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A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model

artículo científico publicado en 2017

A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination

artículo científico publicado en 2002

A new primate model for multiple sclerosis in the common marmoset

scientific article published on 01 June 2000

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice

artículo científico publicado en 1999

Acute cerebral white matter damage in lethal salicylate intoxication

artículo científico publicado en 2007

After injection into the striatum, in vitro-differentiated microglia- and bone marrow-derived dendritic cells can leave the central nervous system via the blood stream.

artículo científico publicado en 2008

Antibodies against human BLyS and APRIL attenuate EAE development in marmoset monkeys.

artículo científico publicado en 2012

Apoptosis-inducing factor in nigral dopamine neurons: Higher levels in primates than in mice

artículo científico publicado en 2016

Astrocyte-derived tissue Transglutaminase affects fibronectin deposition, but not aggregation, during cuprizone-induced demyelination

artículo científico publicado en 2017

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

artículo científico publicado en 2014

Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis ?

artículo científico publicado en 2015

Autoimmune epilepsies

artículo científico publicado en 2014

Autoimmunity against myelin oligodendrocyte glycoprotein is dispensable for the initiation although essential for the progression of chronic encephalomyelitis in common marmosets

artículo científico publicado en 2008

B-cell depletion abrogates T cell-mediated demyelination in an antibody-nondependent common marmoset experimental autoimmune encephalomyelitis model.

artículo científico publicado en 2012

B-cell depletion attenuates white and gray matter pathology in marmoset experimental autoimmune encephalomyelitis.

artículo científico publicado en 2011

Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis.

artículo científico publicado en 2015

CCR5 blockade for neuroinflammatory diseases--beyond control of HIV.

artículo científico publicado en 2016

CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model

artículo científico publicado en 2016

CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A*0201-transgenic mice.

artículo científico

CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice.

artículo científico publicado en 2016

CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

scientific article published on 18 December 2019

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model.

artículo científico publicado en 2016

Cell type-specific Nrf2 expression in multiple sclerosis lesions.

artículo científico publicado en 2015

Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice

artículo científico publicado en 2011

Complement-associated neuronal loss in a patient with CASPR2 antibody-associated encephalitis

artículo científico publicado en 2015

Cortical demyelination can be modeled in specific rat models of autoimmune encephalomyelitis and is major histocompatibility complex (MHC) haplotype-related.

artículo científico publicado en 2006

Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes.

artículo científico

Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases.

artículo científico publicado en 2002

Demonstration of interleukin-1 beta in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

scientific article published on 01 October 1993

Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis.

artículo científico publicado en 2016

Discrepant effects of human interferon-gamma on clinical and immunological disease parameters in a novel marmoset model for multiple sclerosis.

artículo científico publicado en 2011

Disease-specific molecular events in cortical multiple sclerosis lesions.

artículo científico publicado en 2013

Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis.

artículo científico publicado en 2006

Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat.

artículo científico publicado en 1998

Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes.

artículo científico publicado en 2003

Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: A light and electron microscopic study

artículo científico publicado el 1 de abril de 1995

Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice.

artículo científico publicado en 2003

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

artículo científico publicado en 2016

Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells

artículo científico publicado en 2008

Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.

artículo científico publicado en 2004

Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy.

artículo científico publicado en 2013

IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration

artículo científico publicado en 2019

IgG and complement deposition and neuronal loss in cats and humans with epilepsy and voltage-gated potassium channel complex antibodies

artículo científico publicado en 2014

Immune profile of an atypical EAE model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund's adjuvant

artículo científico publicado en 2015

Immune-complex-trapping cells in the spleen of the oriental fire-bellied toad, Bombina orientalis.

artículo científico publicado en 1993

In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS.

artículo científico

Induction of Experimental Autoimmune Encephalomyelitis With Recombinant Human Myelin Oligodendrocyte Glycoprotein in Incomplete Freund’s Adjuvant in Three Non-human Primate Species

artículo científico publicado el 3 de julio de 2013

Inflammation induced by innate immunity in the central nervous system leads to primary astrocyte dysfunction followed by demyelination.

artículo científico publicado en 2010

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.

artículo científico publicado en 2010

Innate and adaptive immunity in human epilepsies

artículo científico publicado en 2017

Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis

artículo científico publicado en 2007

Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats

artículo científico publicado en 2013

Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection

artículo científico publicado en 2014

Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?

artículo científico publicado en 2007

Microglial nodules provide the environment for pathogenic T cells in human encephalitis

artículo científico publicado en 2019

NG2 plays a role in neuroinflammation but is not expressed by immune cells.

artículo científico publicado en 2017

Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo.

artículo científico publicado en 2009

Neuropathological Techniques to Investigate Central Nervous System Sections in Multiple Sclerosis

artículo científico publicado en 2016

Neuropathology of autoimmune encephalitides.

artículo científico publicado en 2016

Neuroprotection requires the functions of the RNA-binding protein HuR.

artículo científico publicado en 2014

Non-human primate models of experimental autoimmune encephalomyelitis: Variations on a theme.

artículo científico publicado en 2005

Non-invasive measurement of brain damage in a primate model of multiple sclerosis.

artículo científico publicado en 2004

Non‐human primate models of multiple sclerosis

artículo científico publicado el 1 de octubre de 2001

Notch1 and its ligand Jagged1 are present in remyelination in a T-cell- and antibody-mediated model of inflammatory demyelination.

artículo científico publicado en 2006

Novel Insights into the Distribution and Functional Aspects of the Calcium Binding Protein Secretagogin from Studies on Rat Brain and Primary Neuronal Cell Culture

artículo científico publicado el 6 de agosto de 2012

Oligodendrocyte-specific protein is encephalitogenic in rhesus macaques and induces specific demyelination of the optic nerve

scientific article published on 01 May 2008

Overview of models, methods, and reagents developed for translational autoimmunity research in the common marmoset (Callithrix jacchus).

artículo científico publicado en 2013

Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis.

artículo científico publicado en 2017

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.

artículo científico publicado en 2014

Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series

scientific article published on 01 April 2019

Pathophysiology of antibody-associated diseases of the central nervous system

artículo científico publicado en 2013

Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin

artículo científico publicado en 2010

Pertussis toxin reduces the number of splenic Foxp3+ regulatory T cells.

artículo científico

Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum.

artículo científico publicado en 2010

Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome (IRIS).

artículo científico

Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition

artículo científico publicado en 2014

Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis.

artículo científico publicado en 2007

Rasmussen's encephalitis: a role for autoimmune cytotoxic T lymphocytes.

artículo científico publicado en 2002

Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances.

artículo científico publicado en 2014

Re-expression of N-cadherin in remyelinating lesions of experimental inflammatory demyelination

artículo científico publicado en 2012

Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats

artículo científico publicado en 1995

Resident microglia and hematogenous macrophages as phagocytes in adoptively transferred experimental autoimmune transferred experimental autoimmune encephalomyelitis: An investigation using rat radiation bone marrow chimeras

artículo científico publicado en 1995

Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T- and B-cell epitopes

artículo científico publicado en 2000

Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis

artículo científico publicado en 2017

Selective Limbic Blood-Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies.

artículo científico publicado en 2017

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis

artículo científico publicado en 2015

Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey

artículo científico publicado en 2017

Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples.

artículo científico publicado en 2018

T cell-activation in neuromyelitis optica lesions plays a role in their formation.

artículo científico publicado en 2013

Targeted Diet Modification Reduces Multiple Sclerosis-like Disease in Adult Marmoset Monkeys from an Outbred Colony

artículo científico publicado en 2018

Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity

artículo científico publicado en 2009

The Functional Activity of High Endothelial Venules: A Role for the Subcapsular Sinus Macrophages in the Lymph NodeREIN

artículo científico publicado el 1 de junio de 1991

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

artículo científico publicado en 2018

The different clinical effects of anti-BLyS, anti-APRIL and anti-CD20 antibodies point at a critical pathogenic role of γ-herpesvirus infected B cells in the marmoset EAE model.

artículo científico publicado en 2013

The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.

artículo científico publicado en 2006

The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain

scientific journal article

The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset.

artículo científico publicado en 2010

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

article

Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8+ T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome

scientific article published on 15 January 2015

Tissue transglutaminase activity is involved in the differentiation of oligodendrocyte precursor cells into myelin‐forming oligodendrocytes during CNS remyelination

artículo científico publicado el 11 de julio de 2011

Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis.

artículo científico publicado en 1999

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells

artículo científico publicado en 2020

Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases

artículo científico publicado en 2004

Which pathomechanism damages the brain in antibody-associated CNS disease?

artículo científico publicado en 2011

Widespread demyelination in the cerebellar cortex in multiple sclerosis.

artículo científico publicado en 2007