Lista de obras - Nancy Rothwell - Dominio Público Uruguay

100 NF-κB Activation by Mal/Tirap is Regulated by Caspase-1

scholarly article by Sinead M. Miggin et al published July 2007 in Cytokine

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

artículo científico publicado en 2015

A dual role for interleukin-1 in LTP in mouse hippocampal slices

artículo científico publicado en 2003

A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

artículo científico publicado en 2009

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

artículo científico publicado en 2007

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

artículo científico publicado en 2015

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection.

artículo científico publicado en 2013

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

artículo científico publicado en 2003

An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood-brain barrier model

artículo científico publicado en 2012

Animal experiments and the development of surgical therapies

scientific article published on 01 January 2005

Animal experiments and the doctor

scientific article published on 01 October 2002

Boron-Based Inhibitors of the NLRP3 Inflammasome

artículo científico publicado en 2017

Brain inflammation is induced by co-morbidities and risk factors for stroke

artículo científico publicado en 2011

CNS injury: the role of the cytokine IL-1.

artículo científico publicado en 2004

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages

artículo científico publicado en 2003

Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

artículo científico publicado en 2007

Caspases Mediate 6-Hydroxydopamine-Induced Apoptosis but Not Necrosis in PC12 Cells

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

artículo científico publicado en 2013

Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection.

artículo científico publicado en 2012

Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system

artículo científico publicado en 2015

Choices in neuroscience careers

artículo científico publicado en 2008

Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice

artículo científico publicado en 2010

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

artículo científico publicado en 2005

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

artículo científico publicado en 2007

Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients.

artículo científico publicado en 2004

Cytokines in the Nervous System

Dear diary..

scientific article published in Nature

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

artículo científico publicado en 2003

Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

artículo científico publicado en 2012

Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways

scientific journal article

Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones

artículo científico publicado en 2008

Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study

artículo científico publicado en 2011

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

artículo científico publicado en 2016

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

artículo científico publicado en 2011

Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.

artículo científico publicado en 2003

Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses

artículo científico publicado en 2010

Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells

artículo científico publicado en 2002

Extracellular ATP and P2X7 receptors in neurodegeneration

artículo científico publicado en 2002

Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain

artículo científico publicado en 2006

IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice

artículo científico publicado en 2002

IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells

artículo científico publicado en 2003

Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain

scientific journal article

Improving outcome after stroke: overcoming the translational roadblock

artículo científico publicado en 2008

Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

artículo científico

Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

scientific article published on 05 September 2012

Inflammation in central nervous system injury

artículo científico publicado en 2003

Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra

artículo científico publicado en 2007

Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

scientific journal article

Interleukin-1 and neuronal injury

artículo científico publicado en 2005

Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential ⬇️

artículo científico publicado el 1 de junio de 2003

Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target

artículo científico publicado en 2011

Interleukin-1 as a pharmacological target in acute brain injury

artículo científico

Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways

artículo científico publicado en 2010

Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat.

artículo científico publicado en 2008

Interleukin-1 in Stroke: From Bench to Bedside

artículo científico publicado en 2016

Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.

artículo científico publicado en 2002

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis

artículo científico publicado en 2012

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

artículo científico publicado en 2017

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

artículo científico publicado en 2012

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

artículo científico publicado en 2007

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression

artículo científico publicado en 2012

Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release

artículo científico publicado en 2006

Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta

artículo científico publicado en 2003

Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

artículo científico publicado en 2011

Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent

artículo científico publicado en 2002

Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism

artículo científico

Long-term functional recovery and compensation after cerebral ischemia in rats

artículo científico publicado en 2014

Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity

scientific journal article

Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones

artículo científico publicado en 2008

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

artículo científico publicado en 2013

Modeling Risk Factors and Confounding Effects in Stroke

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

artículo científico publicado en 2007

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

artículo científico publicado en 2012

Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro

scientific journal article

Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.

artículo científico publicado en 2006

Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling

artículo científico publicado en 2005

Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA.

artículo científico publicado en 2012

No paradox in the control of energy intake (reply)

artículo científico publicado en 1978

No role for interleukin-18 in acute murine stroke-induced brain injury

artículo científico publicado en 2003

One more thing...

artículo científico publicado en 2004

PRL-releasing peptide interacts with leptin to reduce food intake and body weight

artículo científico publicado en 2002

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

artículo científico publicado en 2009

Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

artículo científico publicado en 2004

Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage

artículo científico publicado en 2007

Platelet interleukin-1alpha drives cerebrovascular inflammation

artículo científico publicado en 2010

Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke

artículo científico publicado en 2009

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production

artículo científico publicado en 2001

Psychoneuroimmunology of stroke

artículo científico publicado en 2009

Psychoneuroimmunology of stroke

artículo científico publicado en 2006

Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism

artículo científico publicado en 2002

Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection

artículo científico publicado en 2010

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study.

artículo científico publicado en 2017

Regulation of expression of the novel IL-1 receptor family members in the mouse brain

scientific article published on 08 August 2005

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death

artículo científico publicado en 2014

Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia

artículo científico publicado en 2016

Requirement for interleukin-1 to drive brain inflammation reveals tissue-specific mechanisms of innate immunity.

artículo científico publicado en 2014

Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures

artículo científico publicado en 2002

Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo

artículo científico publicado en 2003

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial

scientific article published on 22 March 2018

Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum

artículo científico publicado en 2002

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming

artículo científico publicado en 2018

Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

artículo científico publicado en 2014

Study design and population pharmacokinetic analysis of a phase II dose-ranging study of interleukin-1 receptor antagonist

artículo científico publicado en 2015

Surgical manipulation compromises leukocyte mobilization responses and inflammation after experimental cerebral ischemia in mice

artículo científico publicado en 2013

Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.

artículo científico publicado en 2008

Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms

artículo científico publicado en 2007

The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury

scientific article published on 18 December 2013

The dynamics and mechanisms of interleukin-1alpha and beta nuclear import

artículo científico publicado en 2008

The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial.

artículo científico publicado en 2014

The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain?

artículo científico publicado en 2003

The influence of litter size on brain damage caused by hypoxic-ischemic injury in the neonatal rat.

artículo científico publicado en 2002

The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses

artículo científico publicado en 2005

The role of inflammation in CNS injury and disease

artículo científico publicado en 2006

Translational pharmacokinetics: challenges of an emerging approach to drug development in stroke.

artículo científico publicado en 2011

Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS

scientific journal article

Variability of the systemic acute phase response after ischemic stroke

artículo científico publicado en 2006

[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats

artículo científico publicado en 2013

Lista de obras de Nancy Rothwell

100 NF-κB Activation by Mal/Tirap is Regulated by Caspase-1

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke

A dual role for interleukin-1 in LTP in mouse hippocampal slices

A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection.

An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis

An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood-brain barrier model

Animal experiments and the development of surgical therapies

Animal experiments and the doctor

Boron-Based Inhibitors of the NLRP3 Inflammasome

Brain inflammation is induced by co-morbidities and risk factors for stroke

CNS injury: the role of the cytokine IL-1.

Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages

Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Caspases Mediate 6-Hydroxydopamine-Induced Apoptosis but Not Necrosis in PC12 Cells

Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice

Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection.

Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system

Choices in neuroscience careers

Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients.

Cytokines in the Nervous System

Dear diary..

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways

Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones

Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.

Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses

Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells

Extracellular ATP and P2X7 receptors in neurodegeneration

Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain

IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice

IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells

Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain

Improving outcome after stroke: overcoming the translational roadblock

Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage

Inflammation in central nervous system injury

Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra

Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

Interleukin-1 and neuronal injury

Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential ⬇️

Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target

Interleukin-1 as a pharmacological target in acute brain injury

Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways

Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat.

Interleukin-1 in Stroke: From Bench to Bedside

Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons

Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations

Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression

Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release

Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta

Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent

Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism

Long-term functional recovery and compensation after cerebral ischemia in rats

Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity

Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.

Modeling Risk Factors and Confounding Effects in Stroke

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro

Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.

Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling

Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA.

No paradox in the control of energy intake (reply)