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Lista de obras de Michael M. Gottesman

A "silent" polymorphism in the MDR1 gene changes substrate specificity

scientific article (publication date: 26 January 2007)

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.

artículo científico publicado en 2015

A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein

artículo científico publicado en 2019

A dual-fluorescence high-throughput cell line system for probing multidrug resistance

artículo científico publicado en 2009

A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)

artículo científico publicado en 2005

A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells

artículo científico publicado en 2004

A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer

artículo científico publicado en 2020

Basic science: Bedrock of progress

artículo científico publicado en 2016

Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier

artículo científico publicado en 2016

Building scientific progress without borders: nanobiology and nanomedicine in China and the U.S.

scientific article published on 23 June 2009

Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells

artículo científico publicado en 2004

Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes

artículo científico publicado en 2012

Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family

artículo científico publicado en 2012

Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions.

artículo científico publicado en 2011

Codominance of cisplatin resistance in somatic cell hybrids

artículo científico publicado en 2003

Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function

scientific article published on 02 May 2019

Collateral sensitivity as a strategy against cancer multidrug resistance

artículo científico publicado en 2012

Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin

artículo científico publicado en 2011

Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.

artículo científico publicado en 2006

Contributions of microRNA dysregulation to cisplatin resistance in adenocarcinoma cells

artículo científico publicado en 2012

Correction: Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin

artículo científico publicado en 2020

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

artículo científico publicado en 2016

Defeating drug resistance in cancer

artículo científico publicado en 2006

Different roles for K+ channels in cisplatin-resistant cell lines argue against a critical role for these channels in cisplatin resistance.

artículo científico publicado en 2005

Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines

artículo científico publicado en 2008

Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cells

artículo científico publicado en 2004

Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.

artículo científico publicado en 2014

Drug resistance: still a daunting challenge to the successful treatment of AML.

artículo científico publicado en 2012

Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions

artículo científico publicado en 2005

Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance

artículo científico publicado en 2010

Endocytic recycling compartments altered in cisplatin-resistant cancer cells

artículo científico publicado en 2006

Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene

artículo científico publicado en 2007

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

artículo científico publicado en 2009

Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs

artículo científico publicado en 2015

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter.

artículo científico publicado en 2007

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

scientific article published on 21 March 2019

Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL.

artículo científico publicado en 2015

Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system.

artículo científico publicado en 2002

Heterogeneity in refractory acute myeloid leukemia

scientific article published on 07 May 2019

High cloning capacity of in vitro packaged SV40 vectors with no SV40 virus sequences.

artículo científico publicado en 2003

Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane

artículo científico publicado en 2007

Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance

artículo científico publicado en 2006

Identification of compounds selectively killing multidrug-resistant cancer cells

artículo científico publicado en 2009

Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines

artículo científico publicado en 2004

Identification of gene signatures involved in the mechanisms of multidrug resistance

artículo científico publicado en 2009

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors

artículo científico publicado en 2012

In vitro-packaged SV40 pseudovirions as highly efficient vectors for gene transfer.

artículo científico publicado en 2002

Influence of melanosome dynamics on melanoma drug sensitivity.

artículo científico publicado en 2009

Inhibition of Multidrug Resistance by SV40 Pseudovirion Delivery of an Antigene Peptide Nucleic Acid (PNA) in Cultured Cells ⬇️

artículo científico publicado el 22 de marzo de 2011

Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin ⬇️

artículo científico publicado en 2014

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma

artículo científico publicado en 2009

Is resistance useless? Multidrug resistance and collateral sensitivity

artículo científico publicado en 2009

Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer

artículo científico publicado en 2020

Lost in Translation: Regulation of ABCG2 Expression in Human Embryonic Stem Cells

artículo científico publicado en 2014

Low and high concentrations of the topo II inhibitor daunorubicin in NIH3T3 cells: reversible G2/M versus irreversible G1 and S arrest

artículo científico publicado el 1 de marzo de 2003

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

artículo científico publicado en 2013

MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer

artículo científico publicado en 2013

Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response

artículo científico publicado en 2016

Mechanisms of multidrug resistance in cancer

scientific article published on 01 January 2010

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas

artículo científico publicado en 2006

Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.

artículo científico publicado en 2010

Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistant cancer cell lines ⬇️

artículo científico publicado el 15 de septiembre de 2003

Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells.

artículo científico publicado en 2003

Modulation of Na+-Ca2+ exchanger expression by immunosuppressive drugs is isoform-specific

artículo científico publicado en 2008

Multidrug resistance in relapsed acute myeloid leukemia: evidence of biological heterogeneity

artículo científico publicado en 2013

Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma

artículo científico publicado en 2012

Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models

artículo científico publicado en 2020

Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale

artículo científico publicado en 2020

Nanoscale drug delivery platforms overcome platinum-based resistance in cancer cells due to abnormal membrane protein trafficking

artículo científico publicado en 2013

Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1

artículo científico publicado en 2012

Overlapping substrate and inhibitor specificity of human and murine ABCG2. ⬇️

artículo científico publicado en 2013

P-Glycoprotein is not present in mitochondrial membranes

artículo científico publicado en 2007

P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential.

artículo científico publicado en 2003

P-glycoprotein: from genomics to mechanism.

artículo científico publicado en 2003

Pluripotent Stem Cell Platforms for Drug Discovery

artículo científico publicado en 2018

Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells

scientific article published on 06 May 2019

Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes

artículo científico publicado en 2005

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

artículo científico publicado en 2008

Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics

artículo científico publicado en 2010

Pseudovirions as vehicles for the delivery of siRNA

artículo científico publicado en 2010

RAB8 enhances TMEM205-mediated cisplatin resistance

artículo científico publicado en 2011

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

artículo científico publicado en 2011

Reduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patients

artículo científico publicado en 2015

Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells.

artículo científico publicado en 2012

Response

Retraction of "Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin"

scientific article published on 04 February 2020

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein

artículo científico publicado en 2020

SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism

scientific article published on 22 August 2008

SV40 pseudovirions as highly efficient vectors for gene transfer and their potential application in cancer therapy.

artículo científico publicado en 2004

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, Carboplatin, and Other Platinum Complexes

artículo científico publicado en 2014

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

artículo científico publicado en 2006

Sensitive measurement of single-nucleotide polymorphism-induced changes of RNA conformation: application to disease studies

artículo científico publicado en 2012

Silent (synonymous) SNPs: should we care about them?

artículo científico publicado en 2009

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer

artículo científico publicado en 2007

Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression

scientific article published on 22 April 2019

Structure of a multidrug transporter

artículo científico publicado en 2009

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

artículo científico publicado en 2016

Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux

artículo científico publicado en 2002

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima

artículo científico publicado en 2008

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters

artículo científico publicado en 2011

Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein

artículo científico publicado en 2011

Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells

artículo científico publicado en 2009

Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models

scientific article published on 21 December 2018

Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance

artículo científico publicado en 2014

The Drug Excipient Cyclodextrin Interacts With d-Luciferin and Interferes With Bioluminescence Imaging

scientific article published on 27 January 2016

The clinical relevance of cancer cell lines.

artículo científico publicado en 2013

The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer.

artículo científico publicado en 2009

The molecular mysteries underlying P-glycoprotein-mediated multidrug resistance

artículo científico publicado en 2004

The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity

artículo científico publicado en 2014

The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy

artículo científico publicado en 2008

The sounds of silence: synonymous mutations affect function

artículo científico publicado en 2007

The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin

artículo científico publicado en 2012

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding

scientific article published in Journal of Biological Chemistry

Toward a Better Understanding of the Complexity of Cancer Drug Resistance

artículo científico publicado en 2015

Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum.

artículo científico publicado en 2005

Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro.

artículo científico publicado en 2004

Uptake of compounds that selectively kill multidrug-resistant cells: the copper transporter SLC31A1 (CTR1) increases cellular accumulation of the thiosemicarbazone NSC73306

artículo científico publicado en 2014

Useful tool to generate unidirectional deletion vectors by utilizing the star activity of BamHI in an NcoI-BamHI-XhoI cassette

artículo científico publicado en 2005

Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers

artículo científico publicado en 2015

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