Lista de obras - K Kaupmann - Dominio Público Uruguay

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

artículo científico publicado en 2011

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

artículo científico publicado en 2005

Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice.

artículo científico publicado en 2004

Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors

artículo científico publicado en 2004

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

article

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

artículo científico publicado en 2004

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

artículo científico publicado en 2006

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

artículo científico publicado en 2014

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

artículo científico publicado en 2017

Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

artículo científico publicado en 2011

C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

artículo científico publicado en 2001

Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit

artículo científico publicado en 2000

Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor

artículo científico publicado en 2003

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

artículo científico publicado en 2015

Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1.

artículo científico publicado en 1993

Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, migfbp-2 ⬇️

artículo científico publicado el 28 de febrero de 1993

Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.

artículo científico publicado en 2005

Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain.

artículo científico publicado en 1998

Differential compartmentalization and distinct functions of GABAB receptor variants

artículo científico publicado en 2006

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

artículo científico publicado en 2015

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

artículo científico publicado en 2020

Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain

artículo científico publicado en 1993

Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.

artículo científico publicado en 2005

Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

artículo científico publicado en 2001

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.

artículo científico publicado en 2010

Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.

artículo científico publicado en 1994

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

artículo científico publicado en 2006

GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine

artículo científico publicado en 2006

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

artículo científico publicado en 1998

GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation

artículo científico publicado en 2007

GABAB receptors - the first 7TM heterodimers.

artículo científico publicado en 1999

GABAB receptors: drugs meet clones.

artículo científico publicado en 1998

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

artículo científico publicado en 2006

Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.

artículo científico publicado en 1999

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.

artículo científico publicado en 2006

Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.

artículo científico publicado en 2004

Heteromerization of GABAB Receptors: A New Principle for G Protein-Coupled Receptors. Satellite Symposium to the 28th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5-7, 1998.

artículo científico publicado en 1998

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels

artículo científico publicado en 1998

Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.

artículo científico publicado en 2006

Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain

artículo científico publicado en 2004

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

artículo científico publicado en 2011

Ligands for expression cloning and isolation of GABA(B) receptors

artículo científico publicado en 2003

Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization.

artículo científico

Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence.

artículo científico publicado en 2007

Molecular pharmacology of somatostatin-receptor subtypes.

artículo científico publicado en 1994

Molecular structure and physiological functions of GABA(B) receptors

artículo científico publicado en 2004

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

artículo científico publicado en 2003

Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.

artículo científico publicado en 2003

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model

artículo científico publicado en 2018

PET imaging of T cells: Target identification and feasibility assessment.

artículo científico publicado en 2018

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.

artículo científico publicado en 2017

Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.

artículo científico

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

artículo científico publicado en 2001

Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats

artículo científico publicado en 2008

Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses

artículo científico publicado en 2003

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.

artículo científico publicado en 2004

Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.

artículo científico publicado en 2009

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.

artículo científico publicado en 2017

Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release.

artículo científico publicado en 2008

Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

artículo científico publicado en 2004

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

artículo científico publicado en 2003

Specific roles of GABA(B(1)) receptor isoforms in cognition.

artículo científico publicado en 2007

Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.

artículo científico publicado en 2017

Structural basis of species-selective antagonist binding to the succinate receptor

artículo científico publicado en 2019

Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

artículo científico publicado en 2019

Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.

artículo científico publicado en 2005

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors

artículo científico publicado en 2007

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists

artículo científico publicado en 2016

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse.

artículo científico publicado en 1991

The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

artículo científico publicado en 1999

The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function

artículo científico publicado en 2005

The mouse homolog to the ras-related yeast gene YPT1 maps on chromosome 11 close to the wobbler (wr) locus

scientific article published on 01 January 1992

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

scientific journal article

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11

artículo científico publicado el 1 de mayo de 1992

Lista de obras de K Kaupmann

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice.

Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit

Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1.

Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, migfbp-2 ⬇️

Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.

Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain.

Differential compartmentalization and distinct functions of GABAB receptor variants

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain

Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.

Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.

Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation

GABAB receptors - the first 7TM heterodimers.

GABAB receptors: drugs meet clones.

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.

Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.

Heteromerization of GABAB Receptors: A New Principle for G Protein-Coupled Receptors. Satellite Symposium to the 28th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5-7, 1998.

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels

Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.

Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

Ligands for expression cloning and isolation of GABA(B) receptors

Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization.

Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence.

Molecular pharmacology of somatostatin-receptor subtypes.

Molecular structure and physiological functions of GABA(B) receptors

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model

PET imaging of T cells: Target identification and feasibility assessment.

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.

Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats

Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.

Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.

Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release.

Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

Specific roles of GABA(B(1)) receptor isoforms in cognition.

Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.

Structural basis of species-selective antagonist binding to the succinate receptor

Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse.

The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function

The mouse homolog to the ras-related yeast gene YPT1 maps on chromosome 11 close to the wobbler (wr) locus

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11