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Lista de obras de R.H. Porter

ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology

scientific article published on 01 January 1996

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application

artículo científico publicado en 2005

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

artículo científico publicado en 2008

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

artículo científico publicado en 2006

Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion.

artículo científico publicado en 1995

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

artículo científico publicado en 2006

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors

artículo científico publicado en 2005

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series

artículo científico publicado en 2009

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

artículo científico publicado en 2005

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

artículo científico publicado en 2011

GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation

artículo científico publicado en 2000

Glutamate and Parkinson's disease

artículo científico publicado en 1996

Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist

artículo científico publicado en 2003

Inhibition of autoradiographic MK-801 binding by an endogenous factor.

artículo científico publicado en 1994

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

artículo científico publicado en 1993

Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series

artículo científico publicado en 2008

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine ⬇️

artículo científico publicado el 1 de octubre de 2003

NMDA and AMPA receptors in transgenic mice expressing human beta-amyloid protein.

artículo científico publicado en 1993

Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion.

artículo científico publicado en 1994

Regional variations in the pharmacology of AMPA receptors as revealed by receptor autoradiography

scientific article published on 01 November 1994

Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential

scientific article published on 01 February 1995

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease ⬇️

artículo científico publicado el 2 de julio de 2011

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