Lista de obras -

-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

scientific article published in Journal of Biological Chemistry

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

artículo científico publicado en 2016

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase

artículo científico publicado en 2014

A new structural insight into XPA-DNA interactions

artículo científico publicado en 2014

Akt activation by human T-cell leukemia virus tax oncoprotein

artículo científico publicado en 2015

Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells

artículo científico publicado en 2017

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies

artículo científico publicado en 2016

Allosteric inhibition of HIV-1 integrase activity

artículo científico publicado en 2013

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

artículo científico publicado en 2013

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

artículo científico publicado en 2014

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

artículo científico publicado en 2009

Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen

artículo científico publicado en 2009

BET proteins promote efficient murine leukemia virus integration at transcription start sites

scientific article published on July 2013

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

scientific article published on 11 February 2014

Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.

artículo científico publicado en 2009

Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses

artículo científico publicado en 2012

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

artículo científico publicado en 2016

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

artículo científico publicado en 2006

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

artículo científico publicado en 2017

Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism

artículo científico publicado en 2016

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

artículo científico publicado en 2008

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75 ⬇️

artículo científico publicado el 19 de julio de 2011

Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs

artículo científico publicado en 2010

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

artículo científico publicado en 2016

HIV-1 Integrase-DNA Recognition Mechanisms

artículo científico publicado en 2009

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

article

HIV-1 integrase multimerization as a therapeutic target

artículo científico

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

artículo científico publicado en 2012

High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA.

artículo científico publicado en 2007

Human T-lymphotropic Virus Type 1 p30 Interacts with REGγ and Modulates ATM (Ataxia Telangiectasia Mutated) to Promote Cell Survival ⬇️

artículo científico publicado el 7 de enero de 2011

Human T-lymphotropic virus type 1 p30 interacts with REGγ and ATM (Ataxia Telangiectasia Mutated) to promote cell survival

Identification and characterization of HTLV-1 HBZ post-translational modifications

artículo científico publicado en 2014

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

artículo científico publicado en 2004

Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry

artículo científico publicado en 2004

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells

artículo científico publicado en 2010

Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent

artículo científico publicado en 2002

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

artículo científico publicado en 2012

Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch

artículo científico publicado en 2006

Interactions of HIV-1 Gag with assembly cofactors

artículo científico publicado en 2006

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

artículo científico publicado en 2016

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

artículo científico publicado en 2015

Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA.

artículo científico publicado en 2005

Mass spectrometry-based footprinting of protein-protein interactions

artículo científico publicado en 2008

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications

artículo científico publicado en 2017

Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase

artículo científico publicado en 2016

Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.

artículo científico publicado en 2005

Molecular mechanisms of retroviral integration site selection

artículo científico publicado en 2014

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

artículo científico publicado en 2012

N6-methyladenosine Binding Proteins Negatively Regulate HIV-1 Infectivity and Viral Production

article

Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase

artículo científico publicado en 2003

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

article

Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase

artículo científico publicado en 2002

Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting

artículo científico publicado en 2009

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing

artículo científico publicado en 2017

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

artículo científico publicado en 2018

Structural Studies and Biological Evaluation of T30695 Variants Modified with Single Chiral Glycerol-T Reveal the Importance of LEDGF/p75 for the Aptamer Anti-HIV-Integrase Activities

article

Structural analysis of protein-RNA interactions with mass spectrometry

artículo científico publicado en 2008

Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina

artículo científico publicado en 2007

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

artículo científico publicado en 2013

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

artículo científico publicado en 2016

Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding

artículo científico publicado en 2007

TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

artículo científico publicado en 2014

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

artículo científico publicado en 2013

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

artículo científico publicado en 2016

The FACT Complex Promotes Avian Leukosis Virus DNA Integration

artículo científico publicado en 2017

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

artículo científico publicado en 2014

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins

artículo científico publicado en 2016

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

artículo científico publicado en 2016

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

artículo científico publicado en 2008

Lista de obras de

-Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase

A new structural insight into XPA-DNA interactions

Akt activation by human T-cell leukemia virus tax oncoprotein

Allosteric HIV-1 Integrase Inhibitors Lead to Premature Degradation of the Viral RNA Genome and Integrase in Target Cells

Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies

Allosteric inhibition of HIV-1 integrase activity

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes

Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.

Comparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75 ⬇️

Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

HIV-1 Integrase-DNA Recognition Mechanisms

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

HIV-1 integrase multimerization as a therapeutic target

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

High resolution footprinting of the hepatitis C virus polymerase NS5B in complex with RNA.

Human T-lymphotropic Virus Type 1 p30 Interacts with REGγ and Modulates ATM (Ataxia Telangiectasia Mutated) to Promote Cell Survival ⬇️

Human T-lymphotropic virus type 1 p30 interacts with REGγ and ATM (Ataxia Telangiectasia Mutated) to promote cell survival

Identification and characterization of HTLV-1 HBZ post-translational modifications

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

Identification of glycosylation sites in the SU component of the Avian Sarcoma/Leukosis virus Envelope Glycoprotein (Subgroup A) by mass spectrometry

Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells

Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switch

Interactions of HIV-1 Gag with assembly cofactors

Interactions of the Disordered Domain II of Hepatitis C Virus NS5A with Cyclophilin A, NS5B, and Viral RNA Show Extensive Overlap

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA.

Mass spectrometry-based footprinting of protein-protein interactions

Methods for Identifying and Examining HTLV-1 HBZ Post-translational Modifications

Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase

Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.

Molecular mechanisms of retroviral integration site selection

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

N6-methyladenosine Binding Proteins Negatively Regulate HIV-1 Infectivity and Viral Production

Nonpolar thymine isosteres in the Ty3 polypurine tract DNA template modulate processing and provide a model for its recognition by Ty3 reverse transcriptase

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase

Probing conformational changes of human DNA polymerase lambda using mass spectrometry-based protein footprinting

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol proteolytic processing

Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

Structural Studies and Biological Evaluation of T30695 Variants Modified with Single Chiral Glycerol-T Reveal the Importance of LEDGF/p75 for the Aptamer Anti-HIV-Integrase Activities

Structural analysis of protein-RNA interactions with mass spectrometry

Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding

TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency

The FACT Complex Promotes Avian Leukosis Virus DNA Integration

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity