Lista de obras -

A consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interaction

artículo científico publicado en 2003

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

artículo científico publicado en 2016

A structural basis for the unique binding features of the human vitamin D-binding protein

artículo científico publicado en 2002

An alternate sucrose binding mode in the E203Q Arabidopsis invertase mutant: an X-ray crystallography and docking study

artículo científico publicado en 2008

An unusual red-edge excitation and time-dependent Stokes shift in the single tryptophan mutant protein DD-carboxypeptidase from Streptomyces: the role of dynamics and tryptophan rotamers

artículo científico publicado en 2007

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

artículo científico publicado en 2002

Biochemical and structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor

artículo científico publicado en 2009

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

artículo científico publicado en 2012

Combined Modeling and Biophysical Characterisation of CO2 Interaction with Class II Hydrophobins: New Insight into the Mechanism Underpinning Primary Gushing

Combined molecular and supramolecular bottom-up nanoengineering for enhanced nonlinear optical response: experiments, modeling, and approaching the fundamental limit

artículo científico publicado en 2007

Computational Studies of the Active and Inactive Regulatory Domains of Response Regulator PhoP Using Molecular Dynamics Simulations

artículo científico publicado en 2017

Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

artículo científico publicado en 2003

Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor

artículo científico publicado en 2012

Experimental indication for the existence of multiple Trp rotamers in von Willebrand Factor A3 domain

artículo científico publicado en 2004

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

artículo científico publicado en 2012

Five lung nodules, four different pathologic findings: not all lung lesions are the same

artículo científico publicado en 2016

Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2, lipoxygenase, thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway

artículo científico publicado en 2009

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort

artículo científico publicado en 2014

How do rotameric conformations influence the time-resolved fluorescence of tryptophan in proteins? A perspective based on molecular modeling and quantum chemistry

artículo científico publicado en 2008

Identification of the LEDGF/p75 binding site in HIV-1 integrase

artículo científico publicado en 2007

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation

artículo científico publicado en 2008

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer

scientific article published on October 2009

In vivo neutralization of a C2 domain-specific human anti-Factor VIII inhibitor by an anti-idiotypic antibody

artículo científico publicado en 2003

Influence of limited proteolysis, detergent treatment and lyophilization on the phenoloxidase activity of Rapana thomasiana hemocyanin.

artículo científico publicado en 2009

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

artículo científico publicado en 2011

Kinases as targets for Parkinson's disease: from genetics to therapy

artículo científico publicado en 2011

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

artículo científico

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

artículo científico publicado en 2011

Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev

artículo científico publicado en 2013

Mechanism of Nonpolar Model Substances to Inhibit Primary Gushing Induced by Hydrophobin HFBI.

artículo científico publicado en 2015

Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.

artículo científico publicado en 2004

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

artículo científico publicado en 2009

Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.

artículo científico publicado en 2008

Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain

artículo científico publicado en 2005

Protein simulations: the absorption spectrum of barnase point mutants

artículo científico publicado en 2004

Rational design of small molecules that modulate the transcriptional function of the response regulator PhoP.

artículo científico publicado en 2017

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

artículo científico publicado en 2010

Staphylokinase-Specific Cell-Mediated Immunity in Humans ⬇️

artículo científico publicado el 1 de enero de 2002

Structure based discovery of small molecule suppressors targeting bacterial lysozyme inhibitors

artículo científico publicado en 2011

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).

artículo científico publicado en 2017

Study of recombinant antibody fragments and PAI-1 complexes combining protein-protein docking and results from site-directed mutagenesis

artículo científico publicado en 2007

The dead-end elimination method, tryptophan rotamers, and fluorescence lifetimes

artículo científico publicado en 2003

The dead-end elimination theorem and its use in protein side-chain positioning ⬇️

artículo científico publicado el 9 de abril de 1992

Tryptophan conformations associated with partial unfolding in ribonuclease T1

artículo científico publicado en 2009

Tryptophan rotamers as evidenced by X-ray, fluorescence lifetimes, and molecular dynamics modeling

artículo científico publicado en 2006

Tuning the Size and Properties of ClyA Nanopores Assisted by Directed Evolution ⬇️

artículo científico publicado el 27 de agosto de 2013

Understanding the role of defective invertases in plants: tobacco Nin88 fails to degrade sucrose

artículo científico publicado en 2013

Validation of APRI and FIB-4 score in an Antwerp cohort of chronic hepatitis C patients

artículo científico publicado en 2015

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

artículo científico publicado en 2007

pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?

artículo científico publicado en 2012

Lista de obras de

A consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interaction

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

A structural basis for the unique binding features of the human vitamin D-binding protein

An alternate sucrose binding mode in the E203Q Arabidopsis invertase mutant: an X-ray crystallography and docking study

An unusual red-edge excitation and time-dependent Stokes shift in the single tryptophan mutant protein DD-carboxypeptidase from Streptomyces: the role of dynamics and tryptophan rotamers

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

Biochemical and structural characterization of TLXI, the Triticum aestivum L. thaumatin-like xylanase inhibitor

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Combined Modeling and Biophysical Characterisation of CO2 Interaction with Class II Hydrophobins: New Insight into the Mechanism Underpinning Primary Gushing

Combined molecular and supramolecular bottom-up nanoengineering for enhanced nonlinear optical response: experiments, modeling, and approaching the fundamental limit

Computational Studies of the Active and Inactive Regulatory Domains of Response Regulator PhoP Using Molecular Dynamics Simulations

Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor

Experimental indication for the existence of multiple Trp rotamers in von Willebrand Factor A3 domain

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

Five lung nodules, four different pathologic findings: not all lung lesions are the same

Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2, lipoxygenase, thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort

How do rotameric conformations influence the time-resolved fluorescence of tryptophan in proteins? A perspective based on molecular modeling and quantum chemistry

Identification of the LEDGF/p75 binding site in HIV-1 integrase

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer

In vivo neutralization of a C2 domain-specific human anti-Factor VIII inhibitor by an anti-idiotypic antibody

Influence of limited proteolysis, detergent treatment and lyophilization on the phenoloxidase activity of Rapana thomasiana hemocyanin.

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Kinases as targets for Parkinson's disease: from genetics to therapy

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev

Mechanism of Nonpolar Model Substances to Inhibit Primary Gushing Induced by Hydrophobin HFBI.

Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.

Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain

Protein simulations: the absorption spectrum of barnase point mutants

Rational design of small molecules that modulate the transcriptional function of the response regulator PhoP.

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Staphylokinase-Specific Cell-Mediated Immunity in Humans ⬇️

Structure based discovery of small molecule suppressors targeting bacterial lysozyme inhibitors

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).

Study of recombinant antibody fragments and PAI-1 complexes combining protein-protein docking and results from site-directed mutagenesis

The dead-end elimination method, tryptophan rotamers, and fluorescence lifetimes

The dead-end elimination theorem and its use in protein side-chain positioning ⬇️

Tryptophan conformations associated with partial unfolding in ribonuclease T1

Tryptophan rotamers as evidenced by X-ray, fluorescence lifetimes, and molecular dynamics modeling

Tuning the Size and Properties of ClyA Nanopores Assisted by Directed Evolution ⬇️

Understanding the role of defective invertases in plants: tobacco Nin88 fails to degrade sucrose

Validation of APRI and FIB-4 score in an Antwerp cohort of chronic hepatitis C patients

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?