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Lista de obras de Wim Jiskoot

A Comprehensive Evaluation of Nanoparticle Tracking Analysis (NanoSight) for Characterization of Proteinaceous Submicron Particles.

artículo científico publicado en 2016

A Flow Imaging Microscopy-Based Method Using Mass-to-Volume Ratio to Derive the Porosity of PLGA Microparticles

scientific article published on 26 July 2017

A Liposome-Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization

artículo científico publicado en 2019

A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

artículo científico publicado en 2006

A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus ⬇️

artículo científico publicado el 4 de febrero de 2012

A new strategy to stabilize oxytocin in aqueous solutions: I. The effects of divalent metal ions and citrate buffer.

artículo científico publicado en 2011

A new strategy to stabilize oxytocin in aqueous solutions: II. Suppression of cysteine-mediated intermolecular reactions by a combination of divalent metal ions and citrate

artículo científico publicado en 2012

A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine ⬇️

artículo científico publicado el 8 de octubre de 2011

Activation of Human Monocytes by Colloidal Aluminum Salts

artículo científico publicado en 2019

Addressing the cold reality of mRNA vaccine stability

artículo científico publicado en 2020

Adjuvant effect of cationic liposomes and CpG depends on administration route.

artículo científico publicado en 2011

Adjuvant effect of cationic liposomes for subunit influenza vaccine: influence of antigen loading method, cholesterol and immune modulators

artículo científico publicado en 2013

Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: adjuvant- and site-dependent immunogenicity in mice

artículo científico publicado en 2011

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

article

Advanced therapy medicinal products: what's in a name?

artículo científico publicado en 2020

Advances in transcutaneous vaccine delivery: Do all ways lead to Rome? ⬇️

artículo científico publicado el 24 de septiembre de 2010

Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice.

artículo científico publicado en 2010

Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice

artículo científico publicado en 2018

Antibody Response Against Betaferon® in Immune Tolerant Mice: Involvement of Marginal Zone B-cells and CD4+ T-cells and Apparent Lack of Immunological Memory ⬇️

artículo científico publicado el 4 de septiembre de 2012

Antibody Response to Aggregated Human Interferon Alpha2b in Wild-type and Transgenic Immune Tolerant Mice Depends on Type and Level of Aggregation

article

Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles?

artículo científico publicado en 2010

Asymmetrical Flow Field-Flow Fractionation Method for the Analysis of Submicron Protein Aggregates ⬇️

artículo científico publicado el 21 de agosto de 2012

Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses

scientific article published on 05 December 2019

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

artículo científico publicado en 2016

Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine.

artículo científico publicado en 2016

Buccal and sublingual vaccine delivery

artículo científico publicado en 2014

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

scientific article published on 11 April 2019

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses

artículo científico publicado en 2014

CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses

article

Cathodic corrosion of a bulk wire to non-aggregated functional nanocrystals and nanoalloys.

artículo científico publicado en 2018

Cationic liposomes as adjuvants for influenza hemagglutinin: more than charge alone

scientific article published on 02 April 2012

Cationic liposomes loaded with a synthetic long peptide and poly(I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity.

artículo científico publicado en 2014

Characterization of a cyclosporine solid dispersion for inhalation

artículo científico publicado en 2007

Chemical Modifications of Silicon Surfaces for the Generation of a Tunable Surface Isoelectric Point

artículo científico publicado en 2014

Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation

artículo científico publicado en 2017

Chemical modifications in aggregates of recombinant human insulin induced by metal-catalyzed oxidation: covalent cross-linking via michael addition to tyrosine oxidation products ⬇️

artículo científico publicado en 2012

Chitosan-based delivery systems for protein therapeutics and antigens

artículo científico publicado en 2009

Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal vaccination

artículo científico publicado en 2010

Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles

artículo científico publicado en 2018

Comparison of analytical methods to detect instability of etanercept during thermal stress testing ⬇️

artículo científico publicado el 24 de enero de 2011

Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques

scientific article published on 24 April 2020

Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial

scientific article published on 05 January 2021

Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles.

artículo científico publicado en 2010

Conformational analysis of opacity proteins from Neisseria meningitidis

artículo científico publicado en 2002

Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen

artículo científico publicado en 2010

Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination

scientific article published on 20 July 2011

Critical Evaluation of Microfluidic Resistive Pulse Sensing for Quantification and Sizing of Nanometer- and Micrometer-Sized Particles in Biopharmaceutical Products

artículo científico publicado en 2018

Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

artículo científico publicado en 2010

Cytosolic delivery of liposomally targeted proteins induced by photochemical internalization

artículo científico publicado en 2007

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

artículo científico publicado en 2020

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

artículo científico publicado en 2013

Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum ⬇️

artículo científico publicado el 31 de marzo de 2012

Detergent-aided polymersome preparation

artículo científico publicado en 2010

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles.

artículo científico publicado en 2016

Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery

artículo científico publicado en 2018

Development of a bioassay for quantification of neutralising antibodies against human interferon-beta in mouse sera.

artículo científico publicado en 2008

Development of a transgenic mouse model immune tolerant for human interferon Beta.

artículo científico publicado en 2005

Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin

artículo científico publicado en 2014

Development of methods for extraction and analytical characterization of carbon-based nanomaterials (nanoplastics and carbon nanotubes) in biological and environmental matrices by asymmetrical flow field-flow fractionation

scientific article published on 26 September 2019

Dimeric IgG complexes from IVIg are incapable of inducing in vitro neutrophil degranulation or complement activation.

artículo científico publicado en 2018

Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice.

artículo científico publicado en 2017

Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs

artículo científico publicado en 2007

Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics

artículo científico publicado en 2020

Distinct conformational stability and functional activity of four highly homologous endonuclease colicins

artículo científico publicado en 2004

Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying.

artículo científico publicado en 2005

Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination

artículo científico publicado en 2010

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

artículo científico publicado en 2007

Effect of Treatment Regimen on the Immunogenicity of Human Interferon Beta in Immune Tolerant Mice ⬇️

artículo científico publicado el 30 de enero de 2013

Effect of the spraying conditions and nozzle design on the shape and size distribution of particles obtained with supercritical fluid drying.

artículo científico publicado en 2008

Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines

artículo científico publicado en 2011

Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations

artículo científico publicado en 2008

Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines.

artículo científico publicado en 2017

Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles ⬇️

artículo científico publicado el 24 de abril de 2013

Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations

artículo científico publicado en 2009

Elution behavior of insulin on high-performance size exclusion chromatography at neutral pH.

artículo científico publicado en 2010

Eprex-associated pure red cell aplasia and leachates

artículo científico publicado en 2006

Erythropoietin-Associated PRCA: Still an Unsolved Mystery

artículo científico publicado en 2006

Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes.

artículo científico publicado en 2011

Extrinsic fluorescent dyes as tools for protein characterization

artículo científico publicado en 2008

Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice

artículo científico publicado en 2016

Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation

artículo científico publicado en 2018

Flow imaging microscopy for protein particle analysis--a comparative evaluation of four different analytical instruments

artículo científico publicado en 2013

Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations ⬇️

artículo científico publicado el 5 de febrero de 2011

Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations

artículo científico publicado en 2009

Fluorescent nanoparticle adhesion assay: a novel method for surface pKa determination of self-assembled monolayers on silicon surfaces

artículo científico publicado en 2012

Forced degradation of therapeutic proteins.

artículo científico publicado en 2011

Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S

artículo científico publicado en 2020

Formation of amide- and imide-linked degradation products between the peptide drug oxytocin and citrate in citrate-buffered formulations

artículo científico publicado en 2011

Formulation of cell-based medicinal products: a question of life or death?

artículo científico publicado en 2020

Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration.

artículo científico publicado en 2017

Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins

artículo científico publicado en 2002

Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

scientific article published on 22 August 2019

Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model

artículo científico publicado en 2008

Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics ⬇️

artículo científico publicado el 27 de junio de 2012

Hollow microneedle-mediated micro-injections of a liposomal HPV E743-63 synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses

artículo científico publicado en 2017

How bio-questionable are the different recombinant human erythropoietin copy products in Thailand?

artículo científico publicado en 2013

Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment

artículo científico publicado en 2018

Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta

artículo científico publicado en 2009

Identification of Formaldehyde-Induced Modifications in Diphtheria Toxin

scientific article published on 31 October 2019

Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity ⬇️

artículo científico publicado el 2 de mayo de 2013

Identification of formaldehyde-induced modifications in proteins: reactions with insulin

artículo científico publicado en 2006

Identification of formaldehyde-induced modifications in proteins: reactions with model peptides

artículo científico publicado en 2003

IgG-loaded hyaluronan-based dissolving microneedles for intradermal protein delivery

artículo científico publicado en 2015

Immunogenicity of Therapeutic Proteins: The Use of Animal Models ⬇️

artículo científico publicado el 9 de julio de 2011

Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice ⬇️

artículo científico publicado el 5 de septiembre de 2012

Immunogenicity of diphtheria toxoid and poly(I:C) loaded cationic liposomes after hollow microneedle-mediated intradermal injection in mice

artículo científico publicado en 2018

Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres

artículo científico publicado en 2004

Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene

scientific article published on 14 September 2011

Immunological evaluation in vitro of nanoparticulate impurities isolated from pharmaceutical-grade sucrose

artículo científico publicado en 2020

Immunological mechanism underlying the immune response to recombinant human protein therapeutics

artículo científico publicado en 2009

Immunological risk of injectable drug delivery systems

scientific article published on 27 February 2009

Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity.

artículo científico publicado en 2015

Impact-insertion applicator improves reliability of skin penetration by solid microneedle arrays.

artículo científico publicado en 2014

In vitro degradation behavior of microspheres based on cross-linked dextran

artículo científico publicado en 2006

In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice

artículo científico publicado en 2013

Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans

artículo científico publicado en 2009

Influenza T-cell epitope-loaded virosomes adjuvanted with CpG as a potential influenza vaccine

artículo científico publicado en 2014

Innovative therapeutics: from molecules to medicines. 27 June-7 July 2004, Parma, Italy

artículo científico publicado en 2004

Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition

artículo científico publicado en 2004

Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles

artículo científico publicado en 2017

Intranasal immunisation of mice with liposomes containing recombinant meningococcal OpaB and OpaJ proteins.

artículo científico publicado en 2004

Label-Free, Flow-Imaging Methods for Determination of Cell Concentration and Viability.

artículo científico publicado en 2018

Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination

artículo científico publicado en 2015

Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease

artículo científico publicado en 2004

Light obscuration measurements of highly viscous solutions: sample pressurization overcomes underestimation of subvisible particle counts

artículo científico publicado en 2014

Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response.

artículo científico publicado en 2003

Lysozyme particle formation during supercritical fluid drying: Particle morphology and molecular integrity

Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ.

artículo científico publicado en 2014

Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.

artículo científico publicado en 2010

Measurement of the average mass of proteins adsorbed to a nanoparticle by using a suspended microchannel resonator

artículo científico publicado en 2014

Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination

artículo científico publicado en 2009

Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery

artículo científico publicado en 2017

Mesoporous Silica Nanoparticles with Large Pores for the Encapsulation and Release of Proteins

artículo científico publicado en 2016

Micelle-associated protein in epoetin formulations: aA risk factor for immunogenicity?

scientific article published on 01 December 2003

Micro-Flow Imaging as a quantitative tool to assess size and agglomeration of PLGA microparticles

artículo científico publicado en 2017

Microneedle technologies for (trans)dermal drug and vaccine delivery

artículo científico publicado en 2012

Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations

artículo científico publicado en 2010

Micro–Flow Imaging and Resonant Mass Measurement (Archimedes) – Complementary Methods to Quantitatively Differentiate Protein Particles and Silicone Oil Droplets ⬇️

artículo científico publicado el 26 de abril de 2013

Misconceptions over Förster resonance energy transfer between proteins and ANS/bis-ANS: Direct excitation dominates dye fluorescence

artículo científico publicado en 2010

Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations

artículo científico publicado en 2006

Models for evaluation of relative immunogenic potential of protein particles in biopharmaceutical protein formulations ⬇️

artículo científico publicado el 26 de junio de 2012

Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.

artículo científico publicado en 2014

Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model

artículo científico publicado en 2019

Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges

artículo científico publicado en 2016

Multi-antigen immunization using IgG binding domain ZZ as carrier.

artículo científico publicado en 2005

N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model

scientific article published on 04 August 2006

Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles

scientific article published on 29 July 2013

Nanoparticulate Impurities Isolated from Pharmaceutical-Grade Sucrose Are a Potential Threat to Protein Stability.

artículo científico publicado en 2017

Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations

artículo científico publicado en 2015

Nanotechnological approaches for the delivery of macromolecules

artículo científico publicado en 2003

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

artículo científico publicado en 2010

Near-infrared imaging for studying homogeneity of protein-sugar mixtures

artículo científico publicado en 2006

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.

artículo científico publicado en 2014

New method to produce equine antirabies immunoglobulin F(ab′)2 fragments from crude plasma in high quality and yield ⬇️

artículo científico publicado el 21 de marzo de 2011

No Touching! Abrasion of Adsorbed Protein Is the Root Cause of Subvisible Particle Formation During Stirring

artículo científico publicado en 2016

Novel Formaldehyde-Induced Modifications of Lysine Residue Pairs in Peptides and Proteins: Identification and Relevance to Vaccine Development

artículo científico publicado en 2020

Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats

artículo científico publicado en 2014

OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis

artículo científico publicado en 2004

On the Role of Aggregates in the Immunogenicity of Recombinant Human Interferon Beta in Patients with Multiple Sclerosis ⬇️

artículo científico publicado el 1 de octubre de 2010

Online fluorescent dye detection method for the characterization of immunoglobulin G aggregation by size exclusion chromatography and asymmetrical flow field flow fractionation

artículo científico publicado en 2008

Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines.

artículo científico publicado en 2016

Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice.

artículo científico publicado en 2014

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality

artículo científico publicado en 2009

Oxidation of therapeutic proteins and peptides: structural and biological consequences

artículo científico publicado en 2013

Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice ⬇️

artículo científico publicado el 5 de mayo de 2011

PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro

artículo científico publicado en 2013

PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity

artículo científico publicado en 2011

Parameter optimization toward optimal microneedle-based dermal vaccination.

artículo científico publicado en 2014

Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods ⬇️

artículo científico publicado el 8 de diciembre de 2011

Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen

artículo científico publicado en 2013

Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo

artículo científico publicado en 2013

Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines ⬇️

artículo científico publicado el 12 de diciembre de 2003

Physicochemical and immunological characterization of N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration

artículo científico publicado en 2009

Physicochemical studies on the stability of influenza haemagglutinin in vaccine bulk material

artículo científico publicado en 2004

Plain and Mono-pegylated Recombinant Human Insulin Exhibit Similar Stress-Induced Aggregation Profiles ⬇️

artículo científico publicado el 22 de febrero de 2011

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

artículo científico publicado en 2014

Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues

scientific article published on 14 April 2018

Potential Issues With the Handling of Biologicals in a Hospital

artículo científico publicado en 2017

Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products

artículo científico publicado en 2010

Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins ⬇️

artículo científico publicado el 7 de mayo de 2013

Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach

artículo científico publicado en 2015

Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization

artículo científico publicado en 2008

Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system

artículo científico publicado en 2005

Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery

artículo científico publicado en 2007

Probing bis-ANS binding sites of different affinity on aggregated IgG by steady-state fluorescence, time-resolved fluorescence and isothermal titration calorimetry

artículo científico publicado en 2010

Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry.

artículo científico publicado en 2002

Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release ⬇️

artículo científico publicado el 14 de diciembre de 2011

Protein-polyelectrolyte interactions: Monitoring particle formation and growth by nanoparticle tracking analysis and flow imaging microscopy

artículo científico publicado en 2015

Quality Comparison of Biosimilar and Copy Filgrastim Products with the Innovator Product

scholarly article by Liem Andhyk Halim et al published 2 October 2018 in Pharmaceutical Research

Quality and Batch-to-Batch Consistency of Original and Biosimilar Epoetin Products.

artículo científico publicado en 2016

Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques

artículo científico publicado en 2007

Quality of original and biosimilar epoetin products

artículo científico publicado en 2010

Rational design of nasal vaccines

artículo científico publicado en 2008

Reaction to the paper: interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions

artículo científico publicado en 2006

Recombinant gelatin hydrogels for the sustained release of proteins

artículo científico publicado en 2007

Reduction of animal use in human vaccine quality control: opportunities and problems

artículo científico publicado en 2002

Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine

scientific article published on 25 August 2009

Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses.

artículo científico publicado en 2016

Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes

artículo científico publicado en 2003

Restricted immune activation and internalisation of anti-idiotype complexes between drug and antidrug antibodies

artículo científico publicado en 2018

Reversible NaCl-induced aggregation of a monoclonal antibody at low pH: Characterization of aggregates and factors affecting aggregation

artículo científico publicado en 2016

Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

artículo científico publicado en 2010

Selective Production of Polymorphs and Pseudomorphs Using Supercritical Fluid Crystallization from Aqueous Solutions

Self-assembly of recombinant amphiphilic oligopeptides into vesicles.

artículo científico publicado en 2007

Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red.

artículo científico publicado en 2007

Shifting Paradigms Revisited: Biotechnology and the Pharmaceutical Sciences

scientific article published on 23 August 2019

Shifting paradigms: biopharmaceuticals versus low molecular weight drugs ⬇️

artículo científico publicado el 6 de noviembre de 2003

Simplified monopalmitoyl Toll-like receptor 2 ligand mini-UPam for self-adjuvanting neoantigen-based synthetic cancer vaccines

artículo científico publicado en 2020

Simultaneous automated image analysis and Raman spectroscopy of powders at an individual particle level

artículo científico publicado en 2020

Sizing the optimal dimensions of a vaccine delivery system: a particulate matter

artículo científico publicado en 2015

Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics

artículo científico publicado en 2015

Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation.

artículo científico publicado en 2011

Stabilised aluminium phosphate nanoparticles used as vaccine adjuvant

scientific article published on 12 June 2019

Stability of Rituximab in Freeze-Dried Formulations Containing Trehalose or Melibiose Under Different Relative Humidity Atmospheres ⬇️

artículo científico publicado el 28 de noviembre de 2012

Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines

artículo científico publicado en 2004

Stabilization of IgG by supercritical fluid drying: optimization of formulation and process parameters.

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Thermal and acid denaturation of bovine lens α‐crystallin ⬇️

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Transcutaneous immunization studies in mice using diphtheria toxoid-loaded vesicle formulations and a microneedle array

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Transient Molten Globules and Metastable Aggregates Induced by Brief Exposure of a Monoclonal IgG to Low pH ⬇️

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Virosome and ISCOM vaccines against Newcastle disease: preparation, characterization and immunogenicity

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