Lista de obras - Neil Kelleher - Dominio Público Uruguay

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

artículo científico publicado en 2020

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

A community resource for paired genomic and metabolomic data mining

artículo científico publicado en 2021

A comprehensive pipeline for translational top-down proteomics from a single blood draw

artículo científico publicado en 2019

A computational framework to explore large-scale biosynthetic diversity

scientific article published on 25 November 2019

A five-level classification system for proteoform identifications

scientific article published on 01 October 2019

A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

artículo científico publicado en 2022

A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome

artículo científico publicado en 2009

A scalable platform to identify fungal secondary metabolites and their gene clusters ⬇️

artículo científico publicado en 2017

A synthetic biology approach to probing nucleosome symmetry.

artículo científico publicado en 2017

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

scholarly article by Luca Fornelli et al published 17 July 2018 in Analytical Chemistry

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

artículo científico

An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes

artículo científico publicado en 2020

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

artículo científico publicado en 2018

An informatic framework for decoding protein complexes by top-down mass spectrometry

artículo científico publicado en 2016

An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes

scholarly article

Analysis of intact protein isoforms by mass spectrometry.

artículo científico publicado en 2011

Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins

artículo científico publicado en 2014

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

scientific article published on 27 June 2019

CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids.

artículo científico publicado en 2018

Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria

artículo científico publicado en 2018

Characterization of proteomic and metabolomic responses to dietary factors and supplements

artículo científico publicado en 2007

Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools.

artículo científico publicado en 2017

Chromatographic efficiency and selectivity in top-down proteomics of histones

artículo científico publicado en 2016

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.

artículo científico publicado en 2017

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection.

scientific article published on 27 April 2016

Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover

artículo científico publicado en 2017

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes

scientific article published on 08 July 2019

Deep and quantitative top-down proteomics in clinical and translational research

artículo científico publicado en 2014

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry

artículo científico publicado en 2017

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

scientific article published on 27 June 2019

Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform

artículo científico publicado en 2015

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

artículo científico publicado en 2019

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

artículo científico publicado en 2020

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics. ⬇️

artículo científico publicado en 2018

Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.

artículo científico publicado en 2017

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

scientific article published on 28 January 2020

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations. ⬇️

artículo científico publicado en 2016

Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry

article

Evaluation of the compact high-field orbitrap for top-down proteomics of human cells

artículo científico publicado en 2012

Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein.

artículo científico publicado en 2017

Fragmentation of integral membrane proteins in the gas phase

artículo científico publicado en 2014

From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry.

artículo científico publicado en 2013

Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster

artículo científico publicado en 2020

Global amine and acid functional group modification of proteins

artículo científico publicado en 2008

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer

artículo científico publicado en 2017

High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides

artículo científico publicado en 2012

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture ⬇️

artículo científico publicado en 2020

How many human proteoforms are there?

artículo científico publicado en 2018

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry.

artículo científico publicado en 2016

Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.

artículo científico publicado en 2018

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry

artículo científico publicado en 2020

Intact mass detection, interpretation, and visualization to automate Top‐Down proteomics on a large scale ⬇️

artículo científico publicado el 1 de octubre de 2010

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts

artículo científico publicado en 2015

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

artículo científico publicado en 2020

Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

artículo científico publicado en 2018

Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry

artículo científico publicado en 2020

Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

artículo científico publicado en 2013

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics

artículo científico publicado en 2016

Mapping intact protein isoforms in discovery mode using top-down proteomics

artículo científico publicado en 2011

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis

artículo científico publicado en 2015

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

artículo científico publicado en 2019

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

artículo científico publicado en 2015

Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid

scientific article published on 28 June 2019

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

artículo científico publicado en 2021

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism To Achieve N2 Reduction

scientific article published on 19 July 2019

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol

artículo científico publicado en 2019

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

artículo científico publicado en 2020

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.

artículo científico publicado en 2017

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

artículo científico publicado en 2020

Nano-LC FTICR Tandem Mass Spectrometry for Top-Down Proteomics: Routine Baseline Unit Mass Resolution of Whole Cell Lysate Proteins up to 72 kDa ⬇️

artículo científico publicado el 22 de febrero de 2012

Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin.

artículo científico publicado en 2017

Native GELFrEE: a new separation technique for biomolecular assemblies

artículo científico publicado en 2015

Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics

artículo científico publicado en 2022

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase.

artículo científico publicado en 2019

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions

scientific article published on 04 February 2020

Natural products from thioester reductase containing biosynthetic pathways

artículo científico publicado en 2018

Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire

artículo científico publicado en 2021

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry

artículo científico publicado en 2020

On the scalability and requirements of whole protein mass spectrometry

artículo científico publicado en 2011

Oncogene-induced cellular senescence elicits an anti-Warburg effect

artículo científico publicado en 2013

Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells

artículo científico publicado en 2021

Online matrix removal platform for coupling gel-based separations to whole protein electrospray ionization mass spectrometry

artículo científico publicado en 2015

Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins

artículo científico publicado en 2014

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

artículo científico publicado en 2018

ProForma: A Standard Proteoform Notation.

artículo científico publicado en 2018

Probing Asymmetric Charge Partitioning of Protein Oligomers during Tandem Mass Spectrometry

artículo científico publicado en 2015

Proteomics Standards Initiative's ProForma 2.0: Unifying the Encoding of Proteoforms and Peptidoforms

artículo científico publicado en 2022

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms

scientific article published on 22 November 2019

Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics

artículo científico publicado en 2015

Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins.

artículo científico publicado en 2018

Robust Analysis of the Yeast Proteome under 50 kDa by Molecular-Mass-Based Fractionation and Top-Down Mass Spectrometry ⬇️

artículo científico publicado el 14 de diciembre de 2011

Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.

artículo científico publicado en 2017

Site-specific human histone H3 methylation stability: fast K4me3 turnover

artículo científico publicado en 2014

Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa

artículo científico publicado en 2010

Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging

artículo científico publicado en 2021

Spinning up mass spectrometry for whole protein complexes

article published in 2012

Standard Proteoforms and Their Complexes for Native Mass Spectrometry

artículo científico publicado en 2019

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ.

artículo científico publicado en 2017

Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval

artículo científico publicado en 2009

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry

artículo científico publicado en 2015

Targeted detection and quantitation of histone modifications from 1,000 cells

scientific article published on 26 October 2020

The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms

artículo científico publicado en 2022

The Mechanism of N2 Reduction Catalyzed by Fe-Nitrogenase Involves Reductive Elimination of H2.

artículo científico publicado en 2017

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins

artículo científico publicado en 2018

The biosynthesis of methanobactin.

artículo científico publicado en 2018

The emergence of top-down proteomics in clinical research

artículo científico publicado en 2013

The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput

artículo científico publicado en 2010

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.

artículo científico publicado en 2017

Thorough Performance Evaluation of 213 nm Ultraviolet Photodissociation for Top-down Proteomics

artículo científico publicado en 2019

Top Down proteomics: facts and perspectives

artículo científico publicado en 2014

Top down proteomics of human membrane proteins from enriched mitochondrial fractions

artículo científico publicado en 2013

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

artículo científico publicado en 2018

Top-down characterization of endogenous protein complexes with native proteomics

artículo científico publicado en 2017

Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers

artículo científico publicado en 2007

Top-down proteomics reveals novel protein forms expressed in Methanosarcina acetivorans

artículo científico publicado en 2009

Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders

artículo científico publicado en 2014

Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization.

artículo científico publicado en 2018

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

artículo científico publicado en 2012

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression

artículo científico publicado en 2015

Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra

artículo científico publicado en 2008

Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis

scientific article published on 24 February 2020

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site

artículo científico publicado en 2018

Lista de obras de Neil Kelleher

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

A community resource for paired genomic and metabolomic data mining

A comprehensive pipeline for translational top-down proteomics from a single blood draw

A computational framework to explore large-scale biosynthetic diversity

A five-level classification system for proteoform identifications

A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome

A scalable platform to identify fungal secondary metabolites and their gene clusters ⬇️

A synthetic biology approach to probing nucleosome symmetry.

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

An informatic framework for decoding protein complexes by top-down mass spectrometry

An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes

Analysis of intact protein isoforms by mass spectrometry.

Autopilot: an online data acquisition control system for the enhanced high-throughput characterization of intact proteins

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

CN-GELFrEE - Clear Native Gel-eluted Liquid Fraction Entrapment Electrophoresis

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids.

Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria

Characterization of proteomic and metabolomic responses to dietary factors and supplements

Characterizing the Structure and Oligomerization of Major Royal Jelly Protein 1 (MRJP1) by Mass Spectrometry and Complementary Biophysical Tools.

Chromatographic efficiency and selectivity in top-down proteomics of histones

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection.

Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes

Deep and quantitative top-down proteomics in clinical and translational research

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics. ⬇️

Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.

Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations. ⬇️

Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry

Evaluation of the compact high-field orbitrap for top-down proteomics of human cells

Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein.

Fragmentation of integral membrane proteins in the gas phase

From protein complexes to subunit backbone fragments: a multi-stage approach to native mass spectrometry.

Genome Mining and Metabolomics Uncover a Rare d-Capreomycidine Containing Natural Product and Its Biosynthetic Gene Cluster

Global amine and acid functional group modification of proteins

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer

High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture ⬇️

How many human proteoforms are there?

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry.

Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry

Intact mass detection, interpretation, and visualization to automate Top‐Down proteomics on a large scale ⬇️

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry

Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics

Mapping intact protein isoforms in discovery mode using top-down proteomics

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

Mo-, V-, and Fe-Nitrogenases Use a Universal Eight-Electron Reductive-Elimination Mechanism To Achieve N2 Reduction

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

Nano-LC FTICR Tandem Mass Spectrometry for Top-Down Proteomics: Routine Baseline Unit Mass Resolution of Whole Cell Lysate Proteins up to 72 kDa ⬇️

Native Electron Capture Dissociation Maps to Iron-Binding Channels in Horse Spleen Ferritin.

Native GELFrEE: a new separation technique for biomolecular assemblies

Native Mass Spectrometry at the Convergence of Structural Biology and Compositional Proteomics

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase.

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions

Natural products from thioester reductase containing biosynthetic pathways

Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire