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Lista de obras de Rolf Larsson

(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities

artículo científico publicado en 2006

1,25(OH)2D3 inhibits hormone secretion and proliferation but not functional dedifferentiation of cultured bovine parathyroid cells

artículo científico publicado en 1988

A Phase I study of CHS 828 in patients with solid tumor malignancy

artículo científico publicado en 2002

A general model for time-dissociated pharmacokinetic-pharmacodynamic relationships exemplified by paclitaxel myelosuppression*

artículo científico publicado el 1 de enero de 1998

A hollow fiber model for in vitro studies of cytotoxic compounds: activity of the cyanoguanidine CHS 828.

artículo científico publicado en 2001

A new fluorometric assay for determination of osteoblastic proliferation: effects of glucocorticoids and insulin-like growth factor-I.

artículo científico publicado en 1997

A non-P-glycoprotein-mediated mechanism of vincristine transport which is affected by resistance modifiers and present in chemosensitive cells

artículo científico publicado en 1994

A pragmatic definition of therapeutic synergy suitable for clinically relevant in vitro multicompound analyses

artículo científico publicado en 2014

A rapid fluorometric method for semiautomated determination of cytotoxicity and cellular proliferation of human tumor cell lines in microculture

artículo científico publicado en 1989

Action of a novel anticancer agent, CHS 828, on mouse fibroblasts: increased sensitivity of cells lacking poly (ADP-Ribose) polymerase-1.

artículo científico publicado en 2002

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

artículo científico publicado en 2013

Activity of CHS 828 in primary cultures of human hematological and solid tumors in vitro

artículo científico publicado en 2001

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

artículo científico publicado en 2003

Activity of standard and investigational cytotoxic drugs in primary cultures of tumor cells from patients with kidney and urinary bladder carcinomas

artículo científico publicado en 1999

Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

artículo científico publicado en 2007

Alpha terpineol: a potential anticancer agent which acts through suppressing NF-kappaB signalling

artículo científico publicado en 2010

Aminopeptidase N (CD13) as a target for cancer chemotherapy

artículo científico publicado en 2011

Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance

artículo científico publicado en 1996

Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity

artículo científico publicado en 2004

Antimicrobial and Antineoplastic Activities of Agelasine Analogs Modified in the Purine 2‐Position ⬇️

artículo científico publicado el 25 de noviembre de 2010

Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs

artículo científico publicado en 2007

Antitumor activity of the alkylating oligopeptides J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester): comparison with melphalan ⬇️

artículo científico publicado el 1 de septiembre de 2003

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-L-melphalanyl-p-L-fluorophenylalanine ethyl ester): comparison with its m-L-sarcolysin analogue P2.

artículo científico publicado en 2003

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo

artículo científico publicado en 2004

Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients

artículo científico publicado en 2000

Apoptosis induced by calcein acetoxymethyl ester in the human histiocytic lymphoma cell line U-937 GTB.

artículo científico publicado en 2000

Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

artículo científico publicado en 2014

Bimodal regulation of secretion by cytoplasmic Ca2+ as demonstrated by the parathyroid

artículo científico publicado en 1987

Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

artículo científico publicado en 2017

Brunn: an open source laboratory information system for microplates with a graphical plate layout design process

artículo científico publicado en 2011

CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo

artículo científico publicado en 1999

Calcium-activated calcium permeability in parathyroid cells

artículo científico publicado en 1986

Calcium-agonistic action of Mn2+ in the parathyroid cell

artículo científico publicado en 1988

Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells

artículo científico publicado en 2001

Cellular cytotoxic drug sensitivity in children with acute leukemia and Down's syndrome: an explanation to differences in clinical outcome?

scientific article published on 01 May 2000

Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage

artículo científico publicado en 2005

Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis(guanylhydrazone).

artículo científico publicado en 2001

Characteristics of etoposide-induced apoptotic cell death in the U-937 human lymphoma cell line

artículo científico publicado en 2001

Characterization and mechanism of formation of reactive products formed during peroxidase-catalyzed oxidation of p-phenetidine. Trapping of reactive species by reduced glutathione and butylated hydroxyanisole.

artículo científico publicado en 1985

Characterization of drug-resistant cell lines by comparative genomic hybridization.

artículo científico publicado en 1999

Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases

artículo científico publicado en 1993

Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

artículo científico publicado en 2008

Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

artículo científico publicado en 2010

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

artículo científico publicado en 2013

Chemotherapeutic drug sensitivity testing of human leukemia cells in vitro using a semiautomated fluorometric assay

artículo científico publicado en 1990

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

artículo científico publicado en 2016

Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines

artículo científico publicado en 2009

Combination of cyclosporin A and buthionine sulfoximine (BSO) as a pharmacological strategy for circumvention of multidrug resistance in small cell lung cancer cell lines selected for resistance to doxorubicin

artículo científico publicado el 1 de enero de 1991

Combination screening in vitro identifies synergistically acting KP372-1 and cytarabine against acute myeloid leukemia

artículo científico publicado en 2016

Comparison of the cytotoxic activity of melphalan with L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine in human tumour cell lines and primary cultures of tumour cells from patients

artículo científico publicado en 1998

Correlation between sensitivity in vitro of patient chronic lymphocytic leukemia cells and clinical systemic exposure at the maximum tolerated dose for cell cycle phase-specific (type 2) anticancer drugs

artículo científico publicado en 1996

Cyanoguanidine CHS 828 induces programmed cell death with apoptotic features in human breast cancer cells in vitro

artículo científico publicado en 2000

Cyclotides: a novel type of cytotoxic agents

artículo científico publicado en 2002

Cytoplasmic Ca2+ concentration of single normal human and bovine parathyroid cells measured by dual wavelength microfluorometry

scientific article published on 01 September 1987

Cytoplasmic pH is differently regulated in the monoblastic U-937 and erythroleukemic K-562 cell lines

artículo científico publicado en 1988

Cytosolic free calcium in platelets: relationships to blood pressure and indices of systemic calcium metabolism.

artículo científico publicado en 1988

Cytotoxic activity of a new lipid formulation of doxorubicin in cell lines and primary tumor cells.

artículo científico publicado en 2002

Cytotoxic activity of a new paclitaxel formulation, Pacliex, in vitro and in vivo

artículo científico publicado en 2004

Cytotoxic activity of calcein acetoxymethyl ester (Calcein/AM) on primary cultures of human haematological and solid tumours

artículo científico publicado en 1996

Cytotoxic activity of cyclosporin A and [3-keto-Bmt 1 ]-[Val 2 ]-cyclosporin (SDZ PSC 833) on tumour cells from patients with haematological malignancies ⬇️

artículo científico publicado el 1 de enero de 1997

Cytotoxic activity of topoisomerase II inhibitors in primary cultures of tumor cells from patients with human hematologic and solid tumors.

artículo científico publicado en 1994

Cytotoxic activity of topotecan in human tumour cell lines and primary cultures of human tumour cells from patients ⬇️

artículo científico publicado el 1 de enero de 1997

Cytotoxic cyclotides from Viola tricolor

artículo científico publicado en 2004

Cytotoxic drug sensitivity testing of tumor cells from patients with ovarian carcinoma using the fluorometric microculture cytotoxicity assay (FMCA).

artículo científico publicado en 1994

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines

artículo científico publicado en 2004

Cytotoxic effect of calcein acetoxymethyl ester on human tumor cell lines: drug delivery by intracellular trapping.

artículo científico publicado en 1995

Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells

artículo científico publicado en 2001

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

artículo científico publicado en 2015

Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism

artículo científico publicado en 1984

Detection of cell aggregation and altered cell viability by automated label-free video microscopy: a promising alternative to endpoint viability assays in high-throughput screening

artículo científico publicado en 2014

Determination of drug effect on tumour cells, host animal toxicity and drug pharmacokinetics in a hollow-fibre model in rats

scientific article published on 01 January 2000

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.

artículo científico publicado en 2004

Development of abnormal parathyroid cell function during monolayer culture and its relation to cellular hypertrophy and proliferation

scientific article published on 01 July 1987

Development of vincristine resistance and increased sensitivity to cyclosporin A and verapamil in the human U-937 lymphoma cell line without overexpression of the 170-kDa P-glycoprotein

artículo científico publicado en 1994

Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids

artículo científico publicado en 2008

Differential activity of Cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro

artículo científico publicado en 1997

Differential activity of topotecan, irinotecan and SN-38 in fresh human tumour cells but not in cell lines

scientific article published on 01 October 2000

Differential in vitro sensitivity of human tumor and normal cells to chemotherapeutic agents and resistance modulators

artículo científico publicado en 1991

Difluoromethylornithine and ethylglyoxal bis(guanylhydrazone) as inhibitors of human renal carcinoma cell proliferation and polyamine metabolism.

artículo científico publicado en 1993

Dimethyl sulfoxide increases cytoplasmic Ca2+ concentration and inhibits parathyroid hormone release in normal bovine and pathological human parathyroid cells

artículo científico publicado en 1987

Dimethyl sulfoxide inhibits proliferation but not hypertrophy and functional dedifferentiation of bovine parathyroid cells in culture

artículo científico publicado en 1988

Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression ⬇️

artículo científico publicado el 1 de diciembre de 1991

Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

artículo científico publicado en 2015

Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

artículo científico publicado en 2013

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

artículo científico publicado en 2015

Dual effects of a new hypocalcemic agent, WR-2721, on cytoplasmic Ca2+ and parathyroid hormone release of dispersed parathyroid cells from patients with hyperparathyroidism

scientific article published on 01 December 1986

Early ionic events associated with phorbol ester induced differentiation and inhibition of cell growth in hematopoietic tumor cell lines

artículo científico publicado en 1989

Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine.

artículo científico publicado en 2000

Effects of calcium channel modulators on the regulation of cytoplasmic Ca2+ and hormone secretion of parathyroid cells

scientific article published on 01 March 1996

Effects of hypoxia on human cancer cell line chemosensitivity

artículo científico publicado en 2013

Effects of interferons and tumour necrosis factor-alpha on human lung cancer cell lines and the development of an interferon-resistant lung cancer cell line

artículo científico publicado en 1996

Effects of lovastatin on a human myeloma cell line: increased sensitivity of a multidrug-resistant subline that expresses the 170 kDa P-glycoprotein.

artículo científico publicado en 1994

Evaluation of drug interactions in the established FEC regimen in primary cultures of tumour cells from patients

artículo científico publicado en 2000

Evaluation of purine and pyrimidine analogues in human tumor cells from patients with low-grade lymphoproliferative disorders using the FMCA.

artículo científico publicado en 1999

Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors.

artículo científico publicado en 1995

Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia ⬇️

artículo científico publicado el 5 de enero de 2011

Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal NETS.

artículo científico publicado en 2018

Expression of the 85-kd membrane protein in primary human breast cancer: relationship to hormone receptor levels, DNA ploidy, and tumor grade

artículo científico publicado en 1995

Expression of the multidrug-resistance gene product in untreated human breast cancer and its relationship to prognostic markers.

artículo científico publicado en 1994

Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) for cytotoxic drug sensitivity testing of tumor cells from patients with acute lymphoblastic leukemia

artículo científico publicado el 1 de noviembre de 1992

Fluoride interactions with stimulus-secretion coupling of normal and pathological parathyroid cells

artículo científico publicado en 1992

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

artículo científico publicado en 2012

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

artículo científico publicado en 2013

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

artículo científico publicado en 2017

Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology

artículo científico publicado en 2001

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

artículo científico publicado en 2010

Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia

artículo científico publicado en 2010

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties ⬇️

artículo científico publicado el 29 de julio de 2011

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

artículo científico publicado en 2009

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

artículo científico publicado en 2005

Image-based screening for the identification of novel proteasome inhibitors

artículo científico publicado en 2007

Imatinib activity in vitro in tumor cells from patients with chronic myeloid leukemia in chronic phase and blast crisis

artículo científico publicado en 2006

In vitro activity of 2-chlorodeoxyadenosine (CdA) in primary cultures of human haematological and solid tumours.

artículo científico publicado en 1994

In vitro activity of bortezomib in cultures of patient tumour cells--potential utility in haematological malignancies

artículo científico publicado en 2008

In vitro activity of imatinib in cells from patients with adult acute lymphoblastic leukemia

artículo científico publicado en 2005

In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia

artículo científico publicado en 2005

In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia

artículo científico publicado en 2002

In vitro analysis of drug resistance in tumor cells from patients with acute myelocytic leukemia.

artículo científico publicado en 1992

In vitro and in vivo activity of melflufen (J1)in lymphoma

artículo científico publicado en 2016

In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia

artículo científico publicado en 2016

In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

artículo científico publicado en 2008

In vitro cytotoxic drug activity and in vivo pharmacokinetics in childhood acute myeloid leukemia.

artículo científico publicado en 1999

In vitro determination of cytotoxic drug response in ovarian carcinoma using the fluorometric microculture cytotoxicity assay (FMCA) ⬇️

artículo científico publicado el 17 de septiembre de 1997

In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

artículo científico publicado en 2015

In vitro drug resistance in B cell chronic lymphocytic leukemia: a comparison with acute myelocytic and acute lymphocytic leukemia

artículo científico publicado en 2005

In vitro drug sensitivity testing of tumor cells from patients with non-Hodgkin's lymphoma using the fluorometric microculture cytotoxicity assay

artículo científico publicado en 1994

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

artículo científico publicado en 2011

In vitro evaluation of new anticancer drugs, exemplified by vinorelbine, using the fluorometric microculture cytotoxicity assay on human tumor cell lines and patient biopsy cells

artículo científico publicado el 1 de septiembre de 1996

In vitro evaluation of the efficacy of idarubicin in human tumour cells from patients with low-grade non-Hodgkin's lymphoma

artículo científico publicado en 2002

In vitro testing of chemotherapeutic drug combinations in acute myelocytic leukaemia using the fluorometric microculture cytotoxicity assay (FMCA).

artículo científico publicado en 1993

In vivo activity of CHS 828 on hollow-fibre cultures of primary human tumour cells from patients

artículo científico publicado en 2001

Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

artículo científico publicado en 2003

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

artículo científico publicado en 2014

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

artículo científico publicado en 2009

Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress

artículo científico publicado en 2013

Inhibition of cell growth retains differentiated function of bovine parathyroid cells in monolayer culture

artículo científico publicado en 1988

Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram

artículo científico publicado en 2006

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

artículo científico publicado en 2011

Interaction of monoclonal antiparathyroid antibody with Ca2+ agonistic actions of Mn2+ in normal human parathyroid cells

scientific article published on 01 January 1989

Interactions between cladribine (2-chlorodeoxyadenosine) and standard antileukemic drugs in primary cultures of human tumor cells from patients with acute myelocytic leukemia.

artículo científico publicado en 1994

Interactions between magnesium and calcium in beta-cell-rich pancreatic islets.

artículo científico publicado en 1983

Interactions between the new cytotoxic drug CHS 828 and amiloride and mitomycin C in a human tumour cell line and in tumour cells from patients

artículo científico publicado en 2002

Is in vitro sensitivity of blast cells correlated to therapeutic effect in childhood acute lymphoblastic leukemia?

artículo científico publicado en 1999

Kinetic evidence for cytoplasmic calcium as an inhibitory messenger in parathyroid hormone release

artículo científico publicado en 1988

Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

artículo científico publicado en 2014

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

artículo científico publicado en 2013

Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA) ⬇️

artículo científico publicado el 21 de enero de 1992

Laboratory prediction of clinical chemotherapeutic drug resistance: a working model exemplified by acute leukaemia

artículo científico publicado en 1993

Lack of relationship between systemic exposure for the component drug of the fluorouracil, epirubicin, and 4-hydroxycyclophosphamide regimen in breast cancer patients

scientific article published on 01 May 1996

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

artículo científico publicado en 2016

Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga

artículo científico publicado en 2002

Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

artículo científico publicado en 2012

Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions

artículo científico publicado en 2017

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

artículo científico publicado en 2017

Melflufen - a peptidase-potentiated alkylating agent in clinical trials

artículo científico publicado en 2017

Metabolic effects of the cytotoxic guanidino-containing drug CHS 828 in human U-937 lymphoma cells.

artículo científico publicado en 2002

Microfluorometric evaluation of calcein acetoxymethyl ester as a probe for P-glycoprotein-mediated resistance: effects of cyclosporin A and its nonimmunosuppressive analogue SDZ PSC 833.

artículo científico publicado en 1994

Model for time dependency of cytotoxic effect of CHS 828 in vitro suggests two different mechanisms of action

artículo científico publicado en 2001

Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

artículo científico publicado en 2007

Modulation of calcium signalling and proliferation in monoblastoid U-937 cells.

artículo científico publicado en 1996

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells

artículo científico publicado en 2002

Modulation of the Ca2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism

scientific article published on 01 February 1988

Modulation of vincristine sensitivity of human kidney tumor cells by pharmacological agents interfering with intracellular signals. No apparent relationship to changes in cytoplasmic Ca2+ or pH.

artículo científico publicado en 1990

Monoclonal anti-parathyroid antibodies interfering with a Ca2+-sensor of human parathyroid cells

scientific article published on 01 March 1987

Monoclonal antiparathyroid antibodies revealing defect expression of a calcium receptor mechanism in hyperparathyroidism

artículo científico publicado en 1988

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

artículo científico publicado en 2010

Normalizing effect of Ca2+ ionophore on cytoplasmic Ca2+ and parathyroid hormone release of dispersed parathyroid cells from patients with hyperparathyroidism

artículo científico publicado en 1986

Novel activity of acriflavine against colorectal cancer tumor cells

artículo científico publicado en 2011

On the mechanism underlying calcein-induced cytotoxicity

artículo científico publicado en 1999

Overview of the clinical efficacy of investigational anticancer drugs

artículo científico publicado en 2003

P-glycoprotein expression and activity of resistance modifying agents in primary cultures of human renal and adrenocortical carcinoma cells.

artículo científico publicado en 1994

Pharmacokinetic models for the saturable distribution of paclitaxel

artículo científico publicado en 1999

Pharmacokinetic-pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model

artículo científico publicado en 2005

Pharmacological modification of multi-drug resistance (MDR) in vitro detected by a novel fluorometric microculture cytotoxicity assay. Reversal of resistance and selective cytotoxic actions of cyclosporin A and verapamil on MDR leukemia T-cells

artículo científico publicado en 1990

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

artículo científico publicado en 2007

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

artículo científico publicado en 2007

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

artículo científico publicado en 2011

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

artículo científico publicado en 2006

Phorbol-ester-induced stable changes in the regulation of DNA synthesis and intracellular pH are accompanied by altered expression of protein kinase C in the monoblastoid cell line U-937

artículo científico publicado en 1988

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

artículo científico publicado en 2013

Polyamines regulate human medullary thyroid carcinoma TT-cell proliferation and secretion of calcitonin and calcitonin gene-related peptide

artículo científico publicado en 1994

Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients ⬇️

artículo científico publicado el 1 de mayo de 2003

Preclinical activity of melflufen (J1) in ovarian cancer

scientific article published on 09 August 2016

Prediction of individual patient response to chemotherapy by the fluorometric microculture cytotoxicity assay (FMCA) using drug specific cut-off limits and a Bayesian model.

artículo científico publicado en 1993

Predictive tests for individualization of pharmacological cancer treatment

artículo científico publicado en 2008

Predictive value of in vitro assessment of cytotoxic drug activity in advanced breast cancer

artículo científico publicado en 2005

Primary lymphocytes as predictors for species differences in cytotoxic drug sensitivity.

artículo científico publicado en 2007

Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney

artículo científico publicado en 1985

R-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells

artículo científico publicado en 2006

Reactive products formed by peroxidase catalyzed oxidation of p-phenetidine

artículo científico publicado en 1984

Regulation of parathyroid hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C

scientific article published on 01 June 1992

Relationship between cytotoxic drug response patterns and activity of drug efflux transporters mediating multidrug resistance

artículo científico publicado en 1998

Relationship between external and cytoplasmic calcium concentrations, parathyroid hormone release and weight of parathyroid glands in human hyperparathyroidism

artículo científico publicado en 1988

Relationship between pharmacokinetic parameters in patients and cytotoxicity in vitro of standard and investigational anticancer drugs

scientific article published on 01 February 1995

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

artículo científico publicado en 2013

Reversal of drug resistance and prediction of the response to cytostatics. Experimental drug therapy for tumors has clinical potential

artículo científico publicado el 18 de diciembre de 1991

SDZ PSC-833--a novel potent in vitro chemosensitizer in multiple myeloma

artículo científico publicado el 1 de diciembre de 1992

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

artículo científico publicado en 2007

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

artículo científico publicado en 2009

Screening for apoptosis--classical and emerging techniques

artículo científico publicado en 2005

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

artículo científico publicado en 2013

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

artículo científico publicado en 2006

Secretory disturbance in hyperplastic parathyroid nodules of uremic hyperparathyroidism: implication for parathyroid autotransplantation

artículo científico publicado en 1988

Selection of chemotherapy by ex vivo assessment of tumor sensitivity to cytotoxic drugs: results of a clinical trial

artículo científico publicado en 2002

Selective cytotoxic activity of cyclosporins against tumor cells from patients with B cell chronic lymphocytic leukemia

artículo científico publicado en 1992

Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts

artículo científico publicado en 2002

Selective sensitivity of solid tumors to suramin in primary cultures of tumor cells from patients ⬇️

artículo científico publicado el 3 de noviembre de 1995

Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

artículo científico publicado en 2008

Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells

artículo científico publicado en 2003

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

artículo científico publicado en 2012

Stimulus-secretion coupling of parathyroid hormone release: studies of 45Ca and 86Rb fluxes

artículo científico publicado en 1985

Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives.

artículo científico publicado en 2003

Synthesis, antimicrobial and antineoplastic activities for agelasine and agelasimine analogs with a beta-cyclocitral derived substituent

artículo científico publicado en 2007

TPA induces cytoplasmic alkalinization in human monoblastic U-937 cells without activation of Na+/H+ exchange

artículo científico publicado en 1987

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

artículo científico publicado en 2012

Targeting tumor cells based on Phosphodiesterase 3A expression

artículo científico publicado en 2017

Temporal effects of the novel antitumour pyridyl cyanoguanidine (CHS 828) on human lymphoma cells

artículo científico publicado en 2001

The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing

artículo científico publicado en 2010

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

artículo científico publicado en 2010

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

artículo científico publicado en 2017

The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro--from cytotoxic synergy to complete inhibition of apoptosis

artículo científico publicado en 2002

The fluorometric microculture cytotoxicity assay

artículo científico publicado en 2008

The mutational landscape in pediatric acute lymphoblastic leukemia deciphered by whole genome sequencing

artículo científico publicado en 2015

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

artículo científico publicado en 2007

The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

artículo científico publicado en 2013

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

artículo científico publicado en 2007

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

artículo científico publicado en 2012

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

artículo científico publicado en 2011

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

artículo científico publicado en 2015

Topoisomerase II-mediated alterations of K562 drug resistant sublines.

artículo científico publicado en 1999

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects

artículo científico publicado en 2017

Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

artículo científico publicado en 2004

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin

artículo científico publicado en 2009

VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia

artículo científico publicado en 2004

Variable p-glycoprotein immunoreactivity unrelated to cytotoxic drug-resistance in-vitro of human adrenocortical carcinoma ⬇️

artículo científico publicado el 1 de septiembre de 1994

Vasoactive intestinal polypeptide stimulates parathyroid hormone release by interaction with cyclic adenosine monophosphate production of bovine parathyroid cells

artículo científico publicado en 1991

Verapamil and cyclosporin A potentiate the effects of chemotherapeutic drugs in the human medullary thyroid carcinoma TT cell line not expressing the 170 kDa P-glycoprotein

artículo científico publicado en 1990

Verapamil and cyclosporin A sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration

artículo científico publicado en 1990

p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line

artículo científico publicado en 2006

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