Lista de obras - D Nemazee - Dominio Público Uruguay

A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro

scientific article published on 01 May 2000

A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors

scientific article published on 01 August 1997

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

artículo científico publicado en 2020

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

scientific article published on April 2005

Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse

artículo científico publicado en 1999

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

scientific article published on 17 November 2020

An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

artículo científico publicado en 2005

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes

scientific article published on 01 July 1996

Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.

artículo científico publicado en 1997

Antigen receptor 'capacity' and the sensitivity of self-tolerance.

artículo científico publicado en 1996

Antigen receptor selection by editing or downregulation of V(D)J recombination.

artículo científico publicado en 2003

Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

artículo científico publicado en 1998

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

artículo científico publicado en 2020

B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.

artículo científico publicado en 2000

B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice

artículo científico publicado en 2004

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

artículo científico publicado en 1996

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

scientific article published on 01 September 2020

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

artículo científico publicado en 2013

B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras

artículo científico publicado en 1991

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

artículo científico publicado en 2007

Broad neutralization of SARS-related viruses by human monoclonal antibodies

artículo científico publicado en 2020

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors

artículo científico publicado en 2021

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

artículo científico publicado en 1989

Contribution of Receptor Editing to the Antibody Repertoire

artículo científico publicado en 2001

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

artículo científico publicado en 2009

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.

artículo científico publicado en 2010

Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.

artículo científico publicado en 2010

DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF

artículo científico publicado en 2003

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

artículo científico publicado en 2017

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes

scientific article published on 25 July 2019

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

artículo científico publicado en 1998

Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.

artículo científico publicado en 1999

Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory

artículo científico publicado en 1995

Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen

artículo científico publicado en 2006

Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes

artículo científico publicado en 1998

Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology.

artículo científico publicado en 2012

Enhancing antibody: a novel component of the immune response.

artículo científico publicado en 1982

FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles

artículo científico publicado en 2008

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

artículo científico publicado en 1994

Generation of T-follicular helper cells in vitro: requirement for BCR cross-linking and cognate B- and T-cell interaction.

artículo científico publicado en 2017

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

artículo científico publicado en 2015

HIV-1 vaccine design through minimizing envelope metastability

article

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

artículo científico publicado en 2016

Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.

artículo científico publicado en 1985

Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity.

artículo científico publicado en 1999

Inability of IL-2 and IL-10 to counteract B cell clonal deletion

artículo científico publicado en 1992

Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response ⬇️

artículo científico publicado el 1 de agosto de 1983

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

artículo científico publicado en 2020

Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.

artículo científico publicado en 2011

Mechanisms and meaning of B-lymphocyte tolerance.

artículo científico publicado en 1992

Mechanisms of central tolerance for B cells.

artículo científico publicado en 2017

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape

artículo científico publicado en 2011

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

scientific article published on 13 August 2018

Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.

artículo científico publicado en 2006

Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.

artículo científico publicado en 2010

Peripheral B lymphocyte tolerance.

artículo científico publicado en 2004

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

artículo científico publicado en 2017

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

artículo científico publicado en 2016

Promotion and prevention of autoimmunity by B lymphocytes.

artículo científico publicado en 1993

Rational immunogen design to target specific germline B cell receptors

artículo científico publicado en 2012

Receptor editing and commitment in B lymphocytes ⬇️

artículo científico publicado el 1 de abril de 1998

Receptor editing and genetic variability in human autoreactive B cells.

artículo científico publicado en 2015

Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A

artículo científico publicado en 2004

Receptor editing in lymphocyte development and central tolerance.

artículo científico publicado en 2006

Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.

artículo científico publicado en 2011

Receptor editing occurs frequently during normal B cell development.

artículo científico publicado en 1998

Receptor editing: genetic reprogramming of autoreactive lymphocytes.

artículo científico publicado en 1999

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

scientific article published on 02 August 2016

Regulation of the B cell receptor repertoire and self-reactivity by BAFF

artículo científico publicado en 2010

Role of RS/kappaDE in B cell receptor editing.

artículo científico publicado en 2007

Role of receptor editing and revision in shaping the B and T lymphocyte repertoire.

artículo científico publicado en 2001

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

artículo científico publicado en 1997

Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

artículo científico publicado en 2012

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

scientific article published on 06 August 2020

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

artículo científico publicado en 2020

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

artículo científico publicado en 2020

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

artículo científico publicado en 2016

Targeting cytotoxic T cells to antigen-specific B lymphocytes

artículo científico publicado en 1987

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.

artículo científico publicado en 2017

The design and implementation of the immune epitope database and analysis resource

artículo científico publicado en 2005

The immune epitope database and analysis resource: from vision to blueprint

artículo científico publicado en 2005

The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

artículo científico publicado en 2016

Theoretical limits to massive receptor editing in immature B cells.

artículo científico publicado en 1998

Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.

artículo científico publicado en 2004

Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice

artículo científico publicado en 2000

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

artículo científico publicado en 1997

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

scientific article published on 17 November 2020

Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization.

artículo científico publicado en 1987

Lista de obras de D Nemazee

A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro

A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes

Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.

Antigen receptor 'capacity' and the sensitivity of self-tolerance.

Antigen receptor selection by editing or downregulation of V(D)J recombination.

Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.

B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

Contribution of Receptor Editing to the Antibody Repertoire

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.

Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.

DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.

Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory

Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen

Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes

Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology.

Enhancing antibody: a novel component of the immune response.

FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

Generation of T-follicular helper cells in vitro: requirement for BCR cross-linking and cognate B- and T-cell interaction.

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

HIV-1 vaccine design through minimizing envelope metastability

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.

Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity.

Inability of IL-2 and IL-10 to counteract B cell clonal deletion

Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response ⬇️

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.

Mechanisms and meaning of B-lymphocyte tolerance.

Mechanisms of central tolerance for B cells.

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.

Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.

Peripheral B lymphocyte tolerance.

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

Promotion and prevention of autoimmunity by B lymphocytes.

Rational immunogen design to target specific germline B cell receptors

Receptor editing and commitment in B lymphocytes ⬇️

Receptor editing and genetic variability in human autoreactive B cells.

Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A

Receptor editing in lymphocyte development and central tolerance.

Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.

Receptor editing occurs frequently during normal B cell development.

Receptor editing: genetic reprogramming of autoreactive lymphocytes.

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

Regulation of the B cell receptor repertoire and self-reactivity by BAFF

Role of RS/kappaDE in B cell receptor editing.

Role of receptor editing and revision in shaping the B and T lymphocyte repertoire.

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

Targeting cytotoxic T cells to antigen-specific B lymphocytes

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.