Lista de obras - Geir Christensen - Dominio Público Uruguay

A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta.

artículo científico publicado en 2011

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

artículo científico publicado en 2015

Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis

artículo científico publicado en 2008

Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice

artículo científico publicado en 2006

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes.

artículo científico publicado en 2011

Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.

artículo científico publicado en 2014

Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice

artículo científico publicado en 2013

Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content

artículo científico publicado en 2011

Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study

artículo científico publicado en 2011

Calcium release units in heart failure: that's about the size of it.

artículo científico publicado en 2012

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis ⬇️

artículo científico publicado el 20 de octubre de 2010

Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium

artículo científico publicado en 2010

Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study

artículo científico publicado en 2017

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

artículo científico publicado en 2010

Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice

artículo científico publicado en 2010

Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure

artículo científico publicado en 2008

Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice

artículo científico publicado en 2005

Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse

artículo científico publicado en 2013

Diagnostic accuracy for heart failure – data from the Akershus Cardiac Examination 2 Study

artículo científico publicado en 2015

Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study

artículo científico publicado en 2018

Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.

artículo científico publicado en 2008

Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure

artículo científico publicado en 2005

Effect of short- and long-term physical activities on circulating granin protein levels

artículo científico publicado en 2013

Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling

artículo científico publicado en 1997

Elevated levels of activin A in clinical and experimental pulmonary hypertension

artículo científico publicado en 2009

Elevated levels of activin A in heart failure: potential role in myocardial remodeling

artículo científico publicado en 2004

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

artículo científico publicado en 2016

Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement

artículo científico publicado en 2012

Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice

artículo científico publicado en 2010

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

scientific journal article

Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study

artículo científico publicado en 2017

Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis

artículo científico publicado en 2017

Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure

artículo científico publicado en 2017

High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2.

artículo científico publicado en 2010

Identifying pathogenic processes by integrating microarray data with prior knowledge

artículo científico publicado en 2014

Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2.

artículo científico publicado en 2014

In memory of Guro Valen (1960-2014).

artículo científico publicado en 2014

Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage

artículo científico publicado en 2014

Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling

artículo científico publicado en 2009

Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling

artículo científico publicado en 2004

Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure

scientific journal article

Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study

artículo científico publicado en 2015

Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload

artículo científico publicado en 2011

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice

artículo científico publicado en 2015

Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes

artículo científico publicado en 2004

Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene

artículo científico publicado en 2013

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.

artículo científico publicado en 2013

Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models

artículo científico publicado en 2009

Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study

artículo científico publicado en 2017

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

artículo científico publicado en 2009

Multiple cytokine biomarkers in heart failure

scientific article published on March 2010

Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure

artículo científico publicado en 2000

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

artículo científico publicado en 2017

No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium

artículo científico publicado en 2012

Overexpression of integrin α11 induces cardiac fibrosis in mice

artículo científico publicado en 2017

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding

artículo científico publicado en 2014

Prognostic Value of Secretoneurin in Critically Ill Patients With Infections

artículo científico publicado en 2016

Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.

artículo científico publicado en 2018

Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study

artículo científico publicado en 2016

Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis

artículo científico publicado en 2014

Psychological distress and mortality in patients with acute dyspnea: data from the Akershus Cardiac Examination (ACE) 2 Study

artículo científico publicado en 2015

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

artículo científico publicado en 2009

Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity

artículo científico publicado en 2002

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

article

SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium

artículo científico publicado en 2013

Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties

artículo científico publicado en 2012

Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling.

artículo científico publicado en 2015

Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure.

artículo científico publicado en 2009

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.

artículo científico publicado en 2015

Sodium accumulation in SERCA knockout-induced heart failure

artículo científico publicado en 2012

Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout

scientific article published on 14 December 2009

Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice

artículo científico publicado en 2015

Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

artículo científico publicado en 2018

Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity

artículo científico publicado en 2013

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.

artículo científico publicado en 2015

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway

artículo científico publicado en 2011

Syndecans in heart fibrosis

artículo científico publicado en 2016

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

artículo científico publicado en 2016

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury

artículo científico publicado en 2013

The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy

artículo científico publicado en 2017

The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure

The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling

article published in 2018

The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure

artículo científico publicado en 2012

The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling

artículo científico publicado en 2014

The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study

artículo científico publicado en 2016

The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.

artículo científico publicado en 2011

Thyroid hormone control of contraction and the Ca(2+)-ATPase/phospholamban complex in adult rat ventricular myocytes

artículo científico publicado en 1999

Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice

artículo científico publicado en 2017

Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy

artículo científico publicado en 2017

Wnt5a is elevated in heart failure and affects cardiac fibroblast function

artículo científico publicado en 2017

Lista de obras de Geir Christensen

A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta.

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis

Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice

Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes.

Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.

Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice

Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content

Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study

Calcium release units in heart failure: that's about the size of it.

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis ⬇️

Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium

Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice

Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure

Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice

Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse

Diagnostic accuracy for heart failure – data from the Akershus Cardiac Examination 2 Study

Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study

Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.

Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure

Effect of short- and long-term physical activities on circulating granin protein levels

Electrical stimulation of adult rat cardiomyocytes in culture improves contractile properties and is associated with altered calcium handling

Elevated levels of activin A in clinical and experimental pulmonary hypertension

Elevated levels of activin A in heart failure: potential role in myocardial remodeling

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis

Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement

Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in mice

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

Fibroblast growth factor 23 in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study

Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis

Glycosylated Chromogranin A: Potential Role in the Pathogenesis of Heart Failure

High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2.

Identifying pathogenic processes by integrating microarray data with prior knowledge

Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2.

In memory of Guro Valen (1960-2014).

Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage

Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling

Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling

Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure

Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus Cardiac Examination 2 Study

Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload

Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice

Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes

Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.

Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models

Mid-regional pro-adrenomedullin in patients with acute dyspnea: Data from the Akershus Cardiac Examination (ACE) 2 Study

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

Multiple cytokine biomarkers in heart failure

Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium

Overexpression of integrin α11 induces cardiac fibrosis in mice

Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding

Prognostic Value of Secretoneurin in Critically Ill Patients With Infections

Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.

Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study

Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis

Psychological distress and mortality in patients with acute dyspnea: data from the Akershus Cardiac Examination (ACE) 2 Study

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium

Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties

Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling.

Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure.

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.

Sodium accumulation in SERCA knockout-induced heart failure

Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout

Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice

Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway

Syndecans in heart fibrosis

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling