Lista de obras - Lino Tessarollo - Dominio Público Uruguay

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

artículo científico publicado en 2009

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

artículo científico publicado en 2006

A new gain-of-function mouse line to study the role of Wnt3a in development and disease.

artículo científico publicado en 2016

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

artículo científico publicado en 2009

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

artículo científico publicado en 2013

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

artículo científico publicado en 2018

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

scientific article published on 01 April 2020

Ablation of TrkA function in the immune system causes B cell abnormalities

scientific journal article

An inducible and reversible mouse genetic rescue system

artículo científico publicado en 2008

Assaying Homodimers of NF-κB in Live Single Cells

artículo científico publicado en 2019

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation

artículo científico publicado en 2015

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

artículo científico publicado en 2008

BRCA2 deficiency in mice leads to meiotic impairment and infertility

scientific journal article

BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation

artículo científico publicado en 2016

Bcl11a is essential for normal lymphoid development ⬇️

artículo científico publicado el 28 de abril de 2003

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

artículo científico publicado en 2002

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

artículo científico publicado en 2017

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

scientific journal article

Cdk2 catalytic activity is essential for meiotic cell division in vivo

artículo científico publicado en 2016

Cdk2 knockout mice are viable

artículo científico publicado en 2003

Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.

artículo científico publicado en 2004

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1

artículo científico publicado en 2012

Chronic centrosome amplification without tumorigenesis

artículo científico publicado en 2015

Control of hyperphagia prevents obesity in BDNF heterozygous mice

artículo científico publicado en 2004

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages ⬇️

artículo científico publicado el 8 de abril de 2013

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.

artículo científico publicado en 2012

Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous

scientific article published on 23 December 2020

Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2012

Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice

scientific article published on 24 March 2018

Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

artículo científico publicado en 2014

Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication

artículo científico publicado en 2017

Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

artículo científico publicado en 2019

Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes

artículo científico publicado en 2011

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

artículo científico publicado en 2011

Emi2 Is Essential for Mouse Spermatogenesis.

artículo científico publicado en 2017

Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo

artículo científico publicado en 2009

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

artículo científico publicado en 2017

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116 ⬇️

artículo científico publicado el 16 de mayo de 2013

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells

artículo científico publicado en 2008

Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas

artículo científico publicado en 2012

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).

artículo científico publicado en 2015

Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo

artículo científico publicado en 2004

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

artículo científico publicado en 2016

Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development.

artículo científico publicado en 2015

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

artículo científico publicado en 2015

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.

artículo científico publicado en 2012

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier ⬇️

artículo científico publicado el 18 de marzo de 2011

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

artículo científico publicado en 2016

Gene targeting in mouse embryonic stem cells

artículo científico publicado en 2009

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

artículo científico publicado en 2006

Generation of Functional Mouse Hippocampal Neurons

artículo científico publicado en 2020

Genetic deletion of trkB.T1 increases neuromuscular function

artículo científico publicado en 2011

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

artículo científico publicado en 2008

Genomic instability in mice lacking histone H2AX

scientific journal article

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

artículo científico publicado en 2004

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene ⬇️

artículo científico publicado el 1 de septiembre de 2003

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

artículo científico publicado en 2015

Host-derived tumor endothelial marker 8 promotes the growth of melanoma

artículo científico publicado en 2009

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

artículo científico publicado en 2014

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

artículo científico publicado en 2018

Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability.

artículo científico publicado en 2016

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice

artículo científico publicado en 2005

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

artículo científico publicado en 2016

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

scientific journal article

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

artículo científico publicado en 2019

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

artículo científico publicado en 2014

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.

artículo científico publicado en 2008

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

artículo científico publicado en 2014

Manipulating mouse embryonic stem cells

artículo científico publicado en 2009

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

scientific journal article

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

artículo científico publicado en 2012

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

artículo científico publicado en 2002

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

scientific journal article

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

artículo científico publicado en 2007

Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells

artículo científico publicado en 2012

Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice

artículo científico publicado en 2001

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

artículo científico publicado en 2017

NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea

scientific journal article

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli

artículo científico publicado en 2016

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

scientific journal article

Normal viability of Kai1/Cd82 deficient mice ⬇️

artículo científico publicado el 8 de febrero de 2013

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

scientific article published on 23 April 2020

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

article

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression

artículo científico publicado en 2018

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

artículo científico publicado en 2015

Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence

scientific article published on 02 December 2020

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

scientific journal article

RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells.

artículo científico publicado en 2016

RanBPM is essential for mouse spermatogenesis and oogenesis

artículo científico publicado en 2011

RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.

artículo científico publicado en 2010

Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

scientific article published on 20 August 2019

Regulation of Kit Expression in Early Mouse Embryos and ES Cells

artículo científico publicado en 2019

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

artículo científico publicado en 2015

SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis

artículo científico publicado en 2021

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium

artículo científico publicado en 2003

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

artículo científico publicado en 2016

Sexually Dimorphic BDNF Signaling Directs Sensory Innervation of the Mammary Gland ⬇️

artículo científico publicado el 7 de diciembre de 2012

Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression

artículo científico publicado en 2001

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

artículo científico publicado en 2016

Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice

artículo científico publicado en 2012

Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis

scientific article published on 01 November 2019

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

artículo científico publicado en 2002

Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity

artículo científico publicado en 2012

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

artículo científico publicado en 2008

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

artículo científico publicado en 2004

The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok

scientific article published on 09 January 2019

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development

scientific journal article

The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development

artículo científico publicado en 2012

The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo

artículo científico publicado en 2006

The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells

artículo científico publicado en 2008

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

artículo científico publicado en 2012

TrkA in vivo function is negatively regulated by ubiquitination

artículo científico publicado en 2014

TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior

artículo científico publicado en 2022

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

artículo científico publicado en 2012

Lista de obras de Lino Tessarollo

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

A new gain-of-function mouse line to study the role of Wnt3a in development and disease.

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

Ablation of TrkA function in the immune system causes B cell abnormalities

An inducible and reversible mouse genetic rescue system

Assaying Homodimers of NF-κB in Live Single Cells

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

BRCA2 deficiency in mice leads to meiotic impairment and infertility

BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation

Bcl11a is essential for normal lymphoid development ⬇️

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

Cdk2 catalytic activity is essential for meiotic cell division in vivo

Cdk2 knockout mice are viable

Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1

Chronic centrosome amplification without tumorigenesis

Control of hyperphagia prevents obesity in BDNF heterozygous mice

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages ⬇️

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.

Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous

Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis

Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice

Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication

Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

Emi2 Is Essential for Mouse Spermatogenesis.

Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116 ⬇️

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells

Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).

Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development.

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier ⬇️

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Gene targeting in mouse embryonic stem cells

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

Generation of Functional Mouse Hippocampal Neurons

Genetic deletion of trkB.T1 increases neuromuscular function

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

Genomic instability in mice lacking histone H2AX

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene ⬇️

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

Host-derived tumor endothelial marker 8 promotes the growth of melanoma

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability.

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

Manipulating mouse embryonic stem cells

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells

Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli