Lista de obras - D R Gill - Dominio Público Uruguay

A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial

artículo científico publicado en 2015

A novel mixing device for the reproducible generation of nonviral gene therapy formulations.

artículo científico publicado en 2010

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.

artículo científico publicado en 1997

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

artículo científico publicado en 2016

A second dose of a CFTR cDNA–liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea ⬇️

artículo científico publicado el 1 de noviembre de 1997

Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.

artículo científico publicado en 2014

An immunocytochemical assay to detect human CFTR expression following gene transfer

artículo científico publicado en 2009

Assessment of CFTR function after gene transfer in vitro and in vivo.

artículo científico publicado en 2008

Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy

artículo científico publicado en 2012

Assessment of selected media supplements to improve F/HN lentiviral vector production yields.

artículo científico publicado en 2017

Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.

artículo científico publicado en 1997

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

artículo científico publicado en 1993

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy ⬇️

artículo científico publicado el 22 de junio de 2012

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

artículo científico publicado en 2008

Delivery of genes into the CF airway.

artículo científico

Detection of plasmid DNA vectors following gene transfer to the murine airways.

artículo científico publicado en 2005

Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.

artículo científico publicado en 1994

Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles.

artículo científico publicado en 2014

Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure.

artículo científico publicado en 2015

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.

artículo científico publicado en 2005

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.

artículo científico publicado en 2007

Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts

scientific article published on 01 February 2006

Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes

article

Genetic medicines for CF: Hype versus reality

artículo científico publicado en 2016

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

artículo científico publicado en 2016

Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways

artículo científico

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids

artículo científico publicado en 2020

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.

artículo científico publicado en 2015

Identification of transfected cell types following non-viral gene transfer to the murine lung.

artículo científico publicado en 2007

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

artículo científico publicado en 2001

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

artículo científico publicado en 2006

Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.

artículo científico

Lessons learned from lung and liver in-vivo gene therapy: implications for the future

article

Limitations of the murine nose in the development of nonviral airway gene transfer.

artículo científico

Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of hu

artículo científico publicado en 1992

Lung-targeting lentiviral vector for passive immunisation against influenza

scientific article published on 03 September 2020

Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

artículo científico publicado en 2018

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.

artículo científico publicado en 2002

Optimizing aerosol gene delivery and expression in the ovine lung

artículo científico

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

artículo científico

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.

artículo científico publicado en 2016

Progress and prospects: the design and production of plasmid vectors.

artículo científico publicado en 2009

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

scientific journal article

Rapid identification of novel functional promoters for gene therapy.

artículo científico publicado en 2012

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

artículo científico publicado en 2015

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.

artículo científico publicado en 2011

Self-reactive CFTR T cells in humans: implications for gene therapy.

scientific article published on 19 July 2013

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

artículo científico publicado en 1992

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

artículo científico publicado en 1993

Strategies for long-term expression of transgenes in the respiratory epithelium.

artículo científico publicado en 2010

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

artículo científico publicado en 1994

The identification of the Escherichia coli ftsY gene product: an unusual protein.

artículo científico publicado en 1990

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

artículo científico publicado en 2018

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.

artículo científico publicado en 2013

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.

artículo científico publicado en 2012

Towards gene therapy for cystic fibrosis: a clinical progress report.

artículo científico publicado en 1998

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung

artículo científico publicado en 2013

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid–DNA complexes to ovine lung segments ⬇️

artículo científico publicado el 1 de octubre de 2003

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

artículo científico publicado en 2016

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

artículo científico publicado en 1992

Lista de obras de D R Gill

A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial

A novel mixing device for the reproducible generation of nonviral gene therapy formulations.

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

A second dose of a CFTR cDNA–liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea ⬇️

Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.

An immunocytochemical assay to detect human CFTR expression following gene transfer

Assessment of CFTR function after gene transfer in vitro and in vivo.

Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy

Assessment of selected media supplements to improve F/HN lentiviral vector production yields.

Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

CpG-free plasmid expression cassettes for cystic fibrosis gene therapy ⬇️

CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.

Delivery of genes into the CF airway.

Detection of plasmid DNA vectors following gene transfer to the murine airways.

Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.

Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles.

Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure.

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.

Electroporation enhances reporter gene expression following delivery of naked plasmid DNA to the lung.

Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts

Enhanced Lung Gene Expression After Aerosol Delivery of Concentrated pDNA/PEI Complexes

Genetic medicines for CF: Hype versus reality

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways

Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.

Identification of transfected cell types following non-viral gene transfer to the murine lung.

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.

Lessons learned from lung and liver in-vivo gene therapy: implications for the future

Limitations of the murine nose in the development of nonviral airway gene transfer.

Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of hu

Lung-targeting lentiviral vector for passive immunisation against influenza

Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.

Optimizing aerosol gene delivery and expression in the ovine lung

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.

Progress and prospects: the design and production of plasmid vectors.

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels

Rapid identification of novel functional promoters for gene therapy.

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.

Self-reactive CFTR T cells in humans: implications for gene therapy.

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

Strategies for long-term expression of transgenes in the respiratory epithelium.

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

The identification of the Escherichia coli ftsY gene product: an unusual protein.

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.

The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.

Towards gene therapy for cystic fibrosis: a clinical progress report.

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung

Transfection efficiency and toxicity following delivery of naked plasmid DNA and cationic lipid–DNA complexes to ovine lung segments ⬇️

Transgene sequences free of CG dinucleotides lead to high level, long-term expression in the lung independent of plasmid backbone design

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein