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Lista de obras de Orly Weinreb

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice

artículo científico publicado en 2016

A model of MPTP-induced Parkinson's disease in the goldfish

artículo científico publicado en 2007

A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing

artículo científico publicado en 2006

A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor

artículo científico publicado en 2011

A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate

artículo científico publicado en 2007

A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist

artículo científico publicado en 2018

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

artículo científico publicado en 2015

Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells

artículo científico publicado en 2016

Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1(G93A) Transgenic ALS Mice

artículo científico publicado en 2016

Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice

artículo científico publicado en 2015

Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).

artículo científico publicado en 2008

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.

artículo científico publicado en 2004

Chronic treatment with serotonin reuptake inhibitor antidepressant (SSRI) combined with an antipsychotic regulates GABA-A receptor in rat prefrontal cortex

artículo científico publicado en 2011

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

artículo científico publicado en 2014

Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease

artículo científico publicado en 2016

Does 1-(R)-aminoindan Possess Neuroprotective Properties Against Experimental Parkinson's Disease? ⬇️

artículo científico publicado el 28 de diciembre de 2010

Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice

artículo científico publicado en 2015

Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism ⬇️

artículo científico publicado el 25 de marzo de 2012

Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin

artículo científico publicado en 2003

Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine

artículo científico publicado en 2007

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.

artículo científico publicado en 2009

Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders

artículo científico publicado en 2006

Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil

artículo científico publicado en 2006

Improvement in verbal memory following SSRI augmentation of antipsychotic treatment is associated with changes in the expression of mRNA encoding for the GABA-A receptor and BDNF in PMC of schizophrenic patients

artículo científico publicado en 2015

Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy

artículo científico publicado en 2007

Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa

artículo científico publicado en 2017

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: a tribute to Moussa Youdim ⬇️

artículo científico publicado el 1 de marzo de 2011

Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment ⬇️

artículo científico publicado el 1 de abril de 2012

Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives

artículo científico publicado en 2005

Molecular mechanisms of the neuroprotective neurorescue action of multi-target green tea polyphenols ⬇️

artículo científico publicado el 1 de enero de 2012

Molecular mechanisms underlying synergistic effects of SSRI-antipsychotic augmentation in treatment of negative symptoms in schizophrenia

artículo científico publicado en 2009

Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus

artículo científico publicado en 2014

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice ⬇️

artículo científico publicado el 31 de julio de 2012

Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway

artículo científico publicado en 2005

Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs

artículo científico publicado en 2009

Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia?

artículo científico publicado en 2009

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

artículo científico publicado en 2004

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice ⬇️

artículo científico publicado el 10 de marzo de 2012

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

artículo científico publicado en 2004

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

artículo científico publicado en 2009

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

artículo científico publicado en 2014

Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets

artículo científico

Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease

artículo científico publicado en 2015

Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

scientific article published on 10 September 2009

Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities

artículo científico publicado en 2010

Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

artículo científico publicado el 1 de enero de 2011

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

artículo científico publicado en 2007

Novel Therapeutic Approach for Neurodegenerative Pathologies: Multitarget Iron-Chelating Drugs Regulating Hypoxia-Inducible Factor 1 Signal Transduction Pathway ⬇️

artículo científico publicado el 9 de diciembre de 2011

Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties

artículo científico publicado en 2007

Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway

artículo científico publicado en 2005

Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

artículo científico publicado en 2008

Proceedings from the "Third International Conference on Mechanism of Action of Nutraceuticals"

scientific article published on 01 September 2005

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

artículo científico

Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation

artículo científico publicado en 2010

Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

artículo científico publicado en 2010

Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition

artículo científico publicado en 2005

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application ⬇️

artículo científico publicado el 29 de junio de 2010

Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

artículo científico publicado en 2005

SSRI augmentation of antipsychotic alters expression of GABAA receptor and related genes in PMC of schizophrenia patients ⬇️

artículo científico publicado el 16 de diciembre de 2010

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.

artículo científico publicado en 2008

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators ⬇️

artículo científico publicado el 30 de enero de 2013

The Multi-Target Drug M30 Shows Pro-Cognitive and Anti-Inflammatory Effects in a Rat Model of Alzheimer's Disease

artículo científico publicado en 2015

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease ⬇️

artículo científico publicado el 17 de abril de 2012

The Role of GABA-A Receptor in the Synergism Between SSRI and Antipsychotic in Schizophrenia; Implications for Antipsychotic Modes of Actions ⬇️

artículo científico publicado el 1 de enero de 2013

The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection

artículo científico publicado en 2007

The application of proteomics for studying the neurorescue activity of the polyphenol (-)-epigallocatechin-3-gallate

artículo científico publicado en 2008

The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex

artículo científico publicado en 2005

The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia

artículo científico publicado en 2017

The involvement of GABA(A) receptor in the molecular mechanisms of combined selective serotonin reuptake inhibitor-antipsychotic treatment

artículo científico publicado en 2010

The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity

scientific journal article

The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline

scientific article published on 10 December 2009

The neuroprotective mechanism of action of the multimodal drug ladostigil

artículo científico publicado en 2008

The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats

artículo científico publicado en 2008

The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice

artículo científico publicado en 2014

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models

artículo científico publicado en 2017

Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases ⬇️

artículo científico publicado el 1 de enero de 2011

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

artículo científico publicado en 2003

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

artículo científico publicado en 2004

cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

artículo científico publicado en 2003

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