Lista de obras - Karin M. Danzer - Dominio Público Uruguay

ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

artículo científico publicado en 2016

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

artículo científico publicado en 2011

Age Increases Monocyte Adhesion on Collagen.

artículo científico publicado en 2017

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

artículo científico publicado en 2015

Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis.

artículo científico publicado en 2016

Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry

artículo científico publicado en 2011

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

artículo científico publicado en 2009

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency

artículo científico publicado en 2018

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

artículo científico publicado en 2014

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization

artículo científico publicado en 2016

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

artículo científico publicado en 2007

Drug targets from genetics: α-synuclein

artículo científico

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS

artículo científico publicado en 2018

Enhanced hyaluronan signaling and autophagy dysfunction by VPS35 D620N

artículo científico publicado en 2020

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

artículo científico publicado en 2012

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

artículo científico publicado en 2015

Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers

artículo científico publicado en 2007

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro ⬇️

artículo científico publicado el 21 de julio de 2011

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice

artículo científico publicado en 2020

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

artículo científico publicado en 2015

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity ⬇️

artículo científico publicado el 27 de septiembre de 2010

Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice

artículo científico publicado en 2020

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

scientific article published on 11 January 2019

Hot-spot KIF5A mutations cause familial ALS

Impaired activation of ALS monocytes by exosomes

artículo científico publicado en 2016

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

artículo científico publicado en 2019

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies

artículo científico publicado en 2015

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

artículo científico publicado en 2014

Intracellular Alpha-Synuclein and Immune Cell Function

scientific article published on 15 October 2020

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species

artículo científico publicado en 2019

LRRK2 contributes to monocyte dysregulation in Parkinson's disease

artículo científico publicado en 2016

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model

scientific article published on 30 August 2019

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

artículo científico publicado en 2014

NEK1 mutations in familial amyotrophic lateral sclerosis

artículo científico publicado en 2016

PGC-1 is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis ⬇️

artículo científico publicado el 12 de mayo de 2013

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

artículo científico publicado en 2016

Proteasome impairment by α-synuclein.

artículo científico publicado en 2017

Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins

artículo científico publicado en 2008

Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition

artículo científico publicado en 2007

Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA

artículo científico publicado en 2020

Release and uptake of pathologic alpha-synuclein

artículo científico publicado en 2018

Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations

artículo científico publicado en 2019

SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden

artículo científico publicado en 2019

Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant

artículo científico publicado en 2015

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

artículo científico publicado en 2009

Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers

artículo científico publicado en 2014

Serum microRNAs in sporadic amyotrophic lateral sclerosis.

artículo científico publicado en 2015

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

artículo científico publicado en 2008

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

artículo científico publicado en 2014

TDP-43 is intercellularly transmitted across axon terminals

artículo científico publicado en 2015

Telomere shortening leads to earlier age of onset in ALS mice

artículo científico publicado en 2016

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

artículo científico publicado en 2015

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion

artículo científico

The Role of Lipids in the Initiation of α-Synuclein Misfolding

artículo científico publicado en 2020

Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease

artículo científico publicado en 2014

α-Synuclein in Parkinson's disease: pathogenic function and translation into animal models

artículo científico

α-synuclein interacts with SOD1 and promotes its oligomerization

artículo científico publicado en 2015

Lista de obras de Karin M. Danzer

ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

Age Increases Monocyte Adhesion on Collagen.

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis.

Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

Drug targets from genetics: α-synuclein

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS

Enhanced hyaluronan signaling and autophagy dysfunction by VPS35 D620N

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro ⬇️

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity ⬇️

Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

Hot-spot KIF5A mutations cause familial ALS

Impaired activation of ALS monocytes by exosomes

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

Intracellular Alpha-Synuclein and Immune Cell Function

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species

LRRK2 contributes to monocyte dysregulation in Parkinson's disease

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

NEK1 mutations in familial amyotrophic lateral sclerosis

PGC-1 is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis ⬇️

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

Proteasome impairment by α-synuclein.

Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins

Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition

Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA

Release and uptake of pathologic alpha-synuclein

Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations

SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden

Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers

Serum microRNAs in sporadic amyotrophic lateral sclerosis.

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

TDP-43 is intercellularly transmitted across axon terminals

Telomere shortening leads to earlier age of onset in ALS mice

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion

The Role of Lipids in the Initiation of α-Synuclein Misfolding

Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease

α-Synuclein in Parkinson's disease: pathogenic function and translation into animal models

α-synuclein interacts with SOD1 and promotes its oligomerization