Lista de obras - Richard Williams - Dominio Público Uruguay

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

artículo científico publicado en 2009

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

artículo científico publicado en 2007

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7

artículo científico publicado en 2009

Corrigendum to "Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres" [Bioorg. Med. Chem. Lett. 24 (2014) 1062-1066]

artículo científico publicado en 2017

Design of potent GlyT1 inhibitors: in vitro and in vivo profiles

artículo científico publicado en 2008

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

artículo científico publicado en 2019

Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold ⬇️

artículo científico publicado el 23 de octubre de 2012

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

artículo científico

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

artículo científico publicado en 2008

Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe

artículo científico publicado en 2009

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

artículo científico publicado en 2010

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

artículo científico publicado en 2008

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead

artículo científico publicado en 2014

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres

artículo científico publicado en 2014

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

artículo científico publicado en 2012

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

artículo científico publicado en 2009

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

artículo científico publicado en 2010

Recent progress in the development of allosteric modulators of mGluR5.

artículo científico publicado en 2007

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

artículo científico publicado en 2009

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold ⬇️

artículo científico publicado el 18 de enero de 2011

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

artículo científico publicado en 2010

Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS

artículo científico

Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists

artículo científico publicado en 2008

Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273

artículo científico publicado en 2009

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

artículo científico publicado en 2009

Lista de obras de Richard Williams

A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7

Corrigendum to "Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres" [Bioorg. Med. Chem. Lett. 24 (2014) 1062-1066]

Design of potent GlyT1 inhibitors: in vitro and in vivo profiles

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold ⬇️

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

Recent progress in the development of allosteric modulators of mGluR5.

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold ⬇️

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS

Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists

Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning