Lista de obras - Jason S McLellan - Dominio Público Uruguay

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

artículo científico publicado en 2021

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

artículo científico publicado en 2015

A high-throughput inhibition assay to study MERS-CoV antibody interactions using image cytometry

scientific article published on 20 November 2018

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.

artículo científico publicado en 2017

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

artículo científico publicado en 2015

A proof of concept for structure-based vaccine design targeting RSV in humans

scientific article published on 01 August 2019

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

artículo científico publicado en 2012

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

artículo científico

Alternative conformations of a major antigenic site on RSV F

artículo científico publicado en 2019

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

scientific article published on 17 November 2020

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

artículo científico publicado en 2020

Broad neutralization of SARS-related viruses by human monoclonal antibodies

artículo científico publicado en 2020

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

artículo científico publicado en 2020

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

artículo científico publicado en 2015

Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus

scientific article published on 08 May 2020

Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses

artículo científico publicado en 2017

Clinical Potential of Prefusion RSV F-specific Antibodies.

artículo científico publicado en 2017

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

artículo científico publicado en 2011

Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures

scientific article published on 08 July 2020

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

artículo científico publicado en 2020

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

artículo científico publicado en 2017

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

artículo científico publicado en 2020

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

artículo científico publicado en 2020

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

scientific article published on 19 February 2020 in Science

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

artículo científico publicado en 2022

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

scientific article published on 11 December 2019

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

artículo científico publicado en 2010

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

artículo científico publicado en 2011

Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus

artículo científico publicado en 2017

Data publication with the structural biology data grid supports live analysis

artículo científico publicado en 2016

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

artículo científico publicado en 2011

Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab

artículo científico publicado en 2017

Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses

artículo científico publicado en 2019

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

artículo científico publicado en 2021

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

artículo científico publicado en 2012

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.

artículo científico publicado en 2016

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.

artículo científico publicado en 2015

Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F2 Subunit are Critical for its Fusion Activity.

artículo científico publicado en 2018

Global site-specific analysis of glycoprotein N-glycan processing.

artículo científico publicado en 2018

HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization

artículo científico publicado en 2020

Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.

artículo científico publicado en 2014

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

artículo científico publicado en 2017

Immunogenicity of a DNA vaccine candidate for COVID-19

scientific article published on 20 May 2020

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

artículo científico publicado en 2018

Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.

artículo científico publicado en 2017

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

artículo científico publicado en 2012

Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation

artículo científico publicado en 2018

Infection with MERS-CoV causes lethal pneumonia in the common marmoset

artículo científico publicado en 2014

Iterative screen optimization maximizes the efficiency of macromolecular crystallization

artículo científico publicado en 2019

Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway

artículo científico publicado en 2007

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

artículo científico publicado en 2020

Local computational methods to improve the interpretability and analysis of cryo-EM maps

artículo científico publicado en 2020

Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas

artículo científico publicado en 2020

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

artículo científico publicado en 2020

Molecular mechanism of respiratory syncytial virus fusion inhibitors ⬇️

artículo científico publicado en 2015

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

artículo científico publicado en 2013

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.

artículo científico publicado en 2017

Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein.

artículo científico

Novel antigens for RSV vaccines

artículo científico publicado en 2015

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

scientific article published on 31 August 2016

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

artículo científico publicado en 2017

Pre-fusion structure of a human coronavirus spike protein.

artículo científico publicado en 2016

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

artículo científico publicado en 2015

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

artículo científico publicado en 2020

Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

artículo científico publicado en 2018

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine.

artículo científico publicado en 2016

Rapid development of a synthetic DNA vaccine for COVID-19

artículo científico publicado en 2020

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

artículo científico publicado en 2016

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

artículo científico publicado en 2018

Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step

artículo científico publicado en 2020

Respiratory syncytial virus entry and how to block it

artículo científico publicado en 2019

Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.

artículo científico publicado en 2011

SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma

artículo científico publicado en 2020

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

artículo científico publicado en 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

artículo científico publicado en 2020

Site-specific analysis of the SARS-CoV-2 glycan shield

artículo científico publicado en 2020

Site-specific glycan analysis of the SARS-CoV-2 spike

artículo científico publicado en 2020

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

artículo científico publicado en 2020

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

artículo científico publicado en 2018

Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle

artículo científico publicado en 2012

Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

artículo científico publicado en 2012

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

artículo científico publicado en 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

artículo científico publicado en 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

artículo científico publicado en 2020

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

artículo científico publicado en 2019

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

artículo científico publicado en 2014

Structural and molecular basis for Ebola virus neutralization by protective human antibodies

artículo científico publicado en 2016

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

artículo científico publicado en 2013

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.

artículo científico publicado en 2018

Structural basis of respiratory syncytial virus neutralization by motavizumab

artículo científico publicado en 2010

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.

artículo científico publicado en 2017

Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development

artículo científico publicado en 2016

Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38

scientific article published on 31 March 2020

Structure and function of respiratory syncytial virus surface glycoproteins.

artículo científico publicado en 2013

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein.

artículo científico publicado en 2017

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

artículo científico publicado en 2006

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

artículo científico publicado en 2011

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

artículo científico publicado en 2013

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

artículo científico publicado en 2011

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

artículo científico publicado en 2010

Structure of a heparin-dependent complex of Hedgehog and Ihog

artículo científico publicado en 2006

Structure of the Respiratory Syncytial Virus Polymerase Complex

artículo científico publicado en 2019

Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development

artículo científico publicado en 2020

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

artículo científico publicado en 2020

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

artículo científico publicado en 2013

Structure-Based Vaccine Antigen Design

scientific article published on 01 January 2019

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

artículo científico publicado en 2020

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

artículo científico publicado en 2020

Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants

artículo científico publicado en 2020

Synthesis of 2,6-dideoxysugars via ring-closing olefinic metathesis

scientific article published on 01 October 2002

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.

artículo científico publicado en 2013

The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation

scientific article published on 13 November 2019

The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes

artículo científico publicado en 2022

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

artículo científico publicado en 2008

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

artículo científico publicado en 2021

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

scholarly article by Natalie I Mazur et al published October 2018 in Lancet Infectious Diseases

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

artículo científico publicado en 2017

Transient opening of trimeric prefusion RSV F proteins

artículo científico publicado en 2019

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses

artículo científico publicado en 2021

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

artículo científico publicado en 2013

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

artículo científico publicado en 2020

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

artículo científico publicado en 2020

Lista de obras de Jason S McLellan

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

A high-throughput inhibition assay to study MERS-CoV antibody interactions using image cytometry

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

A proof of concept for structure-based vaccine design targeting RSV in humans

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

Alternative conformations of a major antigenic site on RSV F

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus

Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses

Clinical Potential of Prefusion RSV F-specific Antibodies.

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus

Data publication with the structural biology data grid supports live analysis

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab

Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.

Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F2 Subunit are Critical for its Fusion Activity.

Global site-specific analysis of glycoprotein N-glycan processing.

HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization

Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

Immunogenicity of a DNA vaccine candidate for COVID-19

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation

Infection with MERS-CoV causes lethal pneumonia in the common marmoset

Iterative screen optimization maximizes the efficiency of macromolecular crystallization

Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

Local computational methods to improve the interpretability and analysis of cryo-EM maps

Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

Molecular mechanism of respiratory syncytial virus fusion inhibitors ⬇️

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.

Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein.

Novel antigens for RSV vaccines

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

Pre-fusion structure of a human coronavirus spike protein.

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine.

Rapid development of a synthetic DNA vaccine for COVID-19

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step

Respiratory syncytial virus entry and how to block it

Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.

SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Site-specific analysis of the SARS-CoV-2 glycan shield

Site-specific glycan analysis of the SARS-CoV-2 spike

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis