Filtros de búsqueda

Lista de obras de P Hantraye

11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

artículo científico publicado en 2007

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina

artículo científico publicado en 2017

A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor

artículo científico publicado en 2012

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

artículo científico publicado en 2013

A standardized method to automatically segment amyloid plaques in Congo Red stained sections from Alzheimer transgenic mice

artículo científico publicado en 2007

A validation dataset for Macaque brain MRI segmentation

artículo científico publicado en 2017

Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

artículo científico publicado en 2007

Advanced imaging of transplant survival, fate, differentiation, and integration

artículo científico publicado en 2017

Age-associated cerebral atrophy in mouse lemur primates

artículo científico publicado en 2009

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

artículo científico publicado en 2008

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

artículo científico publicado en 2014

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

artículo científico publicado en 2016

Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo

artículo científico publicado en 2012

Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

scientific article published on 30 November 2019

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

artículo científico publicado en 2008

Arterial input function measurement without blood sampling using a beta-microprobe in rats

artículo científico publicado en 2004

Assessment of simplified methods for quantification of [18F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate

scientific article published on 25 June 2019

Automated Individualization of Size-Varying and Touching Neurons in Macaque Cerebral Microscopic Images

artículo científico publicado en 2019

Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas ⬇️

artículo científico publicado el 1 de enero de 2010

Automated three-dimensional analysis of histological and autoradiographic rat brain sections: application to an activation study

artículo científico publicado en 2007

B(0) homogeneity throughout the monkey brain is strongly improved in the sphinx position as compared to the supine position.

artículo científico publicado en 2006

Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates

scientific article published on 02 December 2019

Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation.

artículo científico publicado en 2006

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

artículo científico publicado en 2003

Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.

artículo científico publicado en 2009

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

artículo científico publicado en 2006

Clinical relevance of electrophysiological tests in the assessment of patients with Huntington's disease.

artículo científico publicado en 2002

Clustering of Tau fibrils impairs the synaptic composition of α3-Na/K-ATPase and AMPA receptors

article

Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates

artículo científico publicado en 2020

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

scientific article published on 18 February 2020

Correction: IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian Primates

artículo científico publicado en 2013

Cortical areas involved in behavioral expression of external pallidum dysfunctions: A PET imaging study in non-human primates

artículo científico publicado en 2016

Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration

scientific journal article

Current status of neuronal cell xenotransplantation.

artículo científico

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

artículo científico publicado en 2006

Decrease of nicotinic receptors in the nigrostriatal system in Parkinson's disease.

artículo científico publicado en 2009

Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy.

artículo científico publicado en 2002

Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1

scientific journal article

Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys

artículo científico publicado en 2000

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease.

artículo científico publicado en 2010

Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease

artículo científico publicado en 2014

Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain.

artículo científico publicado en 2008

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo

artículo científico publicado en 2019

Dopamine D1 receptor imaging in the rodent and primate brain using the isoquinoline +-[11C]A-69024 and positron emission tomography

scientific article published on 01 July 2008

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

artículo científico publicado en 2008

Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.

artículo científico publicado en 2009

Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease

artículo científico publicado en 2002

Ectosomes: a new mechanism for non-exosomal secretion of tau protein

artículo científico publicado en 2014

Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study

artículo científico publicado en 2006

Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate

artículo científico publicado en 2003

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

artículo científico publicado en 2004

Engineered lentiviral vector targeting astrocytes in vivo

artículo científico publicado en 2009

Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

artículo científico publicado en 2017

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

artículo científico publicado en 2007

Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance.

artículo científico publicado en 2018

Fetal neural grafts for Huntington's disease: a prospective view

artículo científico publicado en 2002

Fully automated and adaptive detection of amyloid plaques in stained brain sections of Alzheimer transgenic mice

scientific article published on 01 January 2007

Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation

artículo científico publicado en 2004

Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice.

artículo científico publicado en 2011

Gene Therapy for Parkinson's Disease: Preclinical Evaluation of Optimally Configured TH:CH1 Fusion for Maximal Dopamine Synthesis

artículo científico publicado en 2019

Glycolysis versus TCA cycle in the primate brain as measured by combining 18F-FDG PET and 13C-NMR.

artículo científico publicado en 2005

High-throughput 3D whole-brain quantitative histopathology in rodents.

artículo científico publicado en 2016

Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease

artículo científico publicado en 2014

Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution

artículo científico publicado en 2009

IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats

artículo científico publicado en 2007

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates

artículo científico publicado en 2013

Imaging in cell-based therapy for neurodegenerative diseases.

artículo científico publicado en 2005

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions

artículo científico publicado en 2014

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

artículo científico publicado en 2020

In Vivo Multidimensional Brain Imaging in Huntington's Disease Animal Models

artículo científico publicado en 2018

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

artículo científico publicado en 2003

In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin

artículo científico publicado en 2012

In vivo evidence for the selective subcortical degeneration in Huntington's disease.

artículo científico publicado en 2009

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

artículo científico publicado en 2010

In vivo imaging of integration and function of striatal grafts in rodent and nonhuman primate animal models

artículo científico publicado en 2012

In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa).

artículo científico publicado en 2010

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe

artículo científico publicado en 2002

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease.

artículo científico publicado en 2011

Insulin growth factor-1 protects against excitotoxicity in the rat striatum

artículo científico publicado en 2004

Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease

artículo científico publicado en 2004

Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy.

artículo científico publicado en 2013

Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

scientific article published on 03 September 2019

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

artículo científico publicado en 2006

Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by 1H nuclear magnetic resonance spectroscopy of the monkey brain.

artículo científico publicado en 2006

Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain

artículo científico publicado en 2013

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

artículo científico publicado en 2002

Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease

article

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.

artículo científico publicado en 2014

Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates

artículo científico publicado en 2019

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

artículo científico publicado en 2014

MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

artículo científico publicado en 2019

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease

artículo científico publicado en 2018

Multiinjection approach for D2 receptor binding quantification in living rats using [11C]raclopride and the beta-microprobe: crossvalidation with in vitro binding data.

artículo científico publicado en 2005

Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis

scholarly article

NMR measurement of brain oxidative metabolism in monkeys using 13C-labeled glucose without a 13C radiofrequency channel.

artículo científico publicado en 2004

Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes

artículo científico publicado en 2020

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

artículo científico publicado en 2014

Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain.

artículo científico publicado en 2005

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

artículo científico publicado en 2016

Normal aging modulates the neurotoxicity of mutant huntingtin

artículo científico publicado en 2009

Novel therapies in the search for a cure for Huntington's disease

artículo científico publicado en 2001

Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system

artículo científico publicado en 2005

Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

artículo científico publicado en 2021

PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models

artículo científico publicado en 2020

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

artículo científico publicado en 2009

Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo.

artículo científico publicado en 2004

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

artículo científico publicado en 2017

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

artículo científico publicado en 2017

Primatologist: A modular segmentation pipeline for macaque brain morphometry.

artículo científico publicado en 2017

Quantitative assessment of transcriptome differences between brain territories

artículo científico publicado en 2003

Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models

artículo científico publicado en 2008

Quantitative validation of voxel-wise statistical analyses of autoradiographic rat brain volumes: application to unilateral visual stimulation

artículo científico publicado en 2007

Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.

artículo científico publicado en 2012

Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

artículo científico publicado en 2019

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

artículo científico publicado en 2000

Restricted transgene expression in the brain with cell-type specific neuronal promoters

artículo científico publicado en 2012

Restricted transgene expression in the brain with cell-type specific neuronal promoters

Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration

artículo científico publicado en 1997

Segmentation of small animal PET/CT mouse brain scans using an MRI-based 3D digital atlas

artículo científico publicado en 2010

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

artículo científico publicado en 2010

Simplified (13)C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo.

artículo científico publicado en 2009

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo

artículo científico publicado en 2014

Striatal neural grafting improves cortical metabolism in Huntington's disease patients

artículo científico publicado en 2003

Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate.

artículo científico publicado en 2017

Sustained effects of nonallele-specific Huntingtin silencing

artículo científico publicado en 2009

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

artículo científico publicado en 2015

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

scientific article published on 09 October 2019

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

artículo científico publicado en 2015

The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study

artículo científico publicado en 2015

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

artículo científico publicado en 2018

Three-dimensional SPACE fluid-attenuated inversion recovery at 3 T to improve subthalamic nucleus lead placement for deep brain stimulation in Parkinson's disease: from preclinical to clinical studies

artículo científico publicado en 2016

Three-dimensional reconstruction of stained histological slices and 3D non-linear registration with in-vivo MRI for whole baboon brain

artículo científico publicado en 2007

Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation.

artículo científico publicado en 2005

Translational research for Parkinson׳s disease: The value of pre-clinical primate models.

artículo científico

Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue.

artículo científico publicado en 2003

Transplants of CNTF-producing Cells for the Treatment of Huntington's Disease

article

Up-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvement.

artículo científico publicado en 2004

Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging

scientific article published on 15 November 2018

[Imaging and translational research: neurodegenerative diseases]

artículo científico publicado en 2009

mRNA trans-splicing in gene therapy for genetic diseases

artículo científico publicado en 2016

miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

scientific article published on 17 September 2020

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.

artículo científico publicado en 2012

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.

artículo científico publicado en 2017

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda