Lista de obras -

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

artículo científico publicado en 2013

7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells

artículo científico publicado en 2002

Acrylamide and glycidamide: approach towards risk assessment based on biomarker guided dosimetry of genotoxic/mutagenic effects in human blood

artículo científico publicado en 2005

Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood.

artículo científico publicado en 2005

An Efficient Synthesis of a Lycobetaine-Tortuosine Analogue: A Potent Topoisomerase Inhibitor

An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands

artículo científico publicado en 2006

Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis

artículo científico publicado en 2008

Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines

artículo científico publicado en 2010

Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2.

artículo científico publicado en 2008

Antioxidant‐rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: Results from an intervention study ⬇️

artículo científico publicado el 4 de abril de 2011

Apple juice intervention modulates expression of ARE-dependent genes in rat colon and liver

artículo científico publicado en 2010

Assessing the potential impact on the thyroid axis of environmentally relevant food constituents/contaminants in humans

artículo científico publicado en 2016

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex

artículo científico publicado en 2004

Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in rats ⬇️

artículo científico publicado el 11 de octubre de 2010

Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background

artículo científico publicado en 2017

Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short-term repeated uptake intervention study

artículo científico publicado en 2015

Correction to: Mode of action-based risk assessment of genotoxic carcinogens

artículo científico publicado en 2020

Correction to: Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

scientific article published on 16 September 2020

Dicofol degradation to p,p′-dichlorobenzophenone – A potential antiandrogen ⬇️

artículo científico publicado el 11 de abril de 2011

Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non-malignant and malignant cells of rat origin

artículo científico publicado en 2005

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively‐activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells ⬇️

artículo científico publicado el 16 de noviembre de 2012

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo

artículo científico publicado en 2012

Effects of hemodialysis, dialyser type and iron infusion on oxidative stress in uremic patients

artículo científico publicado en 2004

Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats

artículo científico publicado en 2013

Exposure assessment of process-related contaminants in food by biomarker monitoring

artículo científico publicado en 2018

Fate of 14C-acrylamide in roasted and ground coffee during storage

artículo científico publicado en 2008

Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29.

artículo científico publicado en 2009

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

artículo científico publicado en 2005

Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cells

artículo científico publicado en 2006

Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one

artículo científico publicado en 2008

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

artículo científico publicado en 2017

Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells

artículo científico publicado en 2006

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans

artículo científico publicado en 2009

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling

artículo científico publicado en 2012

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

artículo científico publicado en 2005

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

artículo científico publicado en 2012

Indirubin-3-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

artículo científico publicado en 2012

Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia

artículo científico publicado en 2005

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

artículo científico publicado en 2004

Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase

artículo científico publicado en 2002

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

artículo científico publicado en 2016

Microbial food cultures – opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) ⬇️

artículo científico publicado el 23 de febrero de 2011

Mode of action-based risk assessment of genotoxic carcinogens

artículo científico publicado en 2020

Modulation of 3',5'-cyclic AMP homeostasis in human platelets by coffee and individual coffee constituents

artículo científico publicado en 2014

Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines

artículo científico publicado en 2006

Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine

artículo científico publicado en 2004

N7-Glycidamide-Guanine DNA Adduct Formation by Orally Ingested Acrylamide in Rats: A Dose–Response Study Encompassing Human Diet-Related Exposure Levels ⬇️

artículo científico publicado el 31 de enero de 2012

Natural flavonoids are potent inhibitors of glycogen phosphorylase

artículo científico publicado en 2006

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health

artículo científico publicado en 2014

Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats

artículo científico publicado en 2005

Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells.

artículo científico publicado en 2005

Our senior editors. Gerhard Eisenbrand: food chemistry and environmental toxicology

artículo científico publicado en 2006

Physicochemical characterization and in vitro permeation of an indirubin derivative

artículo científico publicado en 2013

Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines

artículo científico publicado en 2006

Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

artículo científico publicado en 2020

Richard Loeppky (1937–2012) ⬇️

artículo científico publicado el 25 de mayo de 2012

Sensitive in vitro test systems to determine androgenic/antiandrogenic activity

artículo científico publicado en 2004

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

artículo científico publicado en 2010

Synthesis of N-acetyl-S-(3-coumarinyl)-cysteine methyl ester and HPLC analysis of urinary coumarin metabolites

artículo científico publicado en 2003

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

artículo científico publicado en 2012

The health risk of nitrosamines with Gerhard Eisenbrand

artículo científico publicado en 2005

Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide ⬇️

artículo científico publicado el 9 de abril de 2013

Toxicological evaluation of red mould rice

artículo científico publicado en 2006

Update of the toxicological assessment of furanocoumarins in foodstuffs (Update of the SKLM statement of 23/24 September 2004) – Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) ⬇️

artículo científico publicado el 24 de marzo de 2011

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

artículo científico publicado en 2018

Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption

artículo científico publicado en 2018

Lista de obras de

7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells

7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells

Acrylamide and glycidamide: approach towards risk assessment based on biomarker guided dosimetry of genotoxic/mutagenic effects in human blood

Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood.

An Efficient Synthesis of a Lycobetaine-Tortuosine Analogue: A Potent Topoisomerase Inhibitor

An anthocyanin/polyphenolic-rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands

Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis

Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines

Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2.

Antioxidant‐rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: Results from an intervention study ⬇️

Apple juice intervention modulates expression of ARE-dependent genes in rat colon and liver

Assessing the potential impact on the thyroid axis of environmentally relevant food constituents/contaminants in humans

Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex

Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in rats ⬇️

Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background

Coffee consumption rapidly reduces background DNA strand breaks in healthy humans: Results of a short-term repeated uptake intervention study

Correction to: Mode of action-based risk assessment of genotoxic carcinogens

Correction to: Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

Dicofol degradation to p,p′-dichlorobenzophenone – A potential antiandrogen ⬇️

Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non-malignant and malignant cells of rat origin

Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively‐activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells ⬇️

Effect of coffee combining green coffee bean constituents with typical roasting products on the Nrf2/ARE pathway in vitro and in vivo

Effects of hemodialysis, dialyser type and iron infusion on oxidative stress in uremic patients

Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats

Exposure assessment of process-related contaminants in food by biomarker monitoring

Fate of 14C-acrylamide in roasted and ground coffee during storage

Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29.

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors

Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cells

Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans

Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

Indirubin derivatives modulate TGFβ/BMP signaling at different levels and trigger ubiquitin-mediated depletion of nonactivated R-Smads

Indirubin-3-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase

Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Microbial food cultures – opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) ⬇️

Mode of action-based risk assessment of genotoxic carcinogens

Modulation of 3',5'-cyclic AMP homeostasis in human platelets by coffee and individual coffee constituents

Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines

Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine

N7-Glycidamide-Guanine DNA Adduct Formation by Orally Ingested Acrylamide in Rats: A Dose–Response Study Encompassing Human Diet-Related Exposure Levels ⬇️

Natural flavonoids are potent inhibitors of glycogen phosphorylase

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health

Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats

Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells.

Our senior editors. Gerhard Eisenbrand: food chemistry and environmental toxicology

Physicochemical characterization and in vitro permeation of an indirubin derivative

Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines

Revisiting the evidence for genotoxicity of acrylamide (AA), key to risk assessment of dietary AA exposure

Richard Loeppky (1937–2012) ⬇️

Sensitive in vitro test systems to determine androgenic/antiandrogenic activity

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

Synthesis of N-acetyl-S-(3-coumarinyl)-cysteine methyl ester and HPLC analysis of urinary coumarin metabolites

Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs

The health risk of nitrosamines with Gerhard Eisenbrand

Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide ⬇️

Toxicological evaluation of red mould rice

Update of the toxicological assessment of furanocoumarins in foodstuffs (Update of the SKLM statement of 23/24 September 2004) – Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) ⬇️

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption