Lista de obras - James Arthos - Dominio Público Uruguay

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

artículo científico publicado en 2016

Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.

artículo científico publicado en 2010

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

scientific article published on 10 April 2019

Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

artículo científico publicado en 2002

Blocking α4β7 integrin binding to SIV does not improve virologic control

artículo científico publicado en 2019

Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitor

artículo científico publicado en 2007

CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus Envelopes

Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility

artículo científico publicado en 2011

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

artículo científico publicado en 2018

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

artículo científico publicado en 2014

Correction for Lu et al., "Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands"

artículo científico publicado en 2020

Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

artículo científico publicado en 2016

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

artículo científico publicado en 2017

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

artículo científico publicado en 2008

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

artículo científico publicado en 2008

Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120

artículo científico publicado en 2007

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

artículo científico publicado en 2015

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

scientific article published on 13 May 2019

Design clues from functional constraints and broadly neutralizing antibodies

Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.

artículo científico publicado en 2005

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

artículo científico publicado en 2008

Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

artículo científico publicado en 2017

Functional Dynamics of the Interaction between HIV gp120 and α4β7.

artículo científico publicado en 2014

HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation

artículo científico publicado en 2016

HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication

artículo científico publicado en 2002

HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis

artículo científico publicado en 2003

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

scientific article published on 30 January 2020

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

artículo científico publicado en 2018

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

artículo científico publicado en 2008

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV ⬇️

artículo científico publicado el 27 de enero de 2011

HIV-1 gp120 Impairs B Cell Proliferation by Inducing TGF-β1 Production and FcRL4 Expression

HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells

article

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells

artículo científico publicado en 2007

HIV-1 gp120: A Target for Therapeutics and Vaccine Design.

artículo científico publicado en 2015

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

scientific article published in Nature Communications

HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection

scientific article published on 03 September 2020

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

artículo científico publicado en 2011

Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing

artículo científico publicado en 2004

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa

artículo científico publicado en 2012

Innate Immunity in HIV Infection

article

Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions

article

Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

artículo científico publicado en 2017

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

artículo científico publicado en 2018

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication

artículo científico publicado en 2018

Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype

artículo científico publicado en 2017

Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+T lymphocytes, a transcriptome analysis

article

Preferential HIV Infection of CCR6 + Th17 Cells Is Associated with Higher Levels of Virus Receptor Expression and Lack of CCR5 Ligands ⬇️

artículo científico publicado el 31 de julio de 2013

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies

artículo científico publicado en 2010

R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells

artículo científico publicado en 2006

Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs

artículo científico publicado en 2020

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

artículo científico publicado en 2017

Role of T-cell trafficking in the pathogenesis of HIV disease

scientific article published on 01 March 2019

SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution

scientific article published on 26 August 2020

Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines

artículo científico publicado en 2017

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

article

Shedding-resistant HIV-1 envelope glycoproteins adopt downstream conformations that remain responsive to conformation-preferring ligands

artículo científico publicado en 2020

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

artículo científico publicado en 2011

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

artículo científico publicado en 2018

Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

artículo científico publicado en 2020

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates

artículo científico publicado en 2015

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

artículo científico publicado en 2009

Structural basis for the interaction between focal adhesion kinase and CD4

artículo científico publicado en 2008

Structural definition of a conserved neutralization epitope on HIV-1 gp120

artículo científico publicado en 2007

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

artículo científico publicado en 2011

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy

artículo científico publicado en 2016

Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy.

artículo científico publicado en 2005

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

artículo científico publicado en 2014

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission ⬇️

artículo científico publicado el 24 de febrero de 2011

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

artículo científico publicado en 2013

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages

artículo científico publicado en 2015

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment

artículo científico publicado en 2018

The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies

artículo científico publicado en 2020

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

artículo científico publicado en 2013

The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

artículo científico publicado en 2009

The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells

artículo científico publicado en 2002

Two Closely Related Env Antigens from the Same Patient Elicited Different Spectra of Neutralizing Antibodies against Heterologous HIV-1 Isolates ⬇️

artículo científico publicado el 16 de marzo de 2011

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity

artículo científico publicado en 2014

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay

artículo científico publicado en 2014

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing

artículo científico publicado en 2017

Worldwide Genetic Features of HIV-1 Env α4β7 Binding Motif: The Local Dissemination Impact of the LDI Tripeptide

artículo científico publicado en 2015

Lista de obras de James Arthos

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

Blocking α4β7 integrin binding to SIV does not improve virologic control

Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitor

CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus Envelopes

Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

Correction for Lu et al., "Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands"

Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

Design clues from functional constraints and broadly neutralizing antibodies

Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

Functional Dynamics of the Interaction between HIV gp120 and α4β7.

HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation

HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication

HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV ⬇️

HIV-1 gp120 Impairs B Cell Proliferation by Inducing TGF-β1 Production and FcRL4 Expression

HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells

HIV-1 gp120: A Target for Therapeutics and Vaccine Design.

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa

Innate Immunity in HIV Infection

Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions

Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication

Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype

Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+T lymphocytes, a transcriptome analysis

Preferential HIV Infection of CCR6 + Th17 Cells Is Associated with Higher Levels of Virus Receptor Expression and Lack of CCR5 Ligands ⬇️

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies

R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells

Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Role of T-cell trafficking in the pathogenesis of HIV disease

SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution

Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

Shedding-resistant HIV-1 envelope glycoproteins adopt downstream conformations that remain responsive to conformation-preferring ligands

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Structural basis for the interaction between focal adhesion kinase and CD4

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy

Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy.

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission ⬇️

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment

The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells

Two Closely Related Env Antigens from the Same Patient Elicited Different Spectra of Neutralizing Antibodies against Heterologous HIV-1 Isolates ⬇️

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing