Lista de obras -

Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

artículo científico publicado en 2018

Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA

artículo científico publicado en 2017

Aneuploidy and cancer: from correlation to causation

artículo científico publicado en 2006

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells

artículo científico publicado en 2004

Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

scientific article published on 03 October 2019

Cancer drug resistance: the central role of the karyotype

artículo científico publicado en 2007

Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function

artículo científico publicado en 2009

Centrosome aberrations after nilotinib and imatinib treatment in vitro are associated with mitotic spindle defects and genetic instability

Centrosome aberrations and G1 phase arrest after in vitro and in vivo treatment with the SRC/ABL inhibitor dasatinib

artículo científico publicado en 2008

Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability

artículo científico publicado en 2013

Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene.

artículo científico publicado en 2007

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

artículo científico publicado en 2015

Comprehensive mutational profiling in advanced systemic mastocytosis

artículo científico publicado en 2013

Correction: High-risk additional chromosomal abnormalities at low blast counts herald death by CML

scientific article published on 10 September 2020

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia

artículo científico publicado en 2020

DNA microarray-based detection and identification of fungal pathogens in clinical samples from neutropenic patients

artículo científico publicado en 2007

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

artículo científico publicado en 2013

Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV.

artículo científico publicado en 2018

Detection of centrosome aberrations in disease-unrelated cells from patients with tumor treated with tyrosine kinase inhibitors

artículo científico publicado en 2010

Diagnostic challenges in the work up of hypereosinophilia: pitfalls in bone marrow core biopsy interpretation.

artículo científico publicado en 2016

Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials

Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial.

artículo científico publicado en 2018

Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib

artículo científico publicado en 2014

Dynamics of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during dasatinib therapy of chronic myeloid leukemia patients after imatinib failure

article

Effect of ABCG2, OCT1, and ABCB1 (MDR1) Gene Expression on Treatment-Free Remission in a EURO-SKI Subtrial.

artículo científico publicado en 2018

Effects of imatinib mesylate in patients with polycythemia vera: results of a phase II study

artículo científico publicado en 2013

Equivalence of BCR-ABL transcript levels with complete cytogenetic remission in patients with chronic myeloid leukemia in chronic phase

artículo científico publicado en 2014

Functional imaging with dual-energy computed tomography for supplementary non-invasive assessment of mast cell burden in systemic mastocytosis

artículo científico publicado en 2022

Fusion of PDGFRB to MPRIP, CPSF6, and GOLGB1 in three patients with eosinophilia-associated myeloproliferative neoplasms.

artículo científico publicado en 2015

Genomic instability in context of the chromosomal theory.

artículo científico publicado en 2008

HERV-E-mediated modulation of PLA2G4A transcription in urothelial carcinoma

artículo científico publicado en 2012

High-risk additional chromosomal abnormalities at low blast counts herald death by CML

scientific article published on 07 May 2020

Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms

artículo científico publicado en 2014

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV

article

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase

artículo científico publicado en 2017

Immunofluorescence Microscopy of γH2AX and 53BP1 for Analyzing the Formation and Repair of DNA Double-strand Breaks

artículo científico publicado en 2017

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.

artículo científico publicado en 2011

Impact of centralized evaluation of bone marrow histology in systemic mastocytosis.

artículo científico publicado en 2016

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML study IV.

artículo científico publicado en 2015

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML.

artículo científico publicado en 2015

Importance of adequate diagnostic work-up for correct diagnosis of advanced systemic mastocytosis

artículo científico publicado en 2020

Incidence and prognostic impact of cytogenetic aberrations in patients with systemic mastocytosis

artículo científico publicado en 2018

Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias

artículo científico publicado en 2017

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

artículo científico publicado en 2018

Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy ⬇️

artículo científico publicado el 1 de mayo de 2003

KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

scientific article published on 11 January 2019

KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance

artículo científico publicado en 2015

Leukocyte DNA damage after reduced and conventional absorbed radiation doses using 3rd generation dual-source CT technology

artículo científico publicado en 2016

Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes

artículo científico publicado en 2014

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

artículo científico publicado en 2019

Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay

artículo científico publicado en 2015

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

artículo científico publicado en 2016

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.

artículo científico publicado en 2014

Orders of Magnitude Change in Phenotype Rate Caused by Mutation.

artículo científico publicado en 2007

Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers

artículo científico publicado en 2017

Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes

scientific article published on 12 April 2020

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

artículo científico publicado en 2012

Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study

artículo científico publicado en 2008

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients

artículo científico publicado en 2020

Smoking Increases Transcription of Human Endogenous Retroviruses in a Newly Established in Vitro Cell Model and in Normal Urothelium ⬇️

artículo científico publicado el 1 de agosto de 2010

Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea

artículo científico publicado en 2002

Specific clones of spontaneously evolving karyotypes generate individuality of cancers

artículo científico publicado en 2008

The KIT D816V expressed allele burden for diagnosis and disease monitoring of systemic mastocytosis.

artículo científico publicado en 2013

The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib

artículo científico publicado en 2024

The benefit of quality control charts (QCC) for routine quantitative BCR-ABL1 monitoring in chronic myeloid leukemia.

artículo científico publicado en 2018

The chromosomal basis of cancer.

artículo científico publicado en 2005

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm

artículo científico publicado en 2017

The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib

artículo científico publicado en 2012

Treatment-free remission in FIP1L1-PDGFRA-positive myeloid/lymphoid neoplasms with eosinophilia after imatinib discontinuation

scientific article published on 01 February 2020

Urine from current smokers induces centrosome aberrations and spindle defects in vitro in nonmalignant human cell lines ⬇️

artículo científico publicado el 1 de diciembre de 2010

Variable transcriptional activity of endogenous retroviruses in human breast cancer

scientific article (publication date: February 2008)

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.

artículo científico publicado en 2013

c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia

artículo científico publicado en 2016

Lista de obras de

Accumulation of DNA damage and alteration of the DNA damage response in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA

Aneuploidy and cancer: from correlation to causation

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells

Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies

Cancer drug resistance: the central role of the karyotype

Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function

Centrosome aberrations after nilotinib and imatinib treatment in vitro are associated with mitotic spindle defects and genetic instability

Centrosome aberrations and G1 phase arrest after in vitro and in vivo treatment with the SRC/ABL inhibitor dasatinib

Centrosome aberrations in bone marrow cells from patients with myelodysplastic syndromes correlate with chromosomal instability

Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene.

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

Comprehensive mutational profiling in advanced systemic mastocytosis

Correction: High-risk additional chromosomal abnormalities at low blast counts herald death by CML

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia

DNA microarray-based detection and identification of fungal pathogens in clinical samples from neutropenic patients

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV.

Detection of centrosome aberrations in disease-unrelated cells from patients with tumor treated with tyrosine kinase inhibitors

Diagnostic challenges in the work up of hypereosinophilia: pitfalls in bone marrow core biopsy interpretation.

Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials

Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial.

Distinct characteristics of e13a2 versus e14a2 BCR-ABL1 driven chronic myeloid leukemia under first-line therapy with imatinib

Dynamics of cytogenetic aberrations in Philadelphia chromosome positive and negative hematopoiesis during dasatinib therapy of chronic myeloid leukemia patients after imatinib failure

Effect of ABCG2, OCT1, and ABCB1 (MDR1) Gene Expression on Treatment-Free Remission in a EURO-SKI Subtrial.

Effects of imatinib mesylate in patients with polycythemia vera: results of a phase II study

Equivalence of BCR-ABL transcript levels with complete cytogenetic remission in patients with chronic myeloid leukemia in chronic phase

Functional imaging with dual-energy computed tomography for supplementary non-invasive assessment of mast cell burden in systemic mastocytosis

Fusion of PDGFRB to MPRIP, CPSF6, and GOLGB1 in three patients with eosinophilia-associated myeloproliferative neoplasms.

Genomic instability in context of the chromosomal theory.

HERV-E-mediated modulation of PLA2G4A transcription in urothelial carcinoma

High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV

Imatinib in myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRB in chronic or blast phase

Immunofluorescence Microscopy of γH2AX and 53BP1 for Analyzing the Formation and Repair of DNA Double-strand Breaks

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.

Impact of centralized evaluation of bone marrow histology in systemic mastocytosis.

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML study IV.

Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML.

Importance of adequate diagnostic work-up for correct diagnosis of advanced systemic mastocytosis

Incidence and prognostic impact of cytogenetic aberrations in patients with systemic mastocytosis

Increase of DNA damage and alteration of the DNA damage response in myelodysplastic syndromes and acute myeloid leukemias

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy ⬇️

KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance

Leukocyte DNA damage after reduced and conventional absorbed radiation doses using 3rd generation dual-source CT technology

Limited duration of complete remission on ruxolitinib in myeloid neoplasms with PCM1-JAK2 and BCR-JAK2 fusion genes

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay

Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.

Orders of Magnitude Change in Phenotype Rate Caused by Mutation.

Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers

Response to tyrosine kinase inhibitors in myeloid neoplasms associated with PCM1-JAK2, BCR-JAK2 and ETV6-ABL1 fusion genes

SNP array analysis of acute promyelocytic leukemia may be of prognostic relevance and identifies a potential high risk group with recurrent deletions on chromosomal subband 1q31.3.

Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients

Smoking Increases Transcription of Human Endogenous Retroviruses in a Newly Established in Vitro Cell Model and in Normal Urothelium ⬇️

Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea

Specific clones of spontaneously evolving karyotypes generate individuality of cancers

The KIT D816V expressed allele burden for diagnosis and disease monitoring of systemic mastocytosis.

The SNP rs460089 in the gene promoter of the drug transporter OCTN1 has prognostic value for treatment-free remission in chronic myeloid leukemia patients treated with imatinib

The benefit of quality control charts (QCC) for routine quantitative BCR-ABL1 monitoring in chronic myeloid leukemia.

The chromosomal basis of cancer.

The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm

The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib

Treatment-free remission in FIP1L1-PDGFRA-positive myeloid/lymphoid neoplasms with eosinophilia after imatinib discontinuation

Urine from current smokers induces centrosome aberrations and spindle defects in vitro in nonmalignant human cell lines ⬇️

Variable transcriptional activity of endogenous retroviruses in human breast cancer

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV.

c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia