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Lista de obras de Richard Neubig

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

scientific article published on 18 April 2019

A Two-Pulse Cellular Stimulation Test Elucidates Variability and Mechanisms in Signaling Pathways

artículo científico publicado en 2019

A central role for R7bp in the regulation of itch sensation

artículo científico publicado en 2017

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

artículo científico publicado en 2009

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

artículo científico publicado en 2009

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

artículo científico publicado en 2008

A mechanistic review on GNAO1-associated movement disorder

scientific article published on 24 May 2018

A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins

artículo científico publicado en 2011

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

artículo científico publicado en 2011

A point mutation in Galphao and Galphai1 blocks interaction with regulator of G protein signaling proteins

artículo científico publicado en 1998

A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.

artículo científico publicado en 2002

A threshold level of coupled G-proteins is required to transduce neutrophil responses

artículo científico publicado en 1992

ANG II type 1 receptor downregulation does not require receptor endocytosis or G protein coupling

artículo científico publicado en 2001

AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.

artículo científico publicado en 2002

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides ⬇️

artículo científico publicado el 1 de febrero de 1979

Affinity assays using fluorescence anisotropy with capillary electrophoresis separation

artículo científico publicado en 2004

Agonist and antagonist binding to alpha 2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry

artículo científico publicado en 1985

Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s)

artículo científico publicado en 2000

Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986

scientific journal article

An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency for Regulators of G-protein Signaling Proteins 4, 8, and 19

artículo científico publicado en 2019

Analysis of guanine nucleotide binding and exchange kinetics of the Escherichia coli GTPase Era.

artículo científico publicado en 2000

Analyzing binding data

artículo científico publicado en 2010

Analyzing radioligand binding data

scientific article published on 01 May 2001

Analyzing radioligand binding data.

artículo científico publicado en 2002

And the winner is ... RGS4!

artículo científico publicado en 2008

Assembly of high order G alpha q-effector complexes with RGS proteins

artículo científico publicado en 2008

Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation

artículo científico publicado en 2015

Binding of an alpha 2 adrenergic receptor third intracellular loop peptide to G beta and the amino terminus of G alpha

artículo científico publicado en 1994

CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

artículo científico publicado en 2007

Calmodulin binding distinguishes between beta gamma subunits of activated G proteins and transducin ⬇️

artículo científico publicado el 1 de mayo de 1992

Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity

artículo científico publicado en 2007

Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels

artículo científico publicado en 2012

Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.

artículo científico publicado en 2014

Chemerin-induced arterial contraction is Gi- and calcium-dependent

artículo científico publicado en 2016

Colloquium on Signaling and Molecular Structure in Pharmacology (La Jolla, California, March 11–12, 1997) ⬇️

artículo científico publicado el 1 de julio de 1997

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response

artículo científico publicado en 2011

Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury

artículo científico publicado en 2014

Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.

artículo científico publicado en 2013

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

artículo científico publicado en 1982

Cotransfection of second and third intracellular loop fragments inhibit angiotensin AT1a receptor activation of phospholipase C in HEK-293 cells

scientific article published on 01 April 1998

Coupling an receptor peptide to G-protein: A new photolabeling agent

artículo científico publicado en 1994

Coupling efficacy and selectivity of the human mu-opioid receptor expressed as receptor-Galpha fusion proteins in Escherichia coli.

artículo científico publicado en 2000

Depicting a protein's two faces: GPCR classification by phylogenetic tree-based HMMs

artículo científico publicado en 2003

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.

artículo científico publicado en 2013

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

artículo científico publicado en 2009

Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells

artículo científico publicado en 2013

Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue.

artículo científico publicado en 2003

Diabetic neuropathy: inhibitory G protein dysfunction involves PKC-dependent phosphorylation of Goalpha.

artículo científico publicado en 2003

Differential Protein Dynamics of Regulators of G-protein Signaling: Role in Specificity of Small-molecule Inhibitors.

artículo científico publicado en 2018

Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein

artículo científico publicado en 2013

Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent

artículo científico publicado en 2009

Digoxin-Mediated Upregulation of RGS2 Protein Protects against Cardiac Injury.

artículo científico publicado en 2016

Dimerization in Aminergic G-Protein-Coupled Receptors: Application of a Hidden-Site Class Model of Evolution†

article

Effect of circulating epinephrine on platelet function and hematocrit

artículo científico publicado en 1995

Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways

artículo científico publicado en 2003

Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

artículo científico publicado en 2006

Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block

artículo científico publicado en 2007

Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.

artículo científico publicado en 2004

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions ⬇️

artículo científico publicado el 27 de noviembre de 1979

Expression of novel splice variants of the G protein subunit, Go alpha, is tissue-specific and age-dependent in the rat.

artículo científico publicado en 2002

FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.

artículo científico publicado en 2015

Fluorescence analysis of receptor-G protein interactions in cell membranes.

artículo científico publicado en 2002

Fluorescence approaches to study G protein mechanisms.

artículo científico publicado en 2002

Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening.

artículo científico publicado en 2007

Fluorescent guanine nucleotide analogs and G protein activation.

artículo científico publicado en 1994

G(i) activator region of alpha(2A)-adrenergic receptors: distinct basic residues mediate G(i) versus G(s) activation

artículo científico publicado en 1999

GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism

artículo científico publicado en 2009

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

artículo científico publicado en 2010

Gain-of-function mutation in Gnao1: a murine model of epileptiform encephalopathy (EIEE17)?

artículo científico publicado en 2014

Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma

artículo científico publicado en 2005

Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells

artículo científico publicado en 1986

Gα subunit coordinates with ephrin-B to balance self-renewal and differentiation in neural progenitor cells.

artículo científico publicado en 2010

Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart

artículo científico publicado en 2011

Gαi2 signaling: friend or foe in cardiac injury and heart failure?

artículo científico publicado en 2012

Hi-Fi transmission of periodic signals amid cell-to-cell variability.

artículo científico publicado en 2011

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay

artículo científico publicado en 2009

Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms.

artículo científico

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

artículo científico publicado en 2009

Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds

scientific article published on 18 March 2019

Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.

artículo científico publicado en 2014

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

artículo científico publicado en 2007

Identification of thieno[3,2-b]pyrrole derivatives as novel small molecule inhibitors of neurotropic alphaviruses

artículo científico publicado en 2009

Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay

scientific article published on 16 July 2019

Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes.

artículo científico publicado en 1981

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis

artículo científico publicado en 2018

In vitro protein kinase activity measurement by flow cytometry.

artículo científico publicado en 2008

Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension

artículo científico publicado en 2012

Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection.

artículo científico publicado en 2014

Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor

scientific article published on 01 December 1988

Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis.

artículo científico publicado en 2015

Interdomain interactions regulate GDP release from heterotrimeric G proteins

artículo científico publicado en 1999

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

artículo científico publicado en 2007

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

artículo científico publicado en 2013

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

artículo científico publicado en 2014

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology

artículo científico publicado en 2003

International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function

artículo científico publicado en 2005

International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature

artículo científico publicado en 2009

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

artículo científico publicado en 2005

Interplay of cysteine exposure and global protein dynamics in small-molecule recognition by a regulator of G-protein signaling protein

scientific article published on 26 December 2018

Interpreting Hydrogen-Deuterium Exchange Events in Proteins Using Atomistic Simulations: Case Studies on Regulators of G-Protein Signaling Proteins

scientific article published on 01 October 2018

Inverse agonist activity at the alpha(2A)-adrenergic receptor.

artículo científico publicado en 2001

Inverse agonist activity of agouti and agouti-related protein.

artículo científico publicado en 2003

Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins

artículo científico publicado en 2009

Large-scale purification of alpha 2-adrenergic receptor-enriched membranes from human platelets. Persistent association of guanine nucleotides with nonpurified membranes

scientific article published on 01 January 1986

Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.

artículo científico publicado en 2003

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis.

artículo científico publicado en 2017

Loss-of-Function Mutations in Human Regulator of G Protein Signaling RGS2 Differentially Regulate Pharmacological Reactivity of Resistance Vasculature

artículo científico publicado en 2019

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

artículo científico publicado en 2015

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

article by Weixing Shen et al published 1 June 2016 in Neuron

MScreen: an integrated compound management and high-throughput screening data storage and analysis system.

artículo científico publicado en 2012

Major developments in our understanding of G protein-coupled receptors

scientific article published on 01 January 2011

Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins

artículo científico publicado en 2006

Membrane organization in G-protein mechanisms.

artículo científico publicado en 1994

Methods for measuring vascular and nonvascular alpha-receptor sensitivity in humans.

artículo científico publicado en 1985

Mice with GNAO1 R209H Movement Disorder Variant Display Hyperlocomotion Alleviated by Risperidone

scientific article published on 06 January 2020

Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system

artículo científico publicado en 2008

Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics.

artículo científico publicado en 2013

Mind your salts: when the inactive constituent isn't

artículo científico publicado en 2010

Missing links: mechanisms of protean agonism

artículo científico publicado en 2007

Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide.

artículo científico publicado en 1997

Movement disorder in GNAO1 encephalopathy associated with gain-of-function mutations

artículo científico publicado en 2017

Multiple Gi protein subtypes regulate a single effector mechanism ⬇️

artículo científico publicado el 1 de noviembre de 1991

Multisite interactions of receptors and G proteins: enhanced potency of dimeric receptor peptides in modifying G protein function.

artículo científico publicado en 1994

Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.

artículo científico publicado en 2002

N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells

artículo científico publicado en 2007

NMR methods for detection of small molecule binding to RGS4.

artículo científico publicado en 2013

NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix

artículo científico publicado en 2002

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts

artículo científico publicado en 2014

Novel peptide ligands of RGS4 from a focused one-bead, one-compound library

artículo científico publicado en 2008

Optimisation of Intestinal Fibrosis and Survival in the Mouse S. Typhimurium Model for Anti-fibrotic Drug Discovery and Preclinical Applications

artículo científico publicado en 2016

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents

artículo científico publicado en 2013

Parallel inactivation of alpha 2-adrenergic agonist binding and Ni by alkaline treatment

scientific article published on 01 November 1985

Partial G protein activation by fluorescent guanine nucleotide analogs. Evidence for a triphosphate-bound but inactive state.

artículo científico publicado en 1996

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

scientific article published on 01 June 1980

Phagocyte-derived catecholamines enhance acute inflammatory injury

artículo científico publicado en 2007

Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.

artículo científico publicado en 2017

Pharmacologic reduction of sympathetic drive increases platelet alpha-2-receptor number

artículo científico publicado en 1985

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma

artículo científico publicado en 2016

Phase-locked signals elucidate circuit architecture of an oscillatory pathway

artículo científico publicado en 2010

Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele

artículo científico publicado en 2006

Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors

artículo científico publicado en 2009

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

scientific article published on 27 June 2019

RGS Proteins and Gαi2 Modulate Sleep, Wakefulness, and Disruption of Sleep/ Wake States after Isoflurane and Sevoflurane Anesthesia

artículo científico publicado en 2015

RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.

artículo científico publicado en 2010

RGS-Insensitive G Proteins as In Vivo Probes of RGS Function.

artículo científico

RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins

artículo científico publicado en 2004

RGS-insensitive Gα subunits: probes of Gα subtype-selective signaling and physiological functions of RGS proteins.

artículo científico

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury

artículo científico publicado en 2010

Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor

artículo científico publicado en 1987

Rapid kinetics of G protein subunit association: a rate-limiting conformational change?

scientific article published on 01 December 1994

Rapid kinetics of alpha 2-adrenergic inhibition of adenylate cyclase. Evidence for a distal rate-limiting step

scientific article published on 01 October 1989

Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7

artículo científico publicado en 2000

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

artículo científico publicado en 2004

Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues

artículo científico publicado en 2004

Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors

artículo científico publicado en 2005

Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells

scientific journal article

Redox modification of nuclear actin by MICAL-2 regulates SRF signaling

artículo científico publicado en 2014

Regions in the G protein gamma subunit important for interaction with receptors and effectors.

artículo científico publicado en 2005

Regulation of G protein signaling by the 70kDa heat shock protein.

artículo científico publicado en 2012

Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins

artículo científico publicado en 2013

Regulator of G Protein Signaling 6 Protects the Heart from Ischemic Injury.

artículo científico publicado en 2016

Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity

artículo científico publicado en 2009

Regulators of G protein signaling & drugs of abuse.

artículo científico publicado en 2005

Regulators of G protein signaling proteins as targets for drug discovery.

artículo científico publicado en 2010

Regulators of G-protein signalling as new central nervous system drug targets.

artículo científico publicado en 2002

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

artículo científico publicado en 2007

Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

artículo científico publicado en 2007

Resonance energy transfer between guanine nucleotide binding protein subunits and membrane lipids ⬇️

artículo científico publicado el 9 de marzo de 1993

Retracted: Mouse models of GNAO1-associated movement disorder: Allele- and sex-specific differences in phenotypes

retracted article

Reversal of chronic renal hypertension: role of salt and water excretion

artículo científico publicado en 1975

Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay

artículo científico publicado en 2013

Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins

artículo científico publicado en 2010

Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells

scientific article published on 28 October 2019

Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteins.

artículo científico publicado en 2004

Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein

artículo científico publicado en 2018

Role of signaling molecules in behaviors mediated by the δ-receptor agonist SNC80.

artículo científico publicado en 2017

Roles of G(o)alpha tryptophans in GTP hydrolysis, GDP release, and fluorescence signals

artículo científico publicado en 1998

Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) alpha and betagamma subunits by urea

artículo científico publicado en 2001

Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors

artículo científico publicado en 2015

Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate

artículo científico publicado en 1990

Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins

artículo científico publicado en 2012

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

scientific article published on 17 September 2008

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

artículo científico publicado en 2016

Spermine in semen of male sea lamprey acts as a sex pheromone

scientific article published on 09 July 2019

Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.

artículo científico publicado en 2003

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

artículo científico publicado en 2007

Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity

artículo científico publicado en 2004

Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors.

artículo científico publicado en 2004

Subsecond modulation of formyl peptide-linked guanine nucleotide-binding proteins by guanosine 5'-O-(3-thio)triphosphate in permeabilized neutrophils

scientific article published on 01 May 1993

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury

artículo científico publicado en 2014

The Concise Guide to PHARMACOLOGY 2013/14: overview

artículo científico publicado en 2013

The DRY motif and the four corners of the cubic ternary complex model.

artículo científico publicado en 2017

The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in Kras; Pdx1-Cre (KC) mice

artículo científico publicado en 2019

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

artículo científico publicado en 2006

The loss of RGS protein-Gα(i2) interactions results in markedly impaired mouse neutrophil trafficking to inflammatory sites

artículo científico publicado en 2012

The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors.

artículo científico publicado en 2016

Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.

artículo científico publicado en 2010

Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells

artículo científico publicado en 2004

Timing is everything the role of kinetics in G protein activation

scientific article published on 01 December 2000

Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Gα(i2) protein

artículo científico publicado en 2012

Under the microscope: single molecule symposium at the University of Michigan, 2006

artículo científico publicado en 2007

Use of flow cytometric methods to quantify protein-protein interactions.

artículo científico publicado en 2010

Using evolutionary methods to study G-protein coupled receptors.

artículo científico publicado en 2002

Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.

artículo científico publicado en 2000

alpha 2-Adrenoceptors take centre stage at Nashville meeting

scientific article published on 01 March 1996

p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor

artículo científico publicado en 1990

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