Lista de obras - Grimm D - Dominio Público Uruguay

A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses

scientific article published on 08 January 2019

A chemical switch for controlling viral infectivity

artículo científico publicado en 2014

A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8.

artículo científico publicado en 2007

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting

artículo científico publicado en 2021

AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites

artículo científico publicado en 2014

AAVvector-mediated in vivo reprogramming into pluripotency

artículo científico publicado en 2018

Adeno-associated virus vectors for short hairpin RNA expression

artículo científico publicado en 2005

All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution

artículo científico publicado en 2012

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

artículo científico publicado en 2015

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

artículo científico publicado en 2010

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

artículo científico publicado en 2016

Boosters for adeno-associated virus (AAV) vector (r)evolution

scientific article published in 2022

Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders

scientific article published on 15 October 2020

CRISPR genome engineering and viral gene delivery: a case of mutual attraction

artículo científico

CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox

artículo científico publicado en 2014

Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins

scientific article published on 01 July 2019

Combinatorial RNAi: a winning strategy for the race against evolving targets?

artículo científico publicado en 2007

Computational design of anti-CRISPR proteins with improved inhibition potency

scientific article published on 13 April 2020

Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors

scientific article published on 17 October 2019

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution

artículo científico publicado en 2015

Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9

Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

scholarly article by Felix Bubeck published in October 2018

Engineering and evolution of synthetic adeno-associated virus (AAV) gene therapy vectors via DNA family shuffling.

artículo científico publicado en 2012

Everybody wins! Poland hosts thrilling competitions of viruses, RNAi and football teams

artículo científico publicado en 2012

Expression determinants of mammalian argonaute proteins in mediating gene silencing

artículo científico publicado en 2011

Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic

artículo científico publicado en 2008

Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

artículo científico publicado en 2019

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

artículo científico publicado en 2022

Fantastic AAV Gene Therapy Vectors and How to Find Them—Random Diversification, Rational Design and Machine Learning

artículo científico publicado en 2022

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

artículo científico publicado en 2006

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

artículo científico publicado en 2011

Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors

scientific article (publication date: 2014)

Gene knockdown in malaria parasites via non-canonical RNAi

artículo científico publicado en 2020

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites

artículo científico publicado en 2016

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6.

artículo científico publicado en 2003

Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells

artículo científico publicado en 2008

High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone

artículo científico publicado en 2021

High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.

artículo científico publicado en 2018

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

artículo científico publicado en 2020

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

artículo científico publicado en 2018

Impact of natural or synthetic singletons in the capsid of human bocavirus 1 on particle infectivity and immunoreactivity

scientific article published on 25 March 2020

Impact of the assembly-activating protein (AAP) on molecular evolution of synthetic Adeno-associated virus (AAV) capsids

artículo científico publicado en 2018

Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors

artículo científico publicado en 2006

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses

artículo científico publicado en 2008

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

artículo científico publicado en 2005

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

artículo científico publicado en 2016

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

artículo científico publicado en 2020

Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements

artículo científico publicado en 2020

Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype

artículo científico publicado en 2006

Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice

artículo científico publicado en 2009

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.

artículo científico publicado en 2018

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

artículo científico publicado en 2013

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

artículo científico publicado en 2022

Molecular dissection of human Argonaute proteins by DNA shuffling.

artículo científico publicado en 2013

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

scientific article published on 16 September 2019

Next-generation AAV vectors for clinical use: an ever-accelerating race

artículo científico publicado en 2017

Next-generation AAV vectors-do not judge a virus (only) by its cover

scientific article published on 01 October 2019

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

article

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

scientific article published on 16 December 2020

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

artículo científico publicado en 2017

Plasmodium meets AAV-the (un)likely marriage of parasitology and virology, and how to make the match

artículo científico publicado en 2016

Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening

artículo científico publicado en 2020

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

artículo científico publicado en 2003

Primary human cells differ in their susceptibility to rAAV-2-mediated gene transfer and duration of reporter gene expression

artículo científico publicado en 2002

Production methods for gene transfer vectors based on adeno-associated virus serotypes

artículo científico publicado en 2002

Production, Processing and Characterization of synthetic AAV Gene Therapy Vectors

scientific article published on 25 September 2020

Publisher Correction: Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

scientific article published on 01 February 2019

RNAi and gene therapy: a mutual attraction

artículo científico publicado en 2007

Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors

scientific article published on 01 January 2019

Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium

artículo científico publicado en 2007

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells

artículo científico publicado en 2016

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

artículo científico publicado en 2017

Relevance of assembly-activating protein for Adeno-associated virus vector production and capsid protein stability in mammalian and insect cells

artículo científico publicado en 2017

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

artículo científico publicado en 2013

SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMP

artículo científico publicado en 2020

Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

scientific article published on 01 September 2019

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia

artículo científico publicado en 2008

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

artículo científico publicado en 2017

Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems

artículo científico publicado en 2010

Small but increasingly mighty - Latest advances in AAV vector research, design and evolution

artículo científico publicado en 2017

Small silencing RNAs: state-of-the-art

artículo científico publicado en 2009

Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

artículo científico publicado en 2017

Split Cas9, not hairs - advancing the therapeutic index of CRISPR technology

artículo científico publicado en 2018

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes

artículo científico publicado en 2017

T160‐phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes

artículo científico publicado en 2015

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus

artículo científico publicado en 2016

The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9

artículo científico publicado en 2006

The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression ⬇️

artículo científico publicado el 26 de octubre de 2011

Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

artículo científico publicado en 2007

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes ⬇️

artículo científico publicado el 16 de mayo de 2011

To go, or not to go, that is the question - six personal reflections on how geographic mobility may affect your career and life

artículo científico publicado en 2011

Type I Interferon Regulates the Expression of Long Non-Coding RNAs

artículo científico publicado en 2014

Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut.

artículo científico publicado en 2017

When cellular networks run out of control: global dysregulation of the RNAi machinery in human pathology and therapy

artículo científico publicado en 2011

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

artículo científico publicado en 2015

Lista de obras de Grimm D

A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses

A chemical switch for controlling viral infectivity

A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8.

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting

AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites

AAVvector-mediated in vivo reprogramming into pluripotency

Adeno-associated virus vectors for short hairpin RNA expression

All for one, one for all: new combinatorial RNAi therapies combat hepatitis C virus evolution

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.

Boosters for adeno-associated virus (AAV) vector (r)evolution

Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders

CRISPR genome engineering and viral gene delivery: a case of mutual attraction

CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox

Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins

Combinatorial RNAi: a winning strategy for the race against evolving targets?

Computational design of anti-CRISPR proteins with improved inhibition potency

Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution

Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9

Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

Engineering and evolution of synthetic adeno-associated virus (AAV) gene therapy vectors via DNA family shuffling.

Everybody wins! Poland hosts thrilling competitions of viruses, RNAi and football teams

Expression determinants of mammalian argonaute proteins in mediating gene silencing

Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic

Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

Fantastic AAV Gene Therapy Vectors and How to Find Them—Random Diversification, Rational Design and Machine Learning

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

Gene delivery to adipose tissue using transcriptionally targeted rAAV8 vectors

Gene knockdown in malaria parasites via non-canonical RNAi

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites

Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6.

Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells

High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone

High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

Impact of natural or synthetic singletons in the capsid of human bocavirus 1 on particle infectivity and immunoreactivity

Impact of the assembly-activating protein (AAP) on molecular evolution of synthetic Adeno-associated virus (AAV) capsids

Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors

In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses

Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo.

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements

Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype

Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.

Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

Molecular dissection of human Argonaute proteins by DNA shuffling.

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

Next-generation AAV vectors for clinical use: an ever-accelerating race

Next-generation AAV vectors-do not judge a virus (only) by its cover

Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

Plasmodium meets AAV-the (un)likely marriage of parasitology and virology, and how to make the match

Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

Primary human cells differ in their susceptibility to rAAV-2-mediated gene transfer and duration of reporter gene expression

Production methods for gene transfer vectors based on adeno-associated virus serotypes

Production, Processing and Characterization of synthetic AAV Gene Therapy Vectors

Publisher Correction: Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

RNAi and gene therapy: a mutual attraction

Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors

Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

Relevance of assembly-activating protein for Adeno-associated virus vector production and capsid protein stability in mammalian and insect cells

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMP

Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems