Lista de obras - Motohiro Nishida - Dominio Público Uruguay

2-Oxo-histidine-containing dipeptides are functional oxidation products

artículo científico publicado en 2018

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

artículo científico publicado en 2008

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy.

artículo científico publicado en 2017

Activation Mechanism of Gi and Go by Reactive Oxygen Species ⬇️

artículo científico publicado el 7 de enero de 2002

Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration.

artículo científico publicado en 2009

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

artículo científico publicado en 2003

Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii.

artículo científico publicado en 2006

Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity ⬇️

scientific article published on 13 January 2020

Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway

Caveolae-independent activation of protein kinase A in rat neonatal myocytes.

artículo científico publicado en 2005

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.

artículo científico publicado en 2011

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

artículo científico publicado en 2017

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

scientific article published on 25 June 2019

Determining the activation of rho as an index of receptor coupling to G₁₂/₁₃ proteins.

artículo científico publicado en 2011

Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation

scientific article published on 01 March 2003

Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel.

artículo científico publicado en 2003

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

artículo científico publicado en 2015

Dual actions of ANP on endothelial permeability

Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat

artículo científico publicado en 2011

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

artículo científico publicado en 2017

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide ⬇️

artículo científico publicado el 28 de abril de 2013

G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.

artículo científico publicado en 2005

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance ⬇️

artículo científico publicado el 1 de enero de 2013

Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

scientific journal article

Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.

artículo científico publicado en 2005

Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.

artículo científico publicado en 2007

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y 2 receptor stimulation through S-nitrosylation of NF-κB ⬇️

artículo científico publicado el 4 de abril de 2011

Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts.

artículo científico publicado en 2006

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.

artículo científico publicado en 2003

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

artículo científico publicado en 2012

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

artículo científico publicado en 2018

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

scientific article published on 06 August 2019

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.

artículo científico publicado en 2012

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

artículo científico publicado en 2014

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.

artículo científico publicado en 2010

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

artículo científico publicado en 2017

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

artículo científico publicado en 2008

Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer

artículo científico publicado en 2022

Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis ⬇️

artículo científico publicado el 18 de julio de 2012

Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels

scientific article published on 01 March 2010

Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity

artículo científico publicado en 2011

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.

artículo científico publicado en 2016

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts

artículo científico publicado en 2017

Mitochondrial dynamics in exercise physiology

scientific article published on 01 February 2019

Mutations in EFHC1 cause juvenile myoclonic epilepsy

artículo científico publicado en 2004

Novel real-time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate production in intact cells.

artículo científico publicado en 2004

Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

artículo científico publicado en 2010

Pharmacological properties of novel TRPC channel inhibitors

artículo científico publicado en 2010

Prolonged stimulation of β-adrenergic receptor with β-agonists impairs insulin actions in H9c2 cells

artículo científico publicado en 2018

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases.

artículo científico publicado en 2017

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

artículo científico publicado en 2016

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.

artículo científico publicado en 2017

Purinergic signaling in cardiovascular system.

artículo científico publicado en 2017

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

artículo científico publicado en 2018

Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.

artículo científico publicado en 2015

Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

artículo científico publicado en 2012

Redox Control of Cardiovascular Homeostasis by Angiotensin II ⬇️

artículo científico publicado el 1 de enero de 2013

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.

artículo científico publicado en 2017

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

artículo científico publicado en 2016

Redox signaling regulated by electrophiles and reactive sulfur species

artículo científico publicado en 2016

Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB ⬇️

artículo científico publicado el 13 de noviembre de 2010

Regulation of redox homeostasis by hydrogen sulfide anion and its clinical application

artículo científico publicado en 2013

Regulation of redox signalling by an electrophilic cyclic nucleotide ⬇️

artículo científico publicado el 17 de diciembre de 2012

Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling.

artículo científico

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology.

artículo científico publicado en 2017

Roles of heterotrimeric GTP-binding proteins in the progression of heart failure.

artículo científico

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

artículo científico publicado en 2016

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

artículo científico publicado en 2017

Sulfide catabolism ameliorates hypoxic brain injury

scientific article published on 25 May 2021

Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.

artículo científico publicado en 2015

TRPC channels in exercise-mimetic therapy

artículo científico publicado en 2018

TRPC3 Channels in Cardiac Fibrosis.

artículo científico publicado en 2017

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation.

artículo científico publicado en 2015

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca(2+) concentration in mouse cardiomyocytes

artículo científico publicado en 2017

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

artículo científico publicado en 2016

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

artículo científico publicado en 2016

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

scientific article published on 05 July 2019

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.

artículo científico publicado en 2017

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

artículo científico publicado en 2011

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.

artículo científico publicado en 2018

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

artículo científico publicado en 2017

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

artículo científico publicado en 2019

Transient receptor potential channels in Alzheimer's disease.

artículo científico publicado en 2007

Transient receptor potential channels in cardiovascular function and disease.

artículo científico publicado en 2006

[ Frontiers of Ca(2+) signaling~physiological and pathological roles of voltage-independent Ca(2+) channels]

scientific article published on 01 March 2010

[Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological potentiality]

artículo científico publicado en 2015

[Chemical biology of hydrogen sulfide]

artículo científico publicado en 2013

[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species].

artículo científico publicado en 2014

[Function and role of transient receptor potential channels]

artículo científico publicado en 2013

[Lifestyle Inspires Future Pharmacotherapy and Drug Discovery]

artículo científico publicado en 2018

[Molecular mechanism underlying the development of heart failure mediated by heterotrimeric G protein signaling]

scientific article published on 01 May 2010

[New Strategies for Exercise-Mimetic Medication]

artículo científico publicado en 2018

[Novel findings in functions of TRP channel protein and pathophysiology]

[Regulation of cardiovascular functions by the phosphorylation of TRPC channels].

artículo científico publicado en 2010

[Signal transduction in the development of vascular disease and new therapeutic strategy]

scientific article published on 01 November 2010

[TRPC channels and cardiac hypertrophy]

scientific article published on 01 October 2007

[TRPC]

scientific article published on 01 August 2008

β-arrestin2 in Infiltrated Macrophages Inhibits Excessive Inflammation after Myocardial Infarction ⬇️

artículo científico publicado el 8 de julio de 2013

Lista de obras de Motohiro Nishida

2-Oxo-histidine-containing dipeptides are functional oxidation products

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy.

Activation Mechanism of Gi and Go by Reactive Oxygen Species ⬇️

Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration.

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii.

Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity ⬇️

Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway

Caveolae-independent activation of protein kinase A in rat neonatal myocytes.

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Determining the activation of rho as an index of receptor coupling to G₁₂/₁₃ proteins.

Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation

Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel.

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

Dual actions of ANP on endothelial permeability

Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide ⬇️

G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance ⬇️

Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.

Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y 2 receptor stimulation through S-nitrosylation of NF-κB ⬇️

Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts.

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer

Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis ⬇️

Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels

Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts

Mitochondrial dynamics in exercise physiology

Mutations in EFHC1 cause juvenile myoclonic epilepsy

Novel real-time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate production in intact cells.

Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

Pharmacological properties of novel TRPC channel inhibitors

Prolonged stimulation of β-adrenergic receptor with β-agonists impairs insulin actions in H9c2 cells

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases.

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.

Purinergic signaling in cardiovascular system.

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.

Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

Redox Control of Cardiovascular Homeostasis by Angiotensin II ⬇️

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

Redox signaling regulated by electrophiles and reactive sulfur species

Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB ⬇️

Regulation of redox homeostasis by hydrogen sulfide anion and its clinical application

Regulation of redox signalling by an electrophilic cyclic nucleotide ⬇️

Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling.

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology.

Roles of heterotrimeric GTP-binding proteins in the progression of heart failure.

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

Sulfide catabolism ameliorates hypoxic brain injury

Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.

TRPC channels in exercise-mimetic therapy

TRPC3 Channels in Cardiac Fibrosis.

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation.

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca(2+) concentration in mouse cardiomyocytes

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts