Lista de obras - Malú Gámez Tansey - Dominio Público Uruguay

A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets

artículo científico

AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease

artículo científico publicado en 2014

Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration

artículo científico publicado en 2015

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

artículo científico publicado en 2018

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice

artículo científico publicado en 2013

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

artículo científico publicado en 1998

Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease

artículo científico publicado en 2007

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

artículo científico publicado en 2006

Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells

artículo científico publicado en 1994

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease

artículo científico

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

artículo científico publicado en 2012

Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

artículo científico publicado en 2016

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study

artículo científico publicado en 2015

Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation

artículo científico publicado en 2013

Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease

artículo científico publicado en 2010

Does neuroinflammation fan the flame in neurodegenerative diseases?

artículo científico publicado en 2009

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120).

artículo científico publicado en 2013

Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists

artículo científico publicado en 2000

GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

artículo científico publicado en 2000

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family ⬇️

artículo científico publicado el 12 de mayo de 1998

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants

artículo científico publicado en 2003

Inflammation in neuropsychiatric disease

artículo científico publicado en 2009

Inflammatory mechanisms contribute to microembolism-induced anxiety-like and depressive-like behaviors

artículo científico publicado en 2016

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells

artículo científico publicado en 1997

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

artículo científico publicado en 2009

Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats

artículo científico publicado en 2008

Isolation of murine postnatal brain microglia for phenotypic characterization using magnetic cell separation technology

artículo científico publicado en 2013

LRRK2 levels in immune cells are increased in Parkinson's disease

artículo científico publicado en 2017

Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

artículo científico publicado en 2011

Microglia isolation from adult mouse brain

artículo científico publicado en 2013

Microglial phenotypes in Parkinson's disease and animal models of the disease

artículo científico publicado en 2016

Modeling neuroinflammatory pathogenesis of Parkinson’s disease

artículo científico publicado el 1 de enero de 2010

Myosin Light Chain Kinase Phosphorylation: Regulation of the Ca2+ Sensitivity of Contractile Elements ⬇️

artículo científico publicado el 1 de enero de 1991

Myosin phosphorylation in smooth and skeletal muscles: regulation and function.

artículo científico

Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease? ⬇️

artículo científico publicado el 1 de agosto de 2012

Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer's disease.

artículo científico publicado en 2008

Neuroinflammation in Parkinson's disease

scientific article published on 10 October 2009

Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

artículo científico publicado en 2008

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

artículo científico publicado en 2009

Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention

artículo científico publicado en 2007

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

artículo científico publicado en 1997

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

artículo científico publicado en 2006

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

artículo científico publicado en 2008

Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice

artículo científico publicado en 2017

Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats

artículo científico publicado en 2014

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

artículo científico publicado en 2017

Persephin, a novel neurotrophic factor related to GDNF and neurturin

artículo científico publicado en 1998

Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization

artículo científico publicado en 1993

Physiology of RGS10 in Neurons and Immune Cells

artículo científico

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

artículo científico publicado en 2013

Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

artículo científico publicado en 2012

Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards ⬇️

artículo científico publicado el 4 de abril de 2012

RGS10 Negatively Regulates Platelet Activation and Thrombogenesis

artículo científico publicado en 2016

RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis

artículo científico publicado en 2016

RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells

artículo científico publicado en 2012

RNF11 modulates microglia activation through NF-κB signalling cascade

artículo científico publicado en 2012

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer's (HEART) Trial

artículo científico publicado en 2017

Regulation of microglia effector functions by tumor necrosis factor signaling

artículo científico publicado en 2011

Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response

artículo científico publicado en 2008

Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats

artículo científico publicado en 2011

Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions

artículo científico publicado en 2014

Stool immune profiles evince gastrointestinal inflammation in Parkinson's disease.

artículo científico publicado en 2018

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

artículo científico publicado en 2008

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

artículo científico publicado en 2017

The neuro-glial properties of adipose-derived adult stromal (ADAS) cells are not regulated by Notch 1 and are not derived from neural crest lineage

artículo científico publicado en 2008

The role of innate and adaptive immunity in Parkinson's disease

artículo científico

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

artículo científico publicado en 2008

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

artículo científico publicado en 2017

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

artículo científico publicado en 2016

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

artículo científico publicado en 1997

Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility

artículo científico publicado en 2013

Workshop summary: roles of the TNF family in neuronal development, function and pathology.

artículo científico publicado en 2011

c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway.

artículo científico publicado en 2001

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson's Disease Pathogenesis

scholarly article by Laura M Butkovich et al published 2018 in Frontiers in Neuroscience

Lista de obras de Malú Gámez Tansey

A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets

AAV-dominant negative tumor necrosis factor (DN-TNF) gene transfer to the striatum does not rescue medium spiny neurons in the YAC128 mouse model of Huntington's disease

Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) mice

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex

Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells

Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson's disease

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study

Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation

Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease

Does neuroinflammation fan the flame in neurodegenerative diseases?

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120).

Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists

GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family ⬇️

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants

Inflammation in neuropsychiatric disease

Inflammatory mechanisms contribute to microembolism-induced anxiety-like and depressive-like behaviors

Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats

Isolation of murine postnatal brain microglia for phenotypic characterization using magnetic cell separation technology

LRRK2 levels in immune cells are increased in Parkinson's disease

Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

Microglia isolation from adult mouse brain

Microglial phenotypes in Parkinson's disease and animal models of the disease

Modeling neuroinflammatory pathogenesis of Parkinson’s disease

Myosin Light Chain Kinase Phosphorylation: Regulation of the Ca2+ Sensitivity of Contractile Elements ⬇️

Myosin phosphorylation in smooth and skeletal muscles: regulation and function.

Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease? ⬇️

Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer's disease.

Neuroinflammation in Parkinson's disease

Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?

Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

Parkinsonism without dopamine neuron degeneration in aged l-dopa-responsive dystonia knockin mice

Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

Persephin, a novel neurotrophic factor related to GDNF and neurturin

Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca2+ desensitization

Physiology of RGS10 in Neurons and Immune Cells

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards ⬇️

RGS10 Negatively Regulates Platelet Activation and Thrombogenesis

RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis

RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells

RNF11 modulates microglia activation through NF-κB signalling cascade

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer's (HEART) Trial

Regulation of microglia effector functions by tumor necrosis factor signaling

Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response

Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats

Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions

Stool immune profiles evince gastrointestinal inflammation in Parkinson's disease.

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

The neuro-glial properties of adipose-derived adult stromal (ADAS) cells are not regulated by Notch 1 and are not derived from neural crest lineage

The role of innate and adaptive immunity in Parkinson's disease

The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

Therapeutic inhibition of soluble brain TNF promotes remyelination by increasing myelin phagocytosis by microglia

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility

Workshop summary: roles of the TNF family in neuronal development, function and pathology.

c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway.

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson's Disease Pathogenesis