Lista de obras -

A 2015 focus on preventing drug-induced arrhythmias.

artículo científico publicado en 2015

A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.

artículo científico publicado en 2016

A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology.

artículo científico publicado en 2016

A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

artículo científico publicado en 2012

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.

artículo científico publicado en 2014

AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.

artículo científico publicado en 2014

Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model.

artículo científico publicado en 2010

Barium toxicity and the role of the potassium inward rectifier current

artículo científico publicado en 2014

Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.

artículo científico publicado en 2016

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.

artículo científico

Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes

artículo científico publicado en 2007

Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent

artículo científico publicado en 2016

Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling.

artículo científico publicado en 2009

Cardiac ion channel trafficking defects and drugs.

artículo científico publicado en 2013

Cardiomyocytes from human and mouse embryonic stem cells.

artículo científico publicado en 2007

Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking

artículo científico publicado en 2017

Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis.

artículo científico publicado en 2005

Cloning, sequence analysis and phylogeny of connexin43 isolated from American black bear heart

artículo científico publicado en 2007

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

artículo científico publicado en 2012

Connexin43 expression during Xenopus development.

artículo científico publicado en 2001

Connexin43 orthologues in vertebrates: phylogeny from fish to man.

artículo científico publicado en 2004

Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.

artículo científico publicado en 2007

Deciphering hERG channels: Molecular basis of the rapid component of the delayed rectifier potassium current ⬇️

artículo científico publicado el 26 de junio de 2012

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking

artículo científico publicado en 2019

Dominant missense mutations in ABCC9 cause Cantú syndrome.

artículo científico publicado en 2012

Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity

scientific article published on 27 May 2011

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

artículo científico publicado en 2007

Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation

artículo científico publicado en 2018

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor.

artículo científico publicado en 1997

Epigenetics: DNA demethylation promotes skeletal myotube maturation.

artículo científico publicado en 2011

Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine KIR2.2 ion Channel ⬇️

artículo científico publicado el 30 de enero de 2012

Expression of the electrophysiological system during murine embryonic stem cell cardiac differentiation.

artículo científico publicado en 2003

Finding Inward Rectifier Channel Inhibitors: Why and How? ⬇️

artículo científico publicado el 9 de enero de 2012

Foetal and adult cardiomyocyte progenitor cells have different developmental potential

artículo científico publicado en 2010

Fraud and misconduct in science: the stem cell seduction: Implications for the peer-review process.

artículo científico publicado en 2009

Geographical distribution of plakophilin-2 mutation prevalence in patients with arrhythmogenic cardiomyopathy ⬇️

artículo científico publicado el 1 de mayo de 2012

Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents

artículo científico publicado en 2019

Grayanotoxin poisoning: 'mad honey disease' and beyond

artículo científico publicado en 2012

High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block

artículo científico publicado en 2010

Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype.

artículo científico publicado en 2009

Identification of an intracellular domain of the EGF receptor required for high-affinity binding of EGF.

artículo científico publicado en 1997

Impact Factor of the Chinese Journal of Physiology in 2009: Meet the Readers

artículo científico publicado el 31 de agosto de 2010

Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.

artículo científico publicado en 2012

Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

artículo científico publicado en 2013

Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.

artículo científico publicado en 2006

Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

artículo científico publicado en 2014

LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1.

scientific article published on 02 April 2020

LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

scientific article published on 30 August 2019

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.

artículo científico publicado en 2008

Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.

artículo científico publicado en 1996

Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels

scientific article published on 22 July 2011

Mesenchymal stem cells repair conduction block

artículo científico publicado en 2006

Molecular aspects of adrenergic modulation of cardiac L-type Ca2+ channels.

artículo científico publicado en 2005

Molecular aspects of adrenergic modulation of the transient outward current.

artículo científico publicado en 2006

P19 embryonal carcinoma cells: a suitable model system for cardiac electrophysiological differentiation at the molecular and functional level.

artículo científico publicado en 2003

Personalized medicine and the role of induced pluripotent stem cells ⬇️

artículo científico publicado el 20 de julio de 2012

Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation

artículo científico publicado en 2015

Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

artículo científico publicado en 2013

Regulated expression of the X. tropicalis connexin43 promoter.

artículo científico publicado en 2001

Regulatory roles of the ubiquitin-proteasome system in cardiomyocyte apoptosis.

artículo científico publicado en 2010

Review of case reports on hyperkalemia induced by dietary intake: not restricted to chronic kidney disease patients

artículo científico publicado en 2018

Rewiring the heart: stem cell therapy to restore normal cardiac excitability and conduction.

scientific article published on January 2009

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.

artículo científico publicado en 2010

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

artículo científico publicado en 2018

Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

artículo científico publicado en 2008

Sex hormones and jumping heart beats

artículo científico publicado en 2019

Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison with QT variability index

artículo científico publicado en 2011

Spotlight on stem cells--makes old hearts fresh

scientific article published on 01 May 2003

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

artículo científico publicado en 2015

The actin binding domain of the epidermal growth factor receptor is required for EGF-stimulated tissue invasion.

artículo científico publicado en 1997

The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

artículo científico publicado en 2010

The hidden secrets of the hibernator's heart may protect against arrhythmias

artículo científico publicado en 2005

The secrets of hibernators' cardiac conduction reserve

scientific article published on 06 September 2008

Toward specific cardiac I(K1) modulators for in vivo application: old drugs point the way.

scientific article published on 02 February 2011

Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease

artículo científico publicado en 2020

Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human? ⬇️

artículo científico publicado el 1 de mayo de 2012

Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model

artículo científico publicado en 2013

Lista de obras de

A 2015 focus on preventing drug-induced arrhythmias.

A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.

A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology.

A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane.

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.

AV-block and conduction slowing prevail over TdP arrhythmias in the methoxamine-sensitized pro-arrhythmic rabbit model.

Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model.

Barium toxicity and the role of the potassium inward rectifier current

Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo.

Beta-, not alpha-adrenergic stimulation enhances conduction velocity in cultures of neonatal cardiomyocytes

Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent

Cardiac cell-cell junctions in health and disease: Electrical versus mechanical coupling.

Cardiac ion channel trafficking defects and drugs.

Cardiomyocytes from human and mouse embryonic stem cells.

Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking

Cloning and functional characterization of a novel connexin expressed in somites of Xenopus laevis.

Cloning, sequence analysis and phylogeny of connexin43 isolated from American black bear heart

Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

Connexin43 expression during Xenopus development.

Connexin43 orthologues in vertebrates: phylogeny from fish to man.

Connexin43 repression following epithelium-to-mesenchyme transition in embryonal carcinoma cells requires Snail1 transcription factor.

Deciphering hERG channels: Molecular basis of the rapid component of the delayed rectifier potassium current ⬇️

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking

Dominant missense mutations in ABCC9 cause Cantú syndrome.

Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

Efficacy of pentamidine analogue 6 in dogs with chronic atrial fibrillation

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor.

Epigenetics: DNA demethylation promotes skeletal myotube maturation.

Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine KIR2.2 ion Channel ⬇️

Expression of the electrophysiological system during murine embryonic stem cell cardiac differentiation.

Finding Inward Rectifier Channel Inhibitors: Why and How? ⬇️

Foetal and adult cardiomyocyte progenitor cells have different developmental potential

Fraud and misconduct in science: the stem cell seduction: Implications for the peer-review process.

Geographical distribution of plakophilin-2 mutation prevalence in patients with arrhythmogenic cardiomyopathy ⬇️

Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents

Grayanotoxin poisoning: 'mad honey disease' and beyond

High-rate pacing reduces variability of repolarization and prevents repolarization-dependent arrhythmias in dogs with chronic AV block

Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype.

Identification of an intracellular domain of the EGF receptor required for high-affinity binding of EGF.

Impact Factor of the Chinese Journal of Physiology in 2009: Meet the Readers

Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.

Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs.

Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.

Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

LUF7244 plus dofetilide rescues aberrant Kv11.1 trafficking and produces functional IKv11.1.

LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density.

Maximal epidermal growth-factor-induced cytosolic phospholipase A2 activation in vivo requires phosphorylation followed by an increased intracellular calcium concentration.

Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels

Mesenchymal stem cells repair conduction block

Molecular aspects of adrenergic modulation of cardiac L-type Ca2+ channels.

Molecular aspects of adrenergic modulation of the transient outward current.

P19 embryonal carcinoma cells: a suitable model system for cardiac electrophysiological differentiation at the molecular and functional level.

Personalized medicine and the role of induced pluripotent stem cells ⬇️

Pharmacological exploration of the resting membrane potential reserve: Impact on atrial fibrillation

Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

Regulated expression of the X. tropicalis connexin43 promoter.

Regulatory roles of the ubiquitin-proteasome system in cardiomyocyte apoptosis.

Review of case reports on hyperkalemia induced by dietary intake: not restricted to chronic kidney disease patients

Rewiring the heart: stem cell therapy to restore normal cardiac excitability and conduction.

Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.

Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins.

Sex hormones and jumping heart beats

Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison with QT variability index

Spotlight on stem cells--makes old hearts fresh

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

The actin binding domain of the epidermal growth factor receptor is required for EGF-stimulated tissue invasion.

The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

The hidden secrets of the hibernator's heart may protect against arrhythmias

The secrets of hibernators' cardiac conduction reserve

Toward specific cardiac I(K1) modulators for in vivo application: old drugs point the way.

Towards the Development of AgoKirs: New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease

Verapamil as an antiarrhythmic agent in congestive heart failure: hopping from rabbit to human? ⬇️

Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model