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A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

artículo científico publicado en 2016

A simple method for the isolation of genomic DNA from mouse tail free of real-time PCR inhibitors

artículo científico publicado en 2002

A xenograft model of infant leukaemia reveals a complex MLL translocation

artículo científico publicado en 2008

ABC transporters as mediators of drug resistance and contributors to cancer cell biology.

artículo científico publicado en 2016

ABC transporters in cancer: more than just drug efflux pumps.

artículo científico publicado en 2010

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer

artículo científico publicado en 2014

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

scientific article published on August 2013

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

artículo científico publicado en 2011

ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.

artículo científico publicado en 2011

ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells.

artículo científico publicado en 2009

Absence of MEN2A- or 2B-typeRETmutations in primary neuroblastoma tumour tissue

artículo científico publicado en 1998

Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.

artículo científico publicado en 2007

Alcoholic pancreatitis and polymorphisms of the variable length polythymidine tract in the cystic fibrosis gene

artículo científico publicado en 1999

An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro

scientific article published on 01 October 1995

Association of N-myc amplification with neuroblastoma: the Australian and New Zealand experience

artículo científico publicado el 1 de febrero de 1992

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

artículo científico publicado en 2007

Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia.

artículo científico publicado en 2009

Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)

artículo científico publicado en 2003

Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells.

artículo científico publicado en 2003

Determination of N-myc gene amplification in neuroblastoma by differential polymerase chain reaction

article

Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia.

artículo científico publicado en 2009

Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth

scientific article published on 21 June 2016

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

scientific article published on 09 September 2019

Early responses to chemotherapy of normal and malignant hematologic cells are prognostic in children with acute lymphoblastic leukemia.

artículo científico publicado en 2005

Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma

article

Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.

artículo científico publicado en 2005

Expression of the putative tumour suppressor gene,p73, in neuroblastoma and other childhood tumours

article

Favorable prognostic significance of high-level retinoic acid receptor beta expression in neuroblastoma mediated by effects on cell cycle regulation.

artículo científico publicado en 1998

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

artículo científico publicado en 2016

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

artículo científico publicado en 2016

Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter

artículo científico publicado en 2003

HLA-G polymorphisms, genetic susceptibility, and clinical outcome in childhood neuroblastoma

scientific article published on 03 October 2011

High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance.

artículo científico publicado en 2001

High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation.

artículo científico publicado en 2013

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

artículo científico publicado en 2014

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

artículo científico publicado en 2014

Importance of minimal residual disease testing during the second year of therapy for children with acute lymphoblastic leukemia.

artículo científico publicado en 2003

Improved PCR assay for the detection of antigen receptor gene rearrangements

scientific article published on 01 December 1997

Improving minimal residual disease detection in precursor B-ALL based on immunoglobulin-kappa and heavy-chain gene rearrangements

artículo científico publicado en 2008

Improving the identification of high risk precursor B acute lymphoblastic leukemia patients with earlier quantification of minimal residual disease

artículo científico publicado en 2013

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

artículo científico publicado en 2019

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

artículo científico publicado en 1996

Isolated testicular relapse after allo-SCT in boys with ALL: outcome without second transplant

artículo científico publicado en 2009

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

artículo científico publicado en 2019

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.

artículo científico publicado en 2018

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cells

artículo científico publicado en 2001

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

scientific article published on 11 July 2019

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

artículo científico publicado en 2016

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

artículo científico publicado en 2015

MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN

scientific article published on 01 November 2000

MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma.

artículo científico publicado en 2004

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

artículo científico publicado en 2018

Mechanism of relapse in pediatric acute lymphoblastic leukemia.

artículo científico publicado en 2008

Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.

scholarly article

N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

artículo científico publicado en 2011

N-myc amplification in Wilms' tumor

artículo científico publicado en 1988

Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol.

artículo científico publicado en 2009

Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors.

artículo científico publicado en 2009

P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene ⬇️

artículo científico publicado el 5 de octubre de 1998

PCR for monoclonal gene rearrangements can differentiate infantile acute lymphoblastic leukemia from cytomegalovirus infection

artículo científico publicado en 2005

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.

artículo científico publicado en 2009

Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma

artículo científico publicado en 2007

Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia

artículo científico publicado en 2019

Prognostic significance of MYCN oncogene expression in childhood neuroblastoma

artículo científico publicado en 1998

Prognostic significance of promoter DNA methylation in patients with childhood neuroblastoma

artículo científico publicado en 2012

Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia

artículo científico publicado en 2009

Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone

artículo científico publicado en 2007

Resistance to tetracycline, a hydrophilic antibiotic, is mediated by P-glycoprotein in human multidrug-resistant cells.

artículo científico publicado en 1993

Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.

artículo científico publicado en 2002

Sensitive non-radioactive PCR detection of clonal T-cell receptor-gamma gene rearrangements in childhood acute lymphoblastic leukaemia

scientific article published on 01 September 1997

Simultaneous detection and quantification of minimal residual disease in childhood acute lymphoblastic leukaemia using real-time polymerase chain reaction

scientific article published on 01 May 2000

Single-strand-specific degradation of DNA during isolation of rat liver nuclei

scientific article published on 01 October 1985

Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression

artículo científico publicado en 2020

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

artículo científico publicado en 2017

Synergy between 5′ and 3′ flanking regions of the human tyrosine hydroxylase gene ensures specific, high-level expression in neuroblastoma cells

article

TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells

artículo científico publicado en 2010

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

artículo científico publicado en 2020

Targeting TSLP-induced tyrosine kinase signaling pathways in CRLF2-rearranged Ph-like ALL

scientific article published on 14 August 2020

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes ⬇️

artículo científico publicado el 1 de septiembre de 1997

The estrogen-responsive B box protein is a novel regulator of the retinoid signal

artículo científico publicado en 2006

The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression

artículo científico publicado en 2016

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

artículo científico publicado en 2019

The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

scientific article published on 01 June 2002

The p53 pathway and its inactivation in neuroblastoma.

artículo científico publicado en 2003

The prognostic value of MDR1 gene expression in primary untreated neuroblastoma

artículo científico publicado en 1997

Too many targets, not enough patients: rethinking neuroblastoma clinical trials.

artículo científico publicado en 2018

Two cases of hypereosinophilia and high-risk acute lymphoblastic leukemia

artículo científico publicado en 2008

c-MYC oncoprotein dictates transcriptional profiles of ATP-binding cassette transporter genes in chronic myelogenous leukemia CD34+ hematopoietic progenitor cells.

artículo científico publicado en 2011

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.

artículo científico publicado en 2010

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