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A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies

artículo científico publicado en 2008

A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

artículo científico publicado en 2006

A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia

scientific article published on 29 March 2006

A potential role for HSP90 inhibitors in the treatment of JAK2 mutant-positive diseases as demonstrated using quantitative flow cytometry

artículo científico publicado en 2007

A prognostic model for survival in chronic lymphocytic leukaemia based on p53 expression

artículo científico publicado en 2003

A randomized trial of liposomal daunorubicin and cytarabine versus liposomal daunorubicin and topotecan with or without thalidomide as initial therapy for patients with poor prognosis acute myelogenous leukemia or myelodysplastic syndrome

artículo científico publicado en 2003

A real-world, comparative study of FDA-approved diagnostic assays PD-L1 IHC 28-8 and 22C3 in lung cancer and other malignancies

artículo científico publicado en 2018

ATM mutations and protein expression are not associated with familial B-CLL cases

artículo científico publicado en 2003

Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia

artículo científico publicado en 2003

Acquired RhD mosaicism identifies fibrotic transformation of thrombopoietin receptor-mutated essential thrombocythemia

artículo científico publicado en 2017

Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity

scientific article published on 01 August 2009

Adaptive randomized study of idarubicin and cytarabine alone or with interleukin-11 as induction therapy in patients aged 50 or above with acute myeloid leukemia or high-risk myelodysplastic syndromes

artículo científico publicado en 2005

Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia

artículo científico publicado en 2003

Alemtuzumab: validation of a sensitive and simple enzyme-linked immunosorbent assay.

artículo científico publicado en 2004

An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation

artículo científico publicado en 2007

Anagrelide and imatinib mesylate combination therapy in patients with chronic myeloproliferative disorders

artículo científico publicado en 2003

Angiogenic factors may have a different prognostic role in adult acute lymphoblastic leukemia

artículo científico publicado en 2005

Association of cancer-related symptoms with physiological parameters.

artículo científico publicado en 2002

B-cell clones as early markers for chronic lymphocytic leukemia

artículo científico publicado en 2009

BCR-ABL alternative splicing as a common mechanism for imatinib resistance: evidence from molecular dynamics simulations

artículo científico publicado en 2008

BCR-ABL truncation due to premature translation termination as a mechanism of resistance to kinase inhibitors

artículo científico publicado en 2009

Basis for resistance to imatinib in 16 BCR-ABL mutants as determined using molecular dynamics.

artículo científico publicado en 2009

Bi-clonal disease in patients with chronic lymphocytic leukaemia as detected by analysing IGHV mutation status

artículo científico publicado en 2007

Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival

artículo científico publicado en 2002

C-kit receptor expression in acute leukemias-association with patient and disease characteristics and with outcome

artículo científico publicado en 2004

CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not

artículo científico publicado en 2002

Characteristics and outcome of patients with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia

artículo científico publicado en 2002

Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia

artículo científico publicado en 2005

Chimerism Analysis of Cell-Free DNA in Patients Treated with Hematopoietic Stem Cell Transplantation May Predict Early Relapse in Patients with Hematologic Malignancies

artículo científico publicado en 2016

Chronic lymphocytic leukemia with t(14;18) and trisomy 12

artículo científico publicado en 2002

Circulating CD20 and CD52 in patients with non-Hodgkin's lymphoma or Hodgkin's disease

scientific article published on 01 December 2003

Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance

artículo científico publicado en 2002

Circulating CD33 and its clinical value in acute leukemia

artículo científico publicado en 2010

Circulating CD52 and CD20 levels at end of treatment predict for progression and survival in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab (FCR).

artículo científico publicado en 2009

Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia

artículo científico publicado en 2010

Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lymphoblastic leukemia

artículo científico publicado en 2009

Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia

artículo científico publicado en 2008

Circulating levels and clinical significance of soluble CD40 in patients with hematologic malignancies

artículo científico publicado en 2006

Clinical correlation of circulating heat shock protein 70 in acute leukemia

artículo científico publicado en 2009

Clinical relevance of VEGF receptors 1 and 2 in patients with chronic myelogenous leukemia

scientific article published on 01 July 2003

Clinical relevance of circulating angiogenic factors in patients with non-Hodgkin's lymphoma or Hodgkin's lymphoma

artículo científico publicado en 2004

Clinical relevance of soluble HLA-I and beta2-microglobulin levels in non-Hodgkin's lymphoma and Hodgkin's disease

scientific article published on 20 March 2006

Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell chronic lymphocytic leukemia

scientific article published on 01 April 2003

Clinical relevance of vascular endothelial growth factor receptors 1 and 2 in acute myeloid leukaemia and myelodysplastic syndrome

artículo científico publicado en 2002

Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia

artículo científico publicado en 2017

Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia

scientific article published on 04 December 2006

Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome

artículo científico publicado en 2005

Correlation of MET gene amplification and TP53 mutation with PD-L1 expression in non-small cell lung cancer.

artículo científico publicado en 2018

Correlations between cytogenetic and molecular monitoring among patients with newly diagnosed chronic myeloid leukemia in chronic phase: post hoc analyses of the Rationale and Insight for Gleevec High-Dose Therapy study

artículo científico publicado en 2013

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

artículo científico publicado en 2006

Deep Sequencing of Cell-Free Peripheral Blood DNA as a Reliable Method for Confirming the Diagnosis of Myelodysplastic Syndrome

artículo científico publicado en 2016

Detection of chromosome translocations by bead-based flow cytometry

artículo científico publicado en 2007

Detection of nucleophosmin gene mutations in plasma from patients with acute myeloid leukemia: clinical significance and implications.

artículo científico publicado en 2009

Diagnosis of invasive pulmonary aspergillosis using polymerase chain reaction-based detection of aspergillus in BAL.

artículo científico publicado en 2002

Diagnostic and prognostic scoring system for prostate cancer using urine and plasma biomarkers

artículo científico publicado en 2014

Differences in CD33 intensity between various myeloid neoplasms

artículo científico publicado en 2002

Dysregulation of ubiquitin-proteasome pathway and apolipoprotein A metabolism in sickle cell disease-related pulmonary arterial hypertension

artículo científico publicado en 2013

Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia

artículo científico publicado en 2005

Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia

artículo científico publicado en 2004

Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling

artículo científico publicado en 2011

Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies

artículo científico publicado en 2002

Emerging information on the use of rituximab in chronic lymphocytic leukemia

artículo científico publicado en 2002

Enzymatic activity of circulating proteasomes correlates with clinical behavior in patients with chronic lymphocytic leukemia

artículo científico publicado en 2008

Epidemiology, molecular mycology, and environmental sources of Fusarium infection in patients with cancer

artículo científico publicado en 2002

Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study

artículo científico publicado en 2009

Fluorescence in situ hybridization and K-ras analyses improve diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses

artículo científico publicado en 2011

Fractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte-macrophage-colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GM-CSF in patients wit

artículo científico publicado en 2003

Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies

artículo científico publicado en 2004

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells

article

Gemtuzumab ozogamicin, fludarabine, cytarabine and cyclosporine combination regimen in patients with CD33+ primary resistant or relapsed acute myeloid leukemia

artículo científico publicado en 2003

Gemtuzumab, fludarabine, cytarabine, and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndromes

artículo científico publicado en 2003

He use of the antibodies in the diagnosis of leukemia and lymphoma by flow cytometry

artículo científico publicado en 2007

High-dose imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: high rates of rapid cytogenetic and molecular responses

artículo científico publicado en 2009

Higher detection rate of JAK2 mutation using plasma.

artículo científico publicado en 2008

Imatinib mesylate (STI571) therapy for Philadelphia chromosome-positive chronic myelogenous leukemia in blast phase

artículo científico publicado en 2002

Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results.

artículo científico publicado en 2002

Imatinib mesylate resistance through BCR-ABL independence in chronic myelogenous leukemia

artículo científico publicado en 2004

Immunohistochemistry and alternative FISH testing in breast cancer with HER2 equivocal amplification.

artículo científico publicado en 2018

In vitro activity of dimethylarsinic acid against human leukemia and multiple myeloma cell lines

artículo científico publicado en 2003

Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome

artículo científico publicado en 2003

Increased telomerase activity is associated with shorter survival in patients with chronic phase chronic myeloid leukemia

artículo científico publicado en 2003

Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity ⬇️

artículo científico publicado el 11 de noviembre de 2003

JAK2 Exon 14 Deletion in Patients with Chronic Myeloproliferative Neoplasms ⬇️

artículo científico publicado el 13 de agosto de 2010

Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells

artículo científico publicado en 2009

Less apoptosis in patients with 5q-syndrome than in patients with refractory anemia.

artículo científico publicado en 2002

Liquid-based fluorescence in situ hybridization assay for detection of ERBB2 gene amplification in patients with breast cancer

artículo científico publicado en 2008

MPL mutation profile in JAK2 mutation-negative patients with myeloproliferative disorders.

artículo científico publicado en 2011

Mammalian target of rapamycin as a therapeutic target in leukemia

artículo científico publicado en 2005

Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations

artículo científico publicado en 2009

Molecular basis explanation for imatinib resistance of BCR-ABL due to T315I and P-loop mutations from molecular dynamics simulations

artículo científico publicado en 2008

Molecular differences between small and large cells in patients with chronic lymphocytic leukemia

artículo científico publicado en 2003

Monoclonal antibodies in the treatment of leukemia

artículo científico publicado en 2005

Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial

artículo científico publicado en 2009

Mutation profile of JAK2 transcripts in patients with chronic myeloproliferative neoplasias

artículo científico publicado en 2008

Myelodysplastic syndrome: from morphology to biology.

artículo científico publicado en 2004

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

artículo científico publicado en 2006

PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia

artículo científico publicado en 2007

Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies

artículo científico publicado en 2005

Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse

artículo científico publicado en 2009

Phase I and pharmacokinetic study of a low-clearance, unilamellar liposomal formulation of lurtotecan, a topoisomerase 1 inhibitor, in patients with advanced leukemia

artículo científico publicado en 2004

Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia

artículo científico publicado en 2005

Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies

artículo científico publicado en 2006

Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome

artículo científico publicado en 2004

Phase II study of SU5416, a small molecule vascular endothelial growth factor tyrosine kinase receptor inhibitor, in patients with refractory multiple myeloma

artículo científico publicado en 2004

Phase II study of SU5416--a small-molecule, vascular endothelial growth factor tyrosine-kinase receptor inhibitor--in patients with refractory myeloproliferative diseases

artículo científico publicado en 2003

Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase

artículo científico publicado en 2003

Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy

artículo científico publicado en 2007

Plasma RNA as an alternative to cells for monitoring molecular response in patients with chronic myeloid leukemia

scientific article published on 01 February 2007

Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia

artículo científico publicado en 2003

Plasma thrombopoietin compared with immunoglobulin heavy-chain mutation status as a predictor of survival in chronic lymphocytic leukemia.

artículo científico publicado en 2006

Plasma ubiquitin-proteasome system profile in patients with multiple sclerosis: correlation with clinical features, neuroimaging, and treatment with interferon-beta-1b

artículo científico publicado en 2012

Plasma vascular endothelial growth factor levels have prognostic significance in patients with acute myeloid leukemia but not in patients with myelodysplastic syndromes

artículo científico publicado en 2002

Plasma-based detection of clonality in lymphoid malignancies.

artículo científico publicado en 2009

Plasma-based testing as a new paradigm for clinical testing in hematologic diseases

artículo científico publicado en 2007

Predicting Prostate Biopsy Results Using a Panel of Plasma and Urine Biomarkers Combined in a Scoring System

artículo científico publicado en 2016

Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia Treated With Ibrutinib: Development and Validation of a Four-Factor Prognostic Model

artículo científico publicado en 2020

Presence of restricted killer immunoglobulin-like receptor repertoire and monoclonal T-cell receptor gamma rearrangement as evidence of mixed NK/T-cell differentiation in a subset of sinonasal lymphomas.

artículo científico publicado en 2003

Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients

artículo científico publicado en 2002

Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia

scientific article published on 01 March 2002

Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia

scientific article published on 01 March 2002

Prognostic value of plasma interleukin-6 levels in patients with chronic lymphocytic leukemia

artículo científico publicado en 2002

Proliferation and apoptosis in acute and chronic leukemias and myelodysplastic syndrome

artículo científico publicado en 2002

Prostatectomy-based validation of combined urine and plasma test for predicting high grade prostate cancer

artículo científico publicado en 2018

Proteasome enzymatic activities in plasma as risk stratification of patients with acute myeloid leukemia and advanced-stage myelodysplastic syndrome

artículo científico publicado en 2009

Proteomic-based prediction of clinical behavior in adult acute lymphoblastic leukemia

artículo científico publicado en 2006

Proteomics-based prediction of clinical response in acute myeloid leukemia

artículo científico publicado en 2009

Quantification of intracellular proteins and monitoring therapy using flow cytometry

artículo científico publicado en 2010

Recommendations for the Assessment and Management of Measurable Residual Disease in Adults With Acute Lymphoblastic Leukemia: A Consensus of North American Experts

artículo científico publicado en 2018

Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia ⬇️

artículo científico publicado el 23 de octubre de 2003

Resistance to imatinib in patients with chronic myelogenous leukemia and the splice variant BCR-ABL1(35INS).

artículo científico publicado en 2016

Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders

artículo científico publicado en 2003

SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes

artículo científico publicado en 2003

Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits

artículo científico publicado en 2017

Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome

artículo científico publicado en 2010

Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia

artículo científico publicado en 2003

Soluble vascular endothelial growth factor receptor 1, and not receptor 2, is an independent prognostic factor in acute myeloid leukemia and myelodysplastic syndromes

artículo científico publicado en 2004

Somatic mutations of signaling genes in non-small-cell lung cancer ⬇️

artículo científico publicado el 1 de noviembre de 2010

Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations

artículo científico publicado en 2009

Synonymous Polymorphisms in HOXB13 as a Protective Factor for Prostate Cancer

artículo científico publicado en 2015

Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study

artículo científico publicado en 2010

Tanespimycin with bortezomib: activity in relapsed/refractory patients with multiple myeloma

artículo científico publicado en 2010

Targeted next-generation sequencing of circulating cell-free DNA vs bone marrow in patients with acute myeloid leukemia

scientific article published on 01 April 2020

Telomerase activity is not a prognostic factor in chronic lymphocytic leukemia

artículo científico publicado en 2004

Telomerase activity is prognostic in pediatric patients with acute myeloid leukemia: comparison with adult acute myeloid leukemia

artículo científico publicado en 2003

Thalidomide for patients with recurrent lymphoma

artículo científico publicado en 2004

Thalidomide therapy for myelofibrosis with myeloid metaplasia

scientific article published on 01 May 2006

The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease

artículo científico publicado en 2002

The clinical significance of large cells in bone marrow in patients with chronic lymphocytic leukemia

artículo científico publicado en 2004

The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia

artículo científico publicado en 2007

The prognostic significance of bone marrow levels of neurofibromatosis-1 protein and ras oncogene mutations in patients with acute myeloid leukemia and myelodysplastic syndrome

artículo científico publicado en 2003

The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes

artículo científico publicado en 2008

Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study

artículo científico publicado en 2002

Toward the identification of mesenchymal stem cells in bone marrow and peripheral blood for bone regeneration.

artículo científico publicado en 2008

Trainable immunohistochemical HER2/neu image analysis: a multisite performance study using 260 breast tissue specimens

artículo científico publicado en 2011

Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia

artículo científico publicado en 2003

Ubiquitin-proteasome profiling for enhanced detection of hepatocellular carcinoma in patients with chronic liver disease

artículo científico publicado en 2011

Ubiquitin–proteasome system profiling in acute leukemias and its clinical relevance ⬇️

artículo científico publicado el 15 de octubre de 2010

Use of plasma DNA in detection of loss of heterozygosity in patients with multiple myeloma

artículo científico publicado en 2003

Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors

artículo científico publicado en 2017

Validation of the European Prognostic Index for younger adult patients with acute myeloid leukaemia in first relapse

scientific article published on 01 July 2006

Vascularity, angiogenesis and angiogenic factors in leukemias and myelodysplastic syndromes

artículo científico publicado en 2003

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations

artículo científico publicado en 2017

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