Lista de obras -

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

artículo científico publicado en 2014

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt ⬇️

artículo científico publicado el 8 de mayo de 2012

Characterization of the microtubule movement produced by sea urchin egg kinesin

artículo científico publicado en 1987

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

artículo científico publicado en 2010

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors ⬇️

artículo científico publicado el 18 de septiembre de 2012

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

artículo científico publicado en 2014

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

scientific article published on 07 November 2018

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease

artículo científico publicado en 2014

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

artículo científico publicado en 2010

Discovery of pyrrolopyrimidine inhibitors of Akt

artículo científico publicado en 2010

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

artículo científico publicado en 2011

Electron microscopy of frozen-hydrated biological material

artículo científico publicado en 1986

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase

artículo científico publicado en 2014

Location of the 100 kd-50 kd accessory proteins in clathrin coats.

artículo científico publicado en 1986

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

artículo científico publicado en 1995

Multiple active site corrections for docking and virtual screening.

artículo científico publicado en 2004

Non-charged thiamine analogs as inhibitors of enzyme transketolase.

artículo científico publicado en 2007

Non-oxime inhibitors of B-Raf(V600E) kinase

artículo científico publicado en 2011

Potent selective nonpeptidic inhibitors of human lung tryptase.

artículo científico publicado en 1999

Regulation of nuclear envelope precursor functions during cell division

artículo científico publicado el 1 de junio de 1992

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species

artículo científico publicado en 2013

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

artículo científico publicado en 2014

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

artículo científico publicado en 2007

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

artículo científico publicado en 2011

Three-dimensional structure of clathrin cages in ice.

artículo científico publicado en 1986

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution

artículo científico publicado en 1994

Lista de obras de

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt ⬇️

Characterization of the microtubule movement produced by sea urchin egg kinesin

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors ⬇️

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Discovery of pyrrolopyrimidine inhibitors of Akt

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

Electron microscopy of frozen-hydrated biological material

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase

Location of the 100 kd-50 kd accessory proteins in clathrin coats.

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

Multiple active site corrections for docking and virtual screening.

Non-charged thiamine analogs as inhibitors of enzyme transketolase.

Non-oxime inhibitors of B-Raf(V600E) kinase

Potent selective nonpeptidic inhibitors of human lung tryptase.

Regulation of nuclear envelope precursor functions during cell division

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Three-dimensional structure of clathrin cages in ice.

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution