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5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).

artículo científico publicado en 2006

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth Via Novel RNA- and ATP-Directed Mechanisms: A Novel Therapeutic Approach for AML ⬇️

artículo científico publicado en 2015

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth and Synergizes with the BCL-2 Inhibitor Venetoclax (ABT-199) ⬇️

scholarly article

8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia

scientific article published on 15 February 2019

A 75-year-old woman with thoracic spinal cord compression and chloroma (granulocytic sarcoma)

artículo científico publicado en 2012

A Combined Molecular and Clinical Prognostic Index For Relapse and Survival In Cytogenetically Normal AML (PINA) ⬇️

scholarly article

A LC-MS/MS method for the analysis of intracellular nucleoside triphosphate levels

artículo científico publicado en 2009

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

artículo científico publicado en 2005

A Multivariate Clinical and Economic Model for Predicting Risk-Based Costs of Care for Acute Leukemia (AL) Patients (Pts) Undergoing Allogeneic Hematopoietic Cell Transplant (HCT) ⬇️

scholarly article

A Novel Regimen for Acute Myeloid Leukemia with MLL Partial Tandem Duplication: Results of a Phase 1 Study NCI 8485 ⬇️

artículo científico publicado en 2016

A Novel Therapeutic Approach In Acute Myeloid Leukemia (AML): In Vivo Preclinical Pharmacokinetic (PK), Pharmacodynamic (PD) and Antileukemia Activities Of Synthetic 2’-O-Methylphosphorothioate Mir-29b ⬇️

artículo científico publicado en 2013

A Phase I Trial of Total Marrow and Lymphoid Irradiation (TMLI)-Based Transplant Conditioning in Patients (Pts) with Relapsed/Refractory Acute Leukemia ⬇️

artículo científico publicado en 2015

A Scalable, Flexible Workflow for MethylCap-Seq Data Analysis

artículo científico publicado en 2011

A Specific Picomolar Hybridization-Based ELISA Assay for the Determination of Phosphorothioate Oligonucleotides in Plasma and Cellular Matrices

artículo científico publicado en 2006

A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults

artículo científico publicado en 2014

A novel Raji-Burkitt's lymphoma model for preclinical and mechanistic evaluation of CD52-targeted immunotherapeutic agents

artículo científico publicado en 2008

A novel liposomal formulation of flavopiridol

artículo científico publicado en 2008

A novel regimen for relapsed/refractory adult acute myeloid leukemia using a KMT2A partial tandem duplication targeted therapy: results of phase 1 study NCI 8485.

artículo científico publicado en 2018

A novel ultrasensitive hybridization-based ELISA method for 2-methoxyphosphorothiolate microRNAs and its in vitro and in vivo application

artículo científico publicado en 2010

A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403

scientific article published on 18 January 2019

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

artículo científico publicado en 2004

A phase 2 study incorporating sorafenib into the chemotherapy for older adults with -mutated acute myeloid leukemia: CALGB 11001

article published in 2017

A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia

artículo científico publicado en 2008

A phase II study of continuous infusion homoharringtonine and cytarabine in newly diagnosed patients with chronic myeloid leukemia: CALGB study 19804.

artículo científico publicado en 2008

A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

artículo científico publicado en 2010

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

artículo científico publicado en 2011

Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation

artículo científico publicado en 2012

Abnormal Cytogenetics at Date of Morphologic Complete Remission Predicts Short Overall and Disease-Free Survival, and Higher Relapse Rate in Adult Acute Myeloid Leukemia: Results From Cancer and Leukemia Group B Study 8461

article

Acute Lymphocytic Leukemia in the Latin American Population ⬇️

scholarly article

Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology

artículo científico publicado en 2017

Acute Myeloid Leukemia: Biologic, Prognostic, and Therapeutic Insights

artículo científico publicado en 2016

Acute myeloid leukemia, version 2.2013.

artículo científico publicado en 2013

Acute myeloid leukemia. Introduction

artículo científico publicado en 2008

Addition of Sorafenib to Chemotherapy Improves the Overall Survival of Older Adults with FLT3-ITD Mutated Acute Myeloid Leukemia (AML) (Alliance C11001) ⬇️

artículo científico publicado en 2015

Addition of infliximab to standard acute graft-versus-host disease prophylaxis following allogeneic peripheral blood cell transplantation

artículo científico publicado en 2008

Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia

artículo científico publicado en 2008

Adverse Prognostic Impact of GAS6 Expression in De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) (CALGB 8461, 9665, 20202; Alliance) ⬇️

artículo científico publicado en 2012

Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study

artículo científico publicado en 2006

Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2012

Aging in a Relativistic Biological Space-Time.

artículo científico publicado en 2018

Aging in a relativistic biological space-time

Alemtuzumab Consolidation Does Not Improve Outcome for CLL Patients with High Risk Genomic Features on Successive CALGB Trials. ⬇️

artículo científico publicado en 2011

Allogeneic Hematopoietic Cell Transplantation (HCT) Vs. Non-HCT Consolidation Therapies in Acute Myeloid Leukemia (AML) Patients 60-75 Years of Age in First Complete Remission (CR1): An Alliance (A151509), SWOG, ECOG-ACRIN and CIBMTR Study ⬇️

scholarly article

Allogeneic Hematopoietic Cell Transplantation Outcomes in Patients Carrying Isocitrate Dehydrogenase Mutations.

artículo científico publicado en 2019

Allogeneic Stem Cell Transplantation for Patients with Chemo-Refractory or Progressive Aggressive Non-Hodgkin’s Lymphomas. ⬇️

artículo científico publicado en 2008

Allogeneic hematopoietic cell transplantation compared to chemotherapy consolidation in older acute myeloid leukemia (AML) patients 60-75 years in first complete remission (CR1): an alliance (A151509), SWOG, ECOG-ACRIN, and CIBMTR study

artículo científico publicado en 2019

Allogeneic stem cell transplantation for patients with relapsed chemorefractory aggressive non-hodgkin lymphomas

artículo científico publicado en 2009

An 86-Probe Gene Expression Signature Can Predict Survival in AML with Normal Karyotype Independently of FLT3 ITD and NPM1 Mutation Status - A Collaborative Study from the AMLCG and CALGB Study Groups. ⬇️

artículo científico publicado en 2007

An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2008

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

artículo científico publicado en 2013

Anti-Leukemic Activity of the CRM1 Inhibitor KPT-330 in Advanced CML and Ph+ ALL ⬇️

artículo científico publicado en 2012

Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia

artículo científico publicado en 2017

Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia

artículo científico publicado en 2010

Association of leukemia genetics with response to venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

scientific article published on 10 July 2019

Autologous transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia achieves outcomes similar to allogeneic transplantation: results of CALGB Study 10001 (Alliance).

artículo científico publicado en 2013

BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2010

BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study

artículo científico publicado en 2003

BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2A-Controlled Jak2 Activation and Is Sensitive to FTY720 Treatment ⬇️

artículo científico publicado en 2010

BCR/ABL Dosage Hierarchically and Temporally Influences hnRNP A1, hnRNP K and hnRNP E2 Expression in Hematopoietic Stem and Progenitor Cells. ⬇️

artículo científico publicado en 2009

BCR/ABL Post-Translationally Enhances hnRNP E2 Expression and Translation-Inhibitory Function through the Activation of ERK1/2 Mitogen-Activated Protein Kinases. ⬇️

artículo científico publicado en 2005

Bioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromes

artículo científico publicado en 2005

Biochemical Modulation of Aracytidine (Ara-C) Effects by GTI-2040, a Ribonucleotide Reductase Inhibitor, in K562 Human Leukemia Cells ⬇️

artículo científico publicado el 30 de diciembre de 2010

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.

artículo científico publicado en 2018

Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502.

artículo científico publicado en 2012

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia

artículo científico publicado en 2007

Bortezomib-Induced Down-Regulation of KIT Is Mediated by Inhibition of Sp1 and NF-kB in AML1/ETO-Positive Cells. ⬇️

artículo científico publicado en 2006

CAR22/19 Cocktail Therapy for Patients with Refractory/Relapsed B-Cell Malignancies ⬇️

artículo científico publicado en 2018

CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice.

artículo científico publicado en 2016

CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma

artículo científico publicado en 2016

CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia

artículo científico publicado en 2015

CD84: A Potential Novel Therapeutic Target in the Multiple Myeloma Microenvironment ⬇️

scholarly article

CD94 defines phenotypically and functionally distinct mouse NK cell subsets

artículo científico publicado en 2009

CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets

artículo científico publicado en 2009

Cell lineage analysis of acute leukemia relapse uncovers the role of replication-rate heterogeneity and microsatellite instability.

artículo científico publicado en 2012

Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia

artículo científico publicado en 2005

Challenges for Conducting Clinical Trials Evaluating Maintenance Chemotherapy In Acute Myeloid Leukemia (AML): a Cancer and Leukemia Group B (CALGB) Study ⬇️

artículo científico publicado en 2010

Characterization and quantification of Bcl-2 antisense G3139 and metabolites in plasma and urine by ion-pair reversed phase HPLC coupled with electrospray ion-trap mass spectrometry

artículo científico publicado en 2005

Characterization of HDACI OSU42 as a Novel Histone Deacetylase Inhibitor in AML Cell Lines. ⬇️

artículo científico publicado en 2006

Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method

artículo científico publicado en 2006

Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specific and sensitive LC-MS/MS method

artículo científico publicado en 2007

Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development.

artículo científico publicado en 2003

Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2011

Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines

artículo científico publicado en 2005

Chipping away at the chip bias: RNA degradation in microarray analysis

artículo científico publicado en 2003

Circulating Mir-16 and Mir-25 As New Prognosticators For Multiple Myeloma ⬇️

scholarly article

Clinical Outcomes of MDS Patients Who Were Allogeneic Hematopoietic Stem Cell Transplant Candidates but Did Not Proceed with Transplantation ⬇️

artículo científico publicado en 2018

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia

artículo científico publicado en 2012

Clinical characteristics and outcomes in patients with acute promyelocytic leukaemia and hyperleucocytosis

artículo científico publicado en 2014

Clinical experience with venetoclax and hypomethylating agents (HMA) in patients with newly diagnosed and relapsed or refractory KMT2A-Rearranged acute myeloid leukemia (AML)

artículo científico publicado en 2022

Clinical impact of ABL1 kinase domain mutations and IKZF1 deletion in adults under age 60 with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL): molecular analysis of CALGB (Alliance) 10001 and 9665.

artículo científico publicado en 2016

Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2011

Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: a concise review

artículo científico publicado en 2007

Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?

artículo científico publicado en 2006

Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine

artículo científico publicado en 2010

Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients

artículo científico publicado en 2013

Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801

artículo científico publicado en 2020

Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2014

Comparison Of Deep Sequencing and Allele-Specific Oligonucleotide PCR Methods For MRD Quantitation In Acute Lymphoblastic Leukemia and Mantle Cell Lymphoma: CALGB 10403 and CALGB 59909 (Alliance) ⬇️

artículo científico publicado en 2013

Comparison of reduced-intensity hematopoietic cell transplantation with chemotherapy in patients age 60-70 years with acute myelogenous leukemia in first remission

artículo científico publicado en 2011

Copper-64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma

artículo científico publicado en 2018

Core binding factor (CBF) acute myeloid leukemia: is molecular monitoring by RT-PCR useful clinically?

artículo científico publicado en 2003

Core-binding factor acute myeloid leukemia with inv(16): Older age and high white blood cell count are risk factors for treatment failure

artículo científico publicado en 2020

Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit)

Correction: Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status.

artículo científico publicado en 2013

Correction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation

artículo científico publicado en 2017

Correlates of resistance and relapse during blinatumomab therapy for relapsed/refractory acute lymphoblastic leukemia

artículo científico publicado en 2017

Curcumin is a potent DNA hypomethylation agent

artículo científico publicado en 2008

Cytogenetics Does Not Impact Outcomes in Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation

artículo científico publicado en 2016

Cytokine Gene Polymorphisms Are Associated with Disease Response to Blinatumomab in Patients with B-Cell Acute Lymphoblastic Leukemia ⬇️

scholarly article

DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

artículo científico publicado en 2008

Decitabine Priming Enhances The Antileukemic Effects Of The Selective Inhibitor Of Nuclear Export (SINE) CRM1/XPO1 Antagonist (Selinexor) In Acute Myeloid Leukemia (AML) ⬇️

scholarly article

Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia

artículo científico publicado en 2015

Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing

artículo científico publicado en 2009

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

artículo científico publicado en 2003

Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines

artículo científico publicado en 2003

Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma

artículo científico publicado en 2005

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

artículo científico publicado en 2016

Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons

artículo científico publicado en 2013

Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells

artículo científico publicado en 2012

Dicer Ablations in Bone Marrow Niche Impair Hematopoietic Progenitor/Stem Cells and Induce Myelodysplasia in Young Mice but Are Dispensable for Adult Hematopoiesis ⬇️

scholarly article

Differential Clinical Impact Of Gene Mutations and Their Combinations In Primary Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) ⬇️

artículo científico publicado en 2013

Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry

artículo científico publicado en 2004

Disulfide-linked liposomes: effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139.

artículo científico publicado en 2010

Dose escalation of lenalidomide in relapsed or refractory acute leukemias

artículo científico publicado en 2010

Dose intensification of daunorubicin and cytarabine during treatment of adult acute lymphoblastic leukemia: results of Cancer and Leukemia Group B Study 19802.

artículo científico publicado en 2012

Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target? ⬇️

artículo científico publicado en 2018

Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia

artículo científico publicado en 2005

EGFL7 Antagonizes NOTCH Signaling, Stimulates Blast Proliferation and Confers Poor Prognosis in Cytogenetically-Normal Acute Myeloid Leukemia (CN-AML) ⬇️

scholarly article

Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis

scientific article published on 22 February 2019

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells

artículo científico publicado en 2014

Effect of Vancomycin-Resistance Enterococci Colonization Status Prior to Allogeneic Hematopoietic Cell Transplantation on Transplant Outcomes: A Single Center Retrospective Experience ⬇️

artículo científico publicado en 2018

Efficacy of FLT3 and IDH1/2 inhibitors in patients with acute myeloid leukemia previously treated with venetoclax

scientific article published in 2022

Efficacy of the combination of venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia

scholarly article by Ibrahim Aldoss et al published September 2018 in Haematologica

Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes.

artículo científico publicado en 2006

Efficient delivery of antisense oligodeoxyribonucleotide g3139 by human serum albumin-coated liposomes

artículo científico publicado en 2009

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

artículo científico publicado en 2005

Emerging diagnostic and therapeutic approaches in core binding factor acute myeloid leukaemia

artículo científico publicado en 2015

Enrichment-based DNA methylation analysis using next-generation sequencing: sample exclusion, estimating changes in global methylation, and the contribution of replicate lanes

artículo científico publicado en 2012

Enzyme kinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase

artículo científico publicado en 2008

Epigenetic Targeting Via Transcriptional Inhibition of DNA Methyltransferase: a Phase I Study of Bortezomib in Combination with 5-Azacytidine in Adults with Relapsed or Refractory Acute Myeloid Leukemia (AML). ⬇️

artículo científico publicado en 2009

Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia

artículo científico publicado en 2009

Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia

artículo científico publicado en 2008

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway

artículo científico publicado en 2012

Epigenetics in acute myeloid leukemia

artículo científico publicado en 2008

Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score

artículo científico publicado en 2013

Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease

scientific article published on October 2013

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status

artículo científico publicado en 2013

Event-Free Survival As a Surrogate Endpoint for Overall Survival in Previously Untreated Acute Myeloid Leukemia: An Individual Patient-Level Analysis of Multiple Randomized Trials (Alliance A151614) ⬇️

artículo científico publicado en 2018

Exosomes-driven lipolysis and bone marrow niche remodeling supports leukemia expansion

artículo científico publicado en 2020

Expression and prognostic impact of lncRNAs in acute myeloid leukemia

artículo científico publicado en 2014

Expression of an Oncogenic ERG isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia ⬇️

artículo científico publicado en 2015

FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

artículo científico publicado en 2008

FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2010

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

artículo científico publicado en 2007

Favorable Outcomes for Older Adolescents and Young Adults (AYA) with Acute Lymphoblastic Leukemia (ALL): Early Results of U.S. Intergroup Trial C10403 ⬇️

scholarly article

Favorable impact of allogeneic stem cell transplantation in patients with therapy-related myelodysplasia regardless of TP53 mutational status

artículo científico publicado en 2017

Favorable outcomes for allogeneic hematopoietic cell transplantation in elderly patients with NPM1-mutated and FLT3-ITD-negative acute myeloid leukemia

scientific article published on 14 May 2019

Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study

artículo científico publicado en 2010

Fever and neutropenia clinical practice guidelines.

artículo científico publicado en 2004

Final Results of a Dose Escalation Study of Flavopiridol in Acute Leukemias Using a Novel Treatment Schedule. ⬇️

artículo científico publicado en 2007

Functional implications of microRNAs in acute myeloid leukemia by integrating microRNA and messenger RNA expression profiling

artículo científico publicado en 2011

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy

artículo científico publicado en 2013

Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma

scientific article published on 22 January 2014

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia

artículo científico publicado en 2013

Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia

artículo científico publicado en 2012

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

artículo científico publicado en 2016

Genomic and Proteomic Analysis of Primary Chemoresistance and Induction Failure in Acute Myeloid Leukemia ⬇️

scholarly article

Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia

artículo científico publicado en 2016

Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

artículo científico publicado en 2005

HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML

artículo científico publicado en 2020

HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation

artículo científico publicado en 2015

HDAC8 Regulates Long-Term Hematopoietic Stem Cell Quiescence and Maintenance ⬇️

artículo científico publicado en 2016

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

artículo científico publicado en 2017

Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia

artículo científico publicado en 2012

Heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells

artículo científico publicado en 2016

High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CAL

artículo científico publicado en 2008

High Expression Levels of theETS-Related Gene,ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

article

High Frequency and Poor Outcome of Ph-like Acute Lymphoblastic Leukemia in Adults ⬇️

scholarly article

High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults

artículo científico publicado en 2016

High disease burden is associated with poor outcomes for patients with acute myeloid leukemia not in remission who undergo unrelated donor cell transplantation.

artículo científico publicado en 2006

High dose cytarabine plus gemtuzumab ozogamicin for patients with relapsed or refractory acute myeloid leukemia: Cancer and Leukemia Group B study 19902.

artículo científico publicado en 2010

High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia

artículo científico publicado en 2011

Histone H4 N-terminal acetylation in Kasumi-1 cells treated with depsipeptide determined by acetic acid-urea polyacrylamide gel electrophoresis, amino acid coded mass tagging, and mass spectrometry

artículo científico publicado en 2007

Histone H4 acetylation dynamics determined by stable isotope labeling with amino acids in cell culture and mass spectrometry

artículo científico publicado en 2006

Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortality

artículo científico publicado en 2007

Hypomethylating agents in combination with venetoclax for acute myeloid leukemia: Update on clinical trial data and practical considerations for use

scientific article published on 13 December 2018

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2010

Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study

artículo científico publicado en 2013

Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor

artículo científico publicado en 2016

Identification of medium-sized copy number alterations in whole-genome sequencing

artículo científico publicado en 2014

Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis

artículo científico publicado en 2007

Identification of the Histone Deacetylase Inhibitor (HDACi), AR-42, as a Novel Anti-Leukemia Stem Cell Agent in Acute Myeloid Leukemia (AML). ⬇️

artículo científico publicado en 2009

Identification of thiols and glutathione conjugates of depsipeptide FK228 (FR901228), a novel histone protein deacetylase inhibitor, in the blood

artículo científico publicado en 2003

Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64-labeled daratumumab

artículo científico publicado en 2020

Immune Mediated Mechanisms of Resistance to Daratumumab ⬇️

artículo científico publicado en 2018

Impact of DNMT3A mutations on Clinical Response to the Hypomethylating Agent Decitabine in Older Patients (pts) with Acute Myeloid Leukemia (AML) ⬇️

scholarly article

Impact of NPM1/FLT3-ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

artículo científico publicado en 2020

Impact of molecular prognostic factors in cytogenetically normal acute myeloid leukemia at diagnosis and relapse

artículo científico publicado en 2011

Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.

artículo científico publicado en 2014

Improved nonrelapse mortality and infection rate with lower dose of antithymocyte globulin in patients undergoing reduced-intensity conditioning allogeneic transplantation for hematologic malignancies

scientific article published on September 2009

In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline

artículo científico publicado en 2013

In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation

artículo científico publicado en 2013

In vivo quantification of active decitabine-triphosphate metabolite: a novel pharmacoanalytical endpoint for optimization of hypomethylating therapy in acute myeloid leukemia

artículo científico publicado en 2012

Incidence and Risk Factors of CMV Reactivation after Haploidentical Hematopoietic Cell Transplantation Using High-Dose Post-Transplant Cyclophosphamide - Possible Role of Donor KIR Genotypes ⬇️

artículo científico publicado en 2018

Incidence of Extramedullary Relapse of Acute Myeloid Leukemia Following Transplantation with Busulfan-Based Conditioning Regimens. ⬇️

scholarly article

Increased Expression Of IL-15 Promotes Cutaneous T-Cell Lymphomagenesis Via The Upregulation Of Histone Deacetylases: Evidence For Successful Preclinical Targeting ⬇️

artículo científico publicado en 2013

Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study

artículo científico publicado en 2006

Induced Apoptosis Investigation in Wild-type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single-cell qRT-PCR.

artículo científico publicado en 2016

Influence of donor KIR genotypes on reduced relapse risk in acute myelogenous leukemia after hematopoietic stem cell transplantation in patients with CMV reactivation

artículo científico publicado en 2019

Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target

artículo científico publicado en 2013

Initial Results Of a Phase II Trial Of Sorafenib Plus Standard Induction In Older Adults With Mutant FLT3 Acute Myeloid Leukemia (AML) (Alliance trial C11001) ⬇️

artículo científico publicado en 2013

Intensive induction is effective in selected octogenarian acute myeloid leukemia patients: prognostic significance of karyotype and selected molecular markers used in the European LeukemiaNet classification

artículo científico publicado en 2013

Interleukin-15 Is a Proto-Oncogene In Acute Large Granular Lymphocyte Leukemia ⬇️

scholarly article

Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

artículo científico publicado en 2005

Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway

artículo científico publicado en 2014

Invasive fungal infections in acute myeloid leukemia treated with venetoclax and hypomethylating agents

scientific article published on 01 December 2019

Iron Overload is Associated with Delayed Engraftment and Increased Non-Relapse Mortality in Recipients of Umbilical Cord Blood Hematopoietic Cell Transplantation

artículo científico publicado en 2020

Knockdown (KD) of Mir-126 Expression Enhances Tyrosine Kinase Inhibitor (TKI)-Mediated Targeting of Chronic Myelogenous Leukemia (CML) Stem Cells ⬇️

scholarly article

Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

artículo científico publicado en 2008

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia

artículo científico publicado en 2012

Leukocytoreduction for acute leukemia

artículo científico publicado en 2002

Liquid chromatography mass spectrometry profiling of histones

artículo científico publicado en 2007

Long-Term Outcomes of Patients with Acute Myelogenous Leukemia Treated with Myeloablative Fractionated Total Body Irradiation TBI-Based Conditioning with a Tacrolimus- and Sirolimus-Based Graft-versus-Host Disease Prophylaxis Regimen: 6-Year Follow-

artículo científico publicado en 2019

Long-term Outcomes of Allogeneic Hematopoietic Cell transplantation with Fludarabine and Melphalan Conditioning and Tacrolimus/Sirolimus as GVHD prophylaxis in Patients with Acute Lymphoblastic Leukemia

artículo científico publicado en 2020

Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study

artículo científico publicado en 2007

Loss of C/EBP alpha and favorable prognosis of acute myeloid leukemias: a biological paradox

artículo científico publicado en 2004

Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults

artículo científico publicado en 2013

Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2011

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

artículo científico publicado en 2017

MIPSS70+ V2.0 and Revised Cytogenetics Changes Predict Outcomes of Allogeneic Transplantation with Fludarabine and Melphalan Conditioning in Patients with Myelofibrosis ⬇️

artículo científico publicado en 2018

MIPSS70+ v2.0 predicts long-term survival in myelofibrosis after allogeneic HCT with the Flu/Mel conditioning regimen

MODELING and Targeting ERG-INDUCED Acute MYELOID LEUKEMIA (AML). ⬇️

artículo científico publicado en 2009

Management of patients with cytogenetically normal acute myeloid leukemia who have neither favorable nor unfavorable markers

artículo científico

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma

artículo científico publicado en 2016

Melphalan-Based Reduced Intensity Conditioning is Associated with Favorable Disease Control and Acceptable Toxicities in Patients Older Than 70 with Hematologic Malignancies Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

artículo científico publicado en 2018

Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry

scientific article published on January 2006

Methods for high-throughput MethylCap-Seq data analysis

artículo científico publicado en 2012

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

artículo científico publicado en 2015

MiR-3151, a Novel MicroRNA Embedded in BAALC, Is Only Weakly Co-Expressed with Its Host Gene and Independently Impacts on the Clinical Outcome of Older Patients (Pts) with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) ⬇️

artículo científico publicado en 2011

MiRNA-29b Targets MCL-1 and Is Down-Regulated in Chemotherapy-Resistant Acute Myeloid Leukemia (AML). ⬇️

artículo científico publicado en 2007

MicroRNA (miRNA)-29b Targets DNMT3A and B and Induces Re-Expression of the Hypermethylated ESR1 and p15 Genes in Acute Myeloid Leukemia (AML). ⬇️

scholarly article

MicroRNA 29b functions in acute myeloid leukemia

artículo científico publicado en 2009

MicroRNA expression in acute myeloid leukemia

artículo científico publicado en 2009

MicroRNA expression in cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2008

MicroRNA expression profiling in acute myeloid and chronic lymphocytic leukaemias

artículo científico publicado en 2009

MicroRNA fingerprints during human megakaryocytopoiesis

artículo científico publicado en 2006

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

artículo científico publicado en 2008

MicroRNA-181a Targets TEL/AML1 Expression and Impairs Cell Proliferation in t(12;21) Acute Lymphocytic Leukemia (ALL) Cells. ⬇️

artículo científico publicado en 2009

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

artículo científico publicado en 2007

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

artículo científico publicado en 2009

Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial

artículo científico publicado en 2020

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

artículo científico publicado en 2017

Midostaurin, bortezomib and MEC in relapsed/refractory acute myeloid leukemia

artículo científico publicado en 2016

Milatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies

scientific article published on 03 December 2012

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

scientific journal article

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

artículo científico publicado en 2006

Modulation of DNA methylation by a sesquiterpene lactone parthenolide

artículo científico publicado en 2009

Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications

artículo científico publicado en 2011

Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics

artículo científico publicado en 2005

Molecular prognostic factors in cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2012

Molecular signatures in acute myeloid leukemia.

artículo científico publicado en 2009

More options for older patients with acute myeloid leukemia: venetoclax in combination with low dose cytarabine

scientific article published on 01 October 2019

Multiplexed Digital Quantification of mRNA Abundance: a Highly Reproducible, PCR–independent Assessment of BAALC, ERG, and MN1 mRNA Levels in Acute Myeloid Leukemia (AML) Bone Marrow (BM) and Peripheral Blood (PB) Samples. ⬇️

scholarly article

Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2010

Myeloid cell-targeted miR-146a mimic inhibits NF-κB-driven inflammation and leukemia progression in vivo

artículo científico publicado en 2020

NCCN Clinical Practice Guidelines Acute myeloid leukemia

artículo científico publicado en 2012

NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

artículo científico publicado en 2011

NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human ⬇️

artículo científico publicado el 1 de abril de 2011

NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation

scientific article published on 28 February 2014

New approaches in acute myeloid leukemia

artículo científico publicado en 2008

New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461.

artículo científico publicado en 2012

New targets of therapy in T-cell lymphomas

scientific article published on April 2010

Not only TKI! Targeting FLT3-ITD by autophagy

artículo científico publicado en 2016

Outcome of allogeneic hematopoietic cell transplantation after venetoclax and hypomethylating agent therapy for acute myeloid leukemia

scientific article published on 28 August 2020

Outcomes of Allogeneic Hematopoietic Cell Transplantation after Salvage Therapy with Blinatumomab in Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

artículo científico publicado en 2020

Outcomes of Therapy with Venetoclax Combined with A Hypomethylating Agent in Favorable-Risk Acute Myeloid Leukemia

scientific article published on 23 November 2020

Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study

artículo científico publicado en 2005

P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808

artículo científico publicado en 2010

PP2A Activating Drugs (PAD): Anti-Leukemic and Non-Toxic Activity of Two Novel and Non-Immunosuppressive FTY720 Derivatives ⬇️

artículo científico publicado en 2010

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

artículo científico publicado en 2013

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia

scientific article published on 19 June 2019

Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B study

artículo científico publicado en 2008

Patients with chronic lymphocytic leukemia with high-risk genomic features have inferior outcome on successive Cancer and Leukemia Group B trials with alemtuzumab consolidation: subgroup analysis from CALGB 19901 and CALGB 10101.

artículo científico publicado en 2013

Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions ⬇️

scientific article published on 01 July 2020

Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia

artículo científico publicado en 2013

Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders

artículo científico publicado en 2019

Phase 1 Trial of Decitabine and Bortezomib in High Risk Acute Myeloid Leukemia (AML) ⬇️

artículo científico publicado en 2010

Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia

artículo científico publicado en 2002

Phase I Study of Lenalidomide in Acute Leukemia: Remissions in Post-Allogeneic Relapse of Acute Myeloid Leukemia. ⬇️

scholarly article

Phase I Study of Low Dose Decitabine in Patients with Acute Myeloid Leukemia (AML): Pharmacokinetics (PK), Pharmacodynamics (PD), and Clinical Activity. ⬇️

scholarly article

Phase I Trial of Total Marrow and Lymphoid Irradiation Transplantation Conditioning in Patients with Relapsed/Refractory Acute Leukemia

artículo científico publicado en 2017

Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias

artículo científico publicado en 2010

Phase I study of GTI-2040, a ribonucleotide reductase antisense, with high dose cytarabine in patients with relapsed/refractory acute myeloid leukemia

artículo científico publicado en 2013

Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia

artículo científico publicado en 2008

Phase I study of azacitidine and bortezomib in adults with relapsed or refractory acute myeloid leukemia

artículo científico publicado en 2013

Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia

artículo científico publicado en 2007

Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity

artículo científico publicado en 2005

Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: dose-limiting myelosuppression without evidence of DNA hypomethylation

artículo científico publicado en 2010

Philadelphia (Ph) Chromosome (BCR-ABL1 fusion) As a Recurrent Genetic Abnormality Among Therapy-Related Acute Leukemia ⬇️

scholarly article

Philadelphia chromosome as a recurrent event among therapy-related acute leukemia.

artículo científico publicado en 2016

Poor Outcome of RUNX1-Mutated (RUNX1-mut) Patients (Pts) with Primary, Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) and Associated Gene- and MicroRNA (miR) Expression Signatures, ⬇️

artículo científico publicado en 2011

Potential Targeting Ph+ Acute Lymphoblastic Leukemia Stem and Progenitor Cells By Modulating the CIP2A-SET-SETBP1 -Mediated Suppression of PP2A Activity ⬇️

artículo científico publicado en 2016

Potential of microRNAs for cancer diagnostics, prognostication and therapy

artículo científico publicado en 2012

PrEMeR-CG: inferring nucleotide level DNA methylation values from MethylCap-seq data

artículo científico publicado en 2014

Preclinical Development of LNA Antimir-155 (MRG-106) in Acute Myeloid Leukemia ⬇️

artículo científico publicado en 2015

Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia

artículo científico publicado en 2015

Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents

artículo científico publicado en 2016

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

artículo científico publicado en 2012

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias

artículo científico publicado en 2013

Prevention and treatment of cancer-related infections

artículo científico publicado en 2008

Priming of Mir-181a in Acute Myeloid Leukemia (AML) to Increase Chemosensitivity: A Phase I Trial of Lenalidomide (LEN) Followed by Idarubicin and Cytarabine. ⬇️

artículo científico publicado en 2012

Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.

artículo científico publicado en 2006

Prognostic Significance of IDH1 and IDH2 mutations in Older Patients with Primary Cytogenetically Normal Acute Myeloid Leukemia ⬇️

artículo científico publicado en 2016

Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia

artículo científico publicado en 2017

Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study

artículo científico publicado en 2005

Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8.

artículo científico publicado en 2014

Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study

artículo científico publicado en 2009

Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2010

Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia

artículo científico publicado en 2012

Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study

artículo científico publicado en 2008

Proteomic, Gene Expression, and Micro-RNA Analysis Of Bone Marrow Mesenchymal Stromal Cells In Acute Myeloid Leukemia Identifies Pro-Inflammatory, Pro-Survival Signatures In Vitro and In Vivo ⬇️

artículo científico publicado en 2013

Pulmonary hypertension is associated with increased nonrelapse mortality after allogeneic hematopoietic cell transplantation for myelofibrosis

scientific article published on 06 November 2019

Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen

artículo científico publicado en 2011

Quantification of Intracellular Decitabine-Triphosphate with A Novel, Highly Sensitive and Specific LC-MS/MS Assay in Acute Myeloid Leukemia Patients Treated with Low Dose Decitabine. ⬇️

artículo científico publicado en 2009

Quantification of regional DNA methylation by liquid chromatography/tandem mass spectrometry

artículo científico publicado en 2009

Quantification of the Active Decitabine-Triphosphate (DAC-TP) Metabolite: A Novel Pharmacoanalytical Endpoint for Optimization of Hypomethylating Therapy in Acute Myeloid Leukemia (AML) ⬇️

artículo científico publicado en 2012

Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia

artículo científico publicado en 2012

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.

artículo científico publicado en 2017

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

scientific article published on 10 May 2020

RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia

artículo científico publicado en 2012

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures

artículo científico publicado en 2012

Randomized trial of 10 days of decitabine ± bortezomib in untreated older patients with AML: CALGB 11002 (Alliance)

scholarly article published 26 December 2018

ReSETting PP2A Tumor Suppressor Activity Overcomes BCR/ABL Leukemogenic Potential in Blast Crisis CML. ⬇️

artículo científico publicado en 2005

Recombinant interleukin-2 in patients aged younger than 60 years with acute myeloid leukemia in first complete remission: results from Cancer and Leukemia Group B 19808

artículo científico publicado en 2013

Regulation of acute graft-versus-host disease by microRNA-155.

artículo científico publicado en 2012

Reply to "rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases". Haematologica 2014;99(2):e20-21

artículo científico publicado en 2014

Reply to K. Orendi et al

artículo científico publicado en 2013

Requirement of GTP binding for TIF-90-regulated ribosomal RNA synthesis and oncogenic activities in human colon cancer cells

artículo científico publicado en 2020

Response to Venetoclax and Hypomethylating Agents Among Prognostic Risk Groups and Genetic Subtypes of Acute Myeloid Leukemia ⬇️

artículo científico publicado en 2018

Response: Conflicting data on the prognostic significance of FLT3-TKD mutations in cytogenetically normal acute myeloid leukemia (CN-AML) might be related to many factors, including techniques used to detect FLT3-TKD, differences in patient populati

artículo científico publicado en 2008

Retreatment with venetoclax and hypomethylating agents among AML patients who have relapsed after initial response and subsequent interruption of therapy

artículo científico publicado en 2020

Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells.

artículo científico publicado en 2007

Role of the MSC-Derived Exosomal and Endogenous JAK2-SET/PP2A-Beta Catenin-Modulator Mir-300 in Leukemic Stem/Progenitor Proliferation and Survival in CML ⬇️

artículo científico publicado en 2015

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

scientific article published on 23 August 2018

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

artículo científico publicado en 2014

STAT3 Inhibition Enables TLR9-Driven Differentiation of Cbfb/Myh11 acute Myeloid Leukemia Cells to Antigen-Presenting Cell Phenotype In Vivo ⬇️

scholarly article

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

artículo científico publicado en 2013

Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia

artículo científico publicado en 2014

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

artículo científico publicado en 2016

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

artículo científico publicado en 2013

Single Cell Network Profiling as a Platform to Reveal Leukemia-Specific Signaling Signatures and Sensitivity to Kinase Inhibitor Therapies ⬇️

scholarly article

Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13.

artículo científico publicado en 2008

Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia

artículo científico publicado en 2010

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.

artículo científico publicado en 2011

State-transition analysis of time-sequential gene expression identifies critical points that predict development of acute myeloid leukemia

artículo científico publicado en 2020

Statistical methods for detecting differentially methylated regions based on MethylCap-seq data

artículo científico publicado en 2015

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

artículo científico publicado en 2012

Synthetic microRNA cassette dosing: pharmacokinetics, tissue distribution and bioactivity

artículo científico publicado en 2012

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

artículo científico publicado en 2011

TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia

artículo científico publicado en 2009

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

artículo científico publicado en 2014

Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML) ⬇️

artículo científico publicado en 2011

Targeted Delivery of miRNA Antagonists to Myeloid Cells In Vitro and In Vivo

artículo científico publicado en 2019

Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia

artículo científico publicado en 2010

Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia

artículo científico publicado en 2013

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

artículo científico publicado en 2012

Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cells

artículo científico publicado en 2007

Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma

artículo científico publicado en 2008

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

artículo científico publicado en 2020

Targeting Mir-155 via The NEDD8-Activating Enzyme Inhibitor MLN4924: A Novel Therapeutic Approach For Acute Myeloid Leukemia (AML) ⬇️

artículo científico publicado en 2013

Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

artículo científico publicado en 2019

Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia

scientific article published on 23 July 2019

Targeting epigenetic changes in acute myeloid leukemia.

artículo científico publicado en 2005

Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid ⬇️

artículo científico publicado el 29 de septiembre de 2010

Targeting microRNAs in cancer: rationale, strategies and challenges ⬇️

artículo científico publicado el 1 de octubre de 2010

Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia

artículo científico publicado en 2016

The BCR-ABL1-Regulated hnRNP A1, hnRNP E2, and hnRNP K Are Differentially Expressed Between CD34+ and CD34+/CD38- Ph+ Cells, and After Blastic Transformation of CML. ⬇️

artículo científico publicado en 2010

The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML

scientific article published on 08 January 2019

The Clinical Role of Micrornas (miRs) in Cytogenetically Normal (CN) Acute Myeloid Leukemia (AML): miR-155 Upregulation Independently Identifies High-Risk Patients (Pts) ⬇️

artículo científico publicado en 2012

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

artículo científico publicado en 2005

The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele

artículo científico publicado en 2008

The combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide

artículo científico publicado en 2006

The efficacy of venetoclax and hypomethylating agents in acute myeloid leukemia with extramedullary involvement

artículo científico publicado en 2020

The emerging story of acute lymphoblastic leukemia among the Latin American population - biological and clinical implications

scientific article published on 14 August 2018

The feasibility of venetoclax and decitabine in therapy-related acute myeloid leukemia with concurrent advanced non-hematological malignancies

scientific article published on 30 July 2019

The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis

artículo científico publicado en 2011

The role of ErbB3 binding protein 1 in cancer: Friend or foe?

scientific article published on 04 August 2018

The thrombopoietin/MPL/Bcl-xL pathway is essential for survival and self-renewal in human preleukemia induced by AML1-ETO.

artículo científico publicado en 2012

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

artículo científico publicado en 2005

Therapeutic Targeting of the RAS-Pathway by Synthetic Mir-181a Nanoparticles in Acute Myeloid Leukemia (AML). ⬇️

artículo científico publicado en 2012

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

artículo científico publicado en 2013

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

scientific article published on 26 November 2019

Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

scholarly article by Ibrahim Aldoss et al published October 2018 in Haematologica

Time Sequential Transcriptome Analysis Identifies Mir-126 As an Early Biomarker for Inv(16) Acute Myeloid Leukemia (AML) Disease Progression ⬇️

artículo científico publicado en 2016

Transcriptional control of human T-BET expression: the role of Sp1.

artículo científico publicado en 2007

Transcriptome dynamics describe and predict state transition from health to leukemia

article

Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model

artículo científico publicado en 2009

Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.

artículo científico publicado en 2009

Translational Research From the Tropical Forest: Silvestrol, a Natural Product From the Plant Aglaia Foveolata inhibits the Expression of Tyrosine Kinases and Shows a Significant In Vivo Activity in Acute Myeloid Leukemia (AML) ⬇️

scholarly article

Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML

artículo científico publicado en 2021

Tumor intrinsic and extrinsic determinants of response to blinatumomab in adults with B-ALL

artículo científico publicado en 2020

Understanding the molecular basis of imatinib mesylate therapy in chronic myelogenous leukemia and the related mechanisms of resistance. Commentary re: A. N. Mohamed et al., The effect of imatinib mesylate on patients with Philadelphia chromosome-po

artículo científico publicado en 2003

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

artículo científico publicado en 2012

Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia

artículo científico publicado en 2009

Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study

artículo científico publicado en 2012

Venetoclax and hypomethylating agents in FLT3-mutated acute myeloid leukemia

artículo científico publicado en 2020

Venetoclax and hypomethylating agents in TP53-mutated acute myeloid leukaemia

artículo científico publicado en 2019

Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study

artículo científico publicado en 2008

inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations

artículo científico publicado en 2012

miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model

artículo científico publicado en 2012

miR-3151 Interplays With its Host Gene BAALC and Independently Impacts on Outcome of Older Patients With Cytogenetically Normal Acute Myeloid Leukemia by Direct Deregulation of TP53

article

miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia

artículo científico publicado en 2012

miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

artículo científico publicado en 2010

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