Lista de obras - R González Muñiz - Dominio Público Uruguay

"Dipeptoids": from the chemical structure of the endogenous peptide to the design of peptidomimetics.

artículo científico publicado en 2004

1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties

artículo científico publicado en 2016

1-(2',5'-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity

scientific article published on 02 August 2019

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

artículo científico publicado en 2010

2-Oxopyrrolidines and 6-oxoperhydropyrrolo[1,2-a]pyrazines as templates in the search for nonpeptide cholecystokinin ligands.

artículo científico publicado en 1998

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan Domain

scientific article published on 01 November 1999

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.

artículo científico publicado en 2001

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.

artículo científico publicado en 2001

A role for ring-closing metathesis in medicinal chemistry: mimicking secondary architectures in bioactive peptides.

artículo científico publicado en 2010

Advances in modulating thermosensory TRP channels.

artículo científico

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

artículo científico publicado en 2017

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

artículo científico publicado en 2005

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

artículo científico publicado en 2012

Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists ⬇️

artículo científico publicado el 1 de diciembre de 1990

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities

scientific article published on 25 August 2020

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding

artículo científico publicado en 2014

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

artículo científico publicado en 2005

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

artículo científico publicado en 2005

Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.

artículo científico publicado en 2011

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

artículo científico publicado en 2014

Disrupting VEGF-VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment

artículo científico publicado en 2017

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

article

Disulfide bonds versus TrpTrp pairs in irregular beta-hairpins: NMR structure of vammin loop 3-derived peptides as a case study.

artículo científico publicado en 2009

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

scientific article published on 01 May 2015

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

artículo científico publicado en 2002

Enantioselective synthesis of PPAR (peroxisome proliferator-activated receptors) agonists and antagonists.

artículo científico publicado en 2014

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

artículo científico publicado en 2007

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis

artículo científico publicado en 2014

Exploring solid-phase approaches for the preparation of new beta-lactams from amino acids.

artículo científico publicado en 2003

From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.

artículo científico publicado en 2005

General approach for the stereocontrolled construction of the beta-lactam ring in amino acid-derived 4-alkyl-4-carboxy-2-azetidinones.

artículo científico publicado en 2002

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

artículo científico publicado en 2013

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

artículo científico publicado en 1999

Highly functionalized 1,2-diamino compounds through reductive amination of amino acid-derived β-keto esters

artículo científico publicado en 2013

Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.

artículo científico publicado en 2016

Ketomethylene analogues of phosphoryl dipeptides related to phosphoramidon: synthesis and inhibition of proteases

artículo científico publicado en 1992

Ketomethylene and (Cyanomethylene)amino Pseudopeptide Analogs of the C-Terminal Hexapeptide of Neurotensin

artículo científico publicado en 1995

Ketomethylene and methyleneamino pseudopeptide analogues of insect allatostatins inhibit juvenile hormone and vitellogenin production in the cockroach Blattella germanica.

artículo científico publicado en 1997

Larger Helical Populations in Peptides Derived from the Dimerization Helix of the Capsid Protein of HIV-1 Results in Peptide Binding toward Regions Other than the “Hotspot” Interface ⬇️

artículo científico publicado el 26 de julio de 2011

Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.

artículo científico publicado en 2017

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

artículo científico publicado en 2011

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

artículo científico publicado en 2011

Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.

artículo científico publicado en 2004

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

scientific article published on 18 July 2011

Recent progress in non-opioid analgesic peptides

artículo científico publicado en 2018

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

artículo científico publicado en 2018

SMALL LIBRARY OF TRIAZOLYL POLYPHENOLS CORRELATING ANTIOXIDANT ACTIVITY AND STABILITY WITH NUMBER AND POSITION OF HYDROXYL GROUPS

artículo científico publicado en 2018

Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.

artículo científico publicado en 2010

Strategies for design of non peptide CCK1R agonist/antagonist ligands.

artículo científico publicado en 2007

Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.

artículo científico publicado en 2004

Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues

artículo científico publicado en 2008

Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines

scientific article published on 01 January 1992

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

artículo científico publicado en 1997

Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.

artículo científico publicado en 2017

TRPV1 modulators: structure-activity relationships using a rational combinatorial approach.

artículo científico publicado en 2011

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

artículo científico publicado en 2013

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

artículo científico publicado en 2006

Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer.

artículo científico publicado en 2016

Trp-Trp pairs as β-hairpin stabilisers: Hydrogen-bonded versus non-hydrogen-bonded sites

artículo científico publicado en 2011

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators

article

beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.

artículo científico publicado en 2000

Lista de obras de R González Muñiz

"Dipeptoids": from the chemical structure of the endogenous peptide to the design of peptidomimetics.

1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties

1-(2',5'-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity

2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments

2-Oxopyrrolidines and 6-oxoperhydropyrrolo[1,2-a]pyrazines as templates in the search for nonpeptide cholecystokinin ligands.

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1Receptor Antagonists: Structural Modifications at the Tryptophan Domain

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.

5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.

A role for ring-closing metathesis in medicinal chemistry: mimicking secondary architectures in bioactive peptides.

Advances in modulating thermosensory TRP channels.

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists ⬇️

Characterization of Novel Synthetic Polyphenols: Validation of Antioxidant and Vasculoprotective Activities

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

Conformationally constrained CCK4 analogues incorporating IBTM and BTD beta-turn mimetics.

Cyclic amino acid linkers stabilizing key loops of brain derived neurotrophic factor.

De novo designed library of linear helical peptides: an exploratory tool in the discovery of protein-protein interaction modulators

Disrupting VEGF-VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

Disulfide bonds versus TrpTrp pairs in irregular beta-hairpins: NMR structure of vammin loop 3-derived peptides as a case study.

Divergent, stereoselective access to heterocyclic α,α-quaternary- and β2,3,3-amino acid derivatives from a N-Pmp-protected Orn-derived β-lactam

Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.

Enantioselective synthesis of PPAR (peroxisome proliferator-activated receptors) agonists and antagonists.

Exceptional Stereoselectivity in the Synthesis of 1,3,4-Trisubstituted 4-Carboxy β-Lactam Derivatives from Amino Acids

Experimental and Theoretical Studies on the Rearrangement of 2-Oxoazepane α,α-Amino Acids into 2′-Oxopiperidine β2,3,3-Amino Acids: An Example of Intramolecular Catalysis

Exploring solid-phase approaches for the preparation of new beta-lactams from amino acids.

From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors.

General approach for the stereocontrolled construction of the beta-lactam ring in amino acid-derived 4-alkyl-4-carboxy-2-azetidinones.

Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.

Highly constrained dipeptoid analogues containing a type II' beta-turn mimic as novel and selective CCK-A receptor ligands.

Highly functionalized 1,2-diamino compounds through reductive amination of amino acid-derived β-keto esters

Identification, functional gastrointestinal stability and molecular docking studies of lentil peptides with dual antioxidant and angiotensin I converting enzyme inhibitory activities.

Ketomethylene analogues of phosphoryl dipeptides related to phosphoramidon: synthesis and inhibition of proteases

Ketomethylene and (Cyanomethylene)amino Pseudopeptide Analogs of the C-Terminal Hexapeptide of Neurotensin

Ketomethylene and methyleneamino pseudopeptide analogues of insect allatostatins inhibit juvenile hormone and vitellogenin production in the cockroach Blattella germanica.

Larger Helical Populations in Peptides Derived from the Dimerization Helix of the Capsid Protein of HIV-1 Results in Peptide Binding toward Regions Other than the “Hotspot” Interface ⬇️

Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.

Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis.

Quaternary α,α-2-Oxoazepane α-Amino Acids: Synthesis from Ornithine-Derived β-Lactams and Incorporation into Model Dipeptides

Recent progress in non-opioid analgesic peptides

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

SMALL LIBRARY OF TRIAZOLYL POLYPHENOLS CORRELATING ANTIOXIDANT ACTIVITY AND STABILITY WITH NUMBER AND POSITION OF HYDROXYL GROUPS

Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.

Strategies for design of non peptide CCK1R agonist/antagonist ligands.

Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine.

Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues

Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines

Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists.

Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists.

TRPV1 modulators: structure-activity relationships using a rational combinatorial approach.

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer.

Trp-Trp pairs as β-hairpin stabilisers: Hydrogen-bonded versus non-hydrogen-bonded sites

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators

beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists.