Lista de obras - V Bruno - Dominio Público Uruguay

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

artículo científico publicado en 2003

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

artículo científico publicado en 2015

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

artículo científico publicado en 2001

Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes

artículo científico publicado en 1989

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

artículo científico publicado en 2009

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2014

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

artículo científico publicado en 1995

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

artículo científico publicado en 2017

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

artículo científico publicado en 2017

Antidepressant activity of fingolimod in mice.

artículo científico publicado en 2015

Beta-amyloid monomers are neuroprotective.

artículo científico publicado en 2009

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

artículo científico publicado en 2014

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

artículo científico publicado en 2015

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

artículo científico publicado en 2016

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

artículo científico publicado en 2010

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

artículo científico publicado en 2012

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

artículo científico

Early defect of transforming growth factor β1 formation in Huntington's disease.

artículo científico publicado en 2011

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

artículo científico publicado en 2004

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

artículo científico publicado en 2008

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

artículo científico publicado en 2008

Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease

artículo científico publicado en 2020

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

artículo científico publicado en 2016

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

artículo científico publicado en 2017

Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

scientific article published on 01 November 1989

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

artículo científico publicado en 2017

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

artículo científico publicado en 2009

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

artículo científico publicado en 1999

Growth conditions differentially affect the constitutive expression of primary response genes in cultured cerebellar granule cells.

artículo científico publicado en 1995

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

artículo científico publicado en 2005

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

artículo científico publicado en 2011

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

artículo científico publicado en 2008

Inositol hexakisphosphate (phytic acid) enhances Ca2+ influx and D-[3H]aspartate release in cultured cerebellar neurons

artículo científico publicado en 1989

Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures.

artículo científico publicado en 1991

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

artículo científico publicado en 2006

Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.

artículo científico publicado en 2005

Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes

article

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

artículo científico publicado en 2010

Metabotropic glutamate receptors as drug targets: what's new?

artículo científico publicado en 2014

Metabotropic glutamate receptors in glial cells.

artículo científico publicado en 2008

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

artículo científico

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

artículo científico publicado en 1996

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

artículo científico publicado en 2007

Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes

scientific journal article

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

artículo científico publicado en 2004

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

artículo científico publicado en 2012

Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.

artículo científico publicado en 2007

Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

artículo científico publicado en 2001

Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture

artículo científico publicado en 2000

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 r

artículo científico publicado en 1999

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

artículo científico publicado en 2017

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

artículo científico publicado en 2006

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

artículo científico publicado en 2006

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

artículo científico publicado en 2005

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.

artículo científico publicado en 2007

Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons

artículo científico publicado en 1994

Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.

artículo científico publicado en 1994

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

artículo científico publicado en 2010

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

artículo científico publicado en 2011

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

artículo científico publicado en 2003

Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.

artículo científico publicado en 1998

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

artículo científico publicado en 2000

Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

artículo científico publicado en 2008

Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs

artículo científico publicado en 2000

Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents

scientific article published on 01 March 2000

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

artículo científico publicado en 2009

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

artículo científico publicado en 2010

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

artículo científico publicado en 2015

Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.

artículo científico publicado en 2004

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

artículo científico publicado en 2008

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases.

scientific article published on January 2011

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

artículo científico publicado en 2016

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

artículo científico publicado en 2007

Thyrotropin releasing hormone (TRH) and its analog, RGH-2202, accelerate maturation of cerebellar neurons in vitro

artículo científico publicado el 23 de octubre de 1992

Transcriptomic Analysis Reveals Abnormal Expression of Prion Disease Gene Pathway in Brains from Patients with Autism Spectrum Disorders

scientific article published on 29 March 2020

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

artículo científico publicado en 2015

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling.

artículo científico publicado en 2016

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

artículo científico publicado en 2017

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

artículo científico publicado en 2015

Lista de obras de V Bruno

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?

Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Antidepressant activity of fingolimod in mice.

Beta-amyloid monomers are neuroprotective.

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

Early defect of transforming growth factor β1 formation in Huntington's disease.

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

Exploratory Analysis of iPSCS-Derived Neuronal Cells as Predictors of Diagnosis and Treatment of Alzheimer Disease

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Gangliosides attenuate NHDA receptor-mediated excitatory amino acid release in cultured cerebellar neurons

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

Growth conditions differentially affect the constitutive expression of primary response genes in cultured cerebellar granule cells.

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

Inositol hexakisphosphate (phytic acid) enhances Ca2+ influx and D-[3H]aspartate release in cultured cerebellar neurons

Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures.

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.

Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

Metabotropic glutamate receptors as drug targets: what's new?

Metabotropic glutamate receptors in glial cells.

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic neuronal death in mixed mouse cortical cultures.

Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 r

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.

Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons

Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs

Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

Testosterone amplifies excitotoxic damage of cultured oligodendrocytes.

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases.

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

Thyrotropin releasing hormone (TRH) and its analog, RGH-2202, accelerate maturation of cerebellar neurons in vitro

Transcriptomic Analysis Reveals Abnormal Expression of Prion Disease Gene Pathway in Brains from Patients with Autism Spectrum Disorders

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling.

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia