Lista de obras - Wenyi Wei - Dominio Público Uruguay

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

artículo científico publicado en 2017

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

artículo científico publicado en 2019

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

artículo científico publicado en 2014

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

artículo científico publicado en 2017

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

artículo científico publicado en 2020

Acetylation-dependent regulation of Skp2 function

artículo científico publicado en 2012

An Evolving Role for DEPTOR in Tumor Development and Progression ⬇️

artículo científico publicado el 1 de mayo de 2012

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 01 May 2019

Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

artículo científico publicado en 2020

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

artículo científico publicado en 2014

Cdc20: a potential novel therapeutic target for cancer treatment

artículo científico publicado en 2013

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

artículo científico publicado en 2016

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways

scientific article published on 28 May 2009

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid

artículo científico publicado en 2016

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

artículo científico publicado en 2011

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

artículo científico publicado en 2014

Cyclin C is a haploinsufficient tumour suppressor

artículo científico publicado en 2014

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction ⬇️

artículo científico publicado el 1 de septiembre de 2012

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma

artículo científico publicado en 2020

Degrading proteins in animals: "PROTAC"tion goes in vivo

artículo científico publicado en 2019

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation ⬇️

artículo científico publicado el 23 de diciembre de 2011

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis

artículo científico publicado en 2014

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair.

artículo científico publicado en 2018

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

artículo científico publicado en 2020

Light-induced control of protein destruction by opto-PROTAC

artículo científico publicado en 2020

MC1R is a potent regulator of PTEN after UV exposure in melanocytes

artículo científico publicado en 2013

Mcl-1 ubiquitination and destruction

artículo científico publicado en 2011

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

artículo científico publicado en 2018

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase ⬇️

artículo científico publicado el 17 de mayo de 2012

Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction

artículo científico publicado en 2010

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

artículo científico publicado en 2009

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

artículo científico publicado en 2010

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

scientific article published on 01 May 2019

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction ⬇️

artículo científico publicado el 10 de septiembre de 2010

Roles of F-box proteins in cancer

artículo científico publicado en 2014

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

scientific article published on December 2013

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

artículo científico publicado en 2011

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

artículo científico publicado en 2012

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

artículo científico publicado en 2015

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

artículo científico publicado en 2012

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

artículo científico publicado en 2014

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

artículo científico publicado en 2013

SCF-mediated degradation of Brg1 suppresses gastric cancer metastasis

artículo científico publicado en 2018

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

artículo científico publicado en 2014

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer

artículo científico publicado en 2014

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

artículo científico publicado en 2013

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

artículo científico publicado en 2020

Skp2 is a promising therapeutic target in breast cancer

artículo científico publicado en 2012

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

artículo científico publicado en 2018

Skp2: A novel potential therapeutic target for prostate cancer ⬇️

artículo científico publicado el 22 de septiembre de 2011

TF-PROTACs Enable Targeted Degradation of Transcription Factors

artículo científico publicado en 2021

Targeting Cdc20 as a novel cancer therapeutic strategy

artículo científico publicado en 2015

Targeting the ubiquitin pathway for cancer treatment

artículo científico publicado en 2015

The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

scientific article published on 24 April 2020

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

artículo científico publicado en 2017

The diverse roles of SPOP in prostate cancer and kidney cancer

scientific article published on 30 April 2020

The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. ⬇️

artículo científico publicado en 2018

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

artículo científico publicado en 2018

The role of ubiquitination in tumorigenesis and targeted drug discovery

scientific article published on 29 February 2020

The two faces of FBW7 in cancer drug resistance.

artículo científico publicado en 2011

Tumor suppressor functions of FBW7 in cancer development and progression ⬇️

artículo científico publicado el 21 de marzo de 2012

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

artículo científico publicado en 2022

Ubiquitin signaling in cell cycle control and tumorigenesis

artículo científico publicado en 2020

WWP1 germline variants are associated with normocephalic autism spectrum disorder

artículo científico publicado en 2020

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

artículo científico publicado en 2011

Lista de obras de Wenyi Wei

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

Acetylation-dependent regulation of Skp2 function

An Evolving Role for DEPTOR in Tumor Development and Progression ⬇️

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

Cdc20: a potential novel therapeutic target for cancer treatment

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Cyclin C is a haploinsufficient tumour suppressor

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction ⬇️

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma

Degrading proteins in animals: "PROTAC"tion goes in vivo

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation ⬇️

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair.

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

Light-induced control of protein destruction by opto-PROTAC

MC1R is a potent regulator of PTEN after UV exposure in melanocytes

Mcl-1 ubiquitination and destruction

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase ⬇️

Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction ⬇️

Roles of F-box proteins in cancer

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

SCF-mediated degradation of Brg1 suppresses gastric cancer metastasis

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

Skp2 is a promising therapeutic target in breast cancer

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Skp2: A novel potential therapeutic target for prostate cancer ⬇️

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Targeting Cdc20 as a novel cancer therapeutic strategy

Targeting the ubiquitin pathway for cancer treatment

The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

The diverse roles of SPOP in prostate cancer and kidney cancer

The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. ⬇️

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

The role of ubiquitination in tumorigenesis and targeted drug discovery

The two faces of FBW7 in cancer drug resistance.

Tumor suppressor functions of FBW7 in cancer development and progression ⬇️

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

Ubiquitin signaling in cell cycle control and tumorigenesis

WWP1 germline variants are associated with normocephalic autism spectrum disorder

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR