artículo científico publicado en 2014

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

artículo científico publicado en 1997

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

artículo científico publicado en 2008

Persistence on therapy and propensity matched outcome comparison of two subcutaneous interferon beta 1a dosages for multiple sclerosis

artículo científico publicado en 2013

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

artículo científico publicado en 2004

Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae.

artículo científico publicado en 2016

Rainbow tags: a visual tag system for recombinant protein expression and purification.

artículo científico publicado en 2005

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

artículo científico publicado en 2002

Remyelination of optic nerve lesions: spatial and temporal factors

artículo científico publicado en 2010

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

artículo científico publicado en 2021

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

artículo científico publicado en 2002

Risk of relapse phenotype recurrence in multiple sclerosis.

artículo científico publicado en 2014

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

artículo científico publicado en 2003

Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

artículo científico publicado en 2013

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant

artículo científico publicado en 2012

Seasonal variation of relapse rate in multiple sclerosis is latitude dependent.

artículo científico publicado en 2014

Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae).

artículo científico publicado en 2010

Stage specific differences in steady state levels of mRNA encoding the major surface glycoprotein of Brugia pahangi.

artículo científico publicado en 1994

Structural studies on FMN domain of cytochrome P450 reductase

artículo científico publicado en 1995

The molecular cloning of a phospholipase A2 from Bothrops jararacussu snake venom: Evolution of venom group II phospholipase A2's may imply gene duplications ⬇️

artículo científico publicado el 1 de agosto de 1995

The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.

artículo científico publicado en 2005

Trp-676 Facilitates Nicotinamide Coenzyme Exchange in the Reductive Half-Reaction of Human Cytochrome P450 Reductase: Properties of the Soluble W676H and W676A Mutant Reductases†

article

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

article

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

artículo científico publicado en 2005

Lista de obras de

1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase

A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: functional characterisation and signatures of selection.

A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces

A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.

A simple glutathione transferase-based colorimetric endpoint assay for insecticide detection

Abamectin is metabolized by CYP392A16, a cytochrome P450 associated with high levels of acaricide resistance in Tetranychus urticae.

Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.

Antimalarial activity of primaquine operates via a two-step biochemical relay

Axonal loss and myelin in early ON loss in postacute optic neuritis.

Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traits

Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.

CYP6 P450 enzymes and ACE-1 duplication produce extreme and multiple insecticide resistance in the malaria mosquito Anopheles gambiae

Characterisation of Anopheles gambiae heme oxygenase and metalloporphyrin feeding suggests a potential role in reproduction.

Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.

Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis

Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution

Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase

Development of a colourimetric pH assay for the quantification of pyrethroids based on glutathione-S-transferase

Differential Ability of Cytostatics From Anthraquinone Group to Generate Free Radicals in Three Enzymatic Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase ⬇️

Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus.

Engineering of a functional human NADH-dependent cytochrome P450 system

Engineering sensitive glutathione transferase for the detection of xenobiotics.

Evaluating the feasibility of using insecticide quantification kits (IQK) for estimating cyanopyrethroid levels for indoor residual spraying in Vanuatu

Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids

Functional characterisation of cytochrome P450s involved in insecticide resistance in major malaria vector Anopheles funestus across Africa

Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana

In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

Interrelationship of optical coherence tomography and multifocal visual-evoked potentials after optic neuritis.

Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.

Persistence on therapy and propensity matched outcome comparison of two subcutaneous interferon beta 1a dosages for multiple sclerosis

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae.

Rainbow tags: a visual tag system for recombinant protein expression and purification.

Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.

Remyelination of optic nerve lesions: spatial and temporal factors

Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Risk of relapse phenotype recurrence in multiple sclerosis.

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant

Seasonal variation of relapse rate in multiple sclerosis is latitude dependent.

Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae).

Stage specific differences in steady state levels of mRNA encoding the major surface glycoprotein of Brugia pahangi.

Structural studies on FMN domain of cytochrome P450 reductase

The molecular cloning of a phospholipase A2 from Bothrops jararacussu snake venom: Evolution of venom group II phospholipase A2's may imply gene duplications ⬇️

The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.

Trp-676 Facilitates Nicotinamide Coenzyme Exchange in the Reductive Half-Reaction of Human Cytochrome P450 Reductase: Properties of the Soluble W676H and W676A Mutant Reductases†

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.