Lista de obras -

A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

artículo científico publicado en 2022

A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease.

artículo científico publicado en 2014

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

artículo científico publicado en 2014

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

artículo científico publicado en 2010

Beyond the brain: huntingtin in breast cancers

artículo científico publicado en 2016

Cancer: From Wild-Type to Mutant Huntingtin.

artículo científico publicado en 2018

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

artículo científico publicado en 2003

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin

scientific article published on 01 July 2020

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

artículo científico publicado en 2006

Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease

artículo científico publicado en 2006

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

artículo científico publicado en 2010

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

artículo científico publicado en 2016

Elongator – an emerging role in neurological disorders

artículo científico publicado en 2009

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

artículo científico publicado en 2007

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

artículo científico publicado en 2015

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

artículo científico publicado en 2013

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

scientific journal article

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

artículo científico publicado en 2010

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

artículo científico publicado en 2013

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

artículo científico publicado en 2008

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

artículo científico publicado en 2015

Huntingtin regulates mammary stem cell division and differentiation.

artículo científico publicado en 2014

Huntingtin, mitosis and cell fate

artículo científico publicado en 2011

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.

artículo científico publicado en 2016

Huntingtin: here, there, everywhere!

artículo científico publicado en 2013

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

artículo científico publicado en 2006

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

artículo científico publicado en 2004

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

artículo científico publicado en 2013

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

artículo científico publicado en 2003

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

artículo científico publicado en 2006

Is Huntington disease a developmental disorder? ⬇️

artículo científico publicado el 1 de diciembre de 2010

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

artículo científico publicado en 2007

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

artículo científico publicado en 2014

Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex

artículo científico publicado en 2014

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

artículo científico publicado en 2010

Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities ⬇️

artículo científico publicado el 1 de julio de 1995

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

artículo científico publicado en 2005

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

artículo científico publicado en 2007

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

artículo científico publicado en 2008

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

artículo científico publicado en 2021

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

artículo científico publicado en 2016

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

artículo científico publicado en 2014

Synaptic localization of p39, a neuronal activator of cdk5

artículo científico publicado en 2000

The Biology of Huntingtin.

artículo científico publicado en 2016

The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH.

artículo científico publicado en 1994

The biology of Huntington's disease.

artículo científico publicado en 2008

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

artículo científico publicado en 2004

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

artículo científico publicado en 2018

Toward cell specificity in SCA1

artículo científico publicado en 2002

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

artículo científico publicado en 2017

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

scientific journal article

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair

artículo científico publicado en 1994

Lista de obras de

A pathogenic proteolysis-resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function

A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease.

Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts.

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

Beyond the brain: huntingtin in breast cancers

Cancer: From Wild-Type to Mutant Huntingtin.

Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease

Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

Cysteamine restores intracellular dynamics and BDNF secretion in Huntington's disease

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Elongator – an emerging role in neurological disorders

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouse

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

Huntingtin regulates mammary stem cell division and differentiation.

Huntingtin, mitosis and cell fate

Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.

Huntingtin: here, there, everywhere!

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

Huntington's disease: how does huntingtin, an anti-apoptotic protein, become toxic?

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice.

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Is Huntington disease a developmental disorder? ⬇️

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex

Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease

Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities ⬇️

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.

Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment

Serine 421 regulates mutant huntingtin toxicity and clearance in mice.

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

Synaptic localization of p39, a neuronal activator of cdk5

The Biology of Huntingtin.

The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH.

The biology of Huntington's disease.

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

Toward cell specificity in SCA1

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment

p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair