Lista de obras - Laurence Hurst - Dominio Público Uruguay

A Novel Gene Controls a New Structure: PiggyBac Transposable Element-Derived 1, Unique to Mammals, Controls Mammal-Specific Neuronal Paraspeckles

artículo científico publicado en 2022

A RCT for assessment of active human-centred learning finds teacher-centric non-human teaching of evolution optimal

scientific article published on 04 December 2020

A mixture of "cheats" and "co-operators" can enable maximal group benefit

artículo científico publicado en 2010

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

artículo científico publicado en 2014

A test of the null model for 5' UTR evolution based on GC content

artículo científico publicado en 2008

A unification of mosaic structures in the human genome

artículo científico publicado en 2003

Active and repressed biosynthetic gene clusters have spatially distinct chromosome states

scientific article published on 03 June 2020

Atypical at skew in Firmicute genomes results from selection and not from mutation

artículo científico publicado en 2011

Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else?

artículo científico publicado en 2005

Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability

artículo científico publicado en 2011

Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution

artículo científico publicado en 2017

Can codon usage bias explain intron phase distributions and exon symmetry?

artículo científico publicado en 2005

Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee.

artículo científico publicado en 2015

Chance and necessity in the evolution of minimal metabolic networks

artículo científico publicado en 2006

Chromatin remodelling is a major source of coexpression of linked genes in yeast

artículo científico publicado en 2007

Clustering of Tissue-Specific Genes Underlies Much of the Similarity in Rates of Protein Evolution of Linked Genes

article

Clustering of housekeeping genes provides a unified model of gene order in the human genome

artículo científico publicado en 2002

Co-expressed yeast genes cluster over a long range but are not regularly spaced

artículo científico

Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes

artículo científico publicado en 2003

Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Species.

artículo científico publicado en 2017

Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights

artículo científico publicado en 2005

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos

artículo científico publicado en 2010

Comparisons of dN/dS are time dependent for closely related bacterial genomes

artículo científico publicado en 2006

Competition between transposable elements and mutator genes in bacteria

artículo científico publicado en 2012

Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance

artículo científico publicado en 2004

Conditional expression explains molecular evolution of social genes in a microbe

artículo científico publicado en 2019

Covert sex ⬇️

artículo científico publicado el 1 de mayo de 1992

Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs

artículo científico publicado en 2015

Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects

artículo científico publicado en 2016

Direct and indirect consequences of meiotic recombination: implications for genome evolution ⬇️

artículo científico publicado el 7 de diciembre de 2011

Dissecting dispensability

artículo científico publicado en 2005

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

artículo científico publicado en 2011

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

artículo científico publicado en 2017

Do Alu repeats drive the evolution of the primate transcriptome?

artículo científico publicado en 2008

Do Wolbachia-associated incompatibilities promote polyandry?

artículo científico publicado en 2007

Does negative auto-regulation increase gene duplicability?

artículo científico publicado en 2009

Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals

artículo científico publicado en 2009

Dosage sensitivity and the evolution of gene families in yeast

artículo científico publicado en 2003

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

artículo científico publicado en 2013

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

artículo científico publicado en 2017

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

artículo científico publicado en 2014

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA ⬇️

artículo científico publicado en 2018

Error prevention and mitigation as forces in the evolution of genes and genomes

article

Estimating the prevalence of functional exonic splice regulatory information

artículo científico publicado en 2017

Evidence against the selfish operon theory

artículo científico publicado en 2004

Evidence for Purifying Selection Against Synonymous Mutations in Mammalian Exonic Splicing Enhancers

article

Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts

artículo científico publicado en 2005

Evidence for a priming effect on maternal resource allocation: implications for interbrood competition.

artículo científico publicado en 2003

Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster

artículo científico publicado en 2007

Evidence for co-evolution of gene order and recombination rate

artículo científico publicado en 2003

Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes

artículo científico publicado en 2008

Evidence for deep phylogenetic conservation of exonic splice-related constraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans.

artículo científico publicado en 2013

Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals

artículo científico publicado en 2005

Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design

artículo científico publicado en 2020

Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity

artículo científico publicado en 2006

Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates

artículo científico publicado en 2009

Evidence that the human X chromosome is enriched for male-specific but not female-specific genes

artículo científico publicado en 2003

Evolutionary Genetics: The silence of the genes ⬇️

artículo científico publicado el 1 de mayo de 1995

Evolutionary and physiological importance of hub proteins

artículo científico publicado en 2006

Evolutionary genomics and the reach of selection

artículo científico publicado en 2009

Evolutionary genomics: A positive becomes a negative

artículo científico publicado en 2009

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

artículo científico publicado en 2014

Exonic Splicing Regulatory Elements Skew Synonymous Codon Usage near Intron-exon Boundaries in Mammals

artículo científico publicado en 2007

Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

artículo científico publicado en 2008

Fundamental concepts in genetics: Genetics and the understanding of selection

artículo científico publicado en 2009

Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction

artículo científico publicado en 2005

Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving.

artículo científico publicado en 2013

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

artículo científico publicado en 2014

Genomic function (communication arising): Rate of evolution and gene dispensability

scientific article published in Nature

Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile

artículo científico publicado en 2004

Great majority of recombination events in Arabidopsis are gene conversion events

artículo científico publicado en 2012

GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution

artículo científico publicado en 2010

Growth effects of uniparental disomies and the conflict theory of genomic imprinting ⬇️

artículo científico publicado el 1 de noviembre de 1997

Hearing silence: non-neutral evolution at synonymous sites in mammals

artículo científico publicado en 2006

How Common Are Intragene Windows with K A > K S Owing to Purifying Selection on Synonymous Mutations?

artículo científico publicado en 2007

How do synonymous mutations affect fitness?

artículo científico publicado en 2007

Human antisense genes have unusually short introns: evidence for selection for rapid transcription

article

Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.

artículo científico publicado en 2005

Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2.

artículo científico publicado en 2006

Identification of two maternal transmission ratio distortion loci in pedigrees of the Framingham heart study

artículo científico publicado en 2013

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

scientific article published on 17 September 2019

Intronic AT Skew is a Defendable Proxy for Germline Transcription but does not Predict Crossing-Over or Protein Evolution Rates in Drosophila melanogaster ⬇️

artículo científico publicado el 12 de octubre de 2010

Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression

artículo científico publicado en 2016

It's easier to get along with the quiet neighbours

artículo científico publicado en 2017

Late replicating domains are highly recombining in females but have low male recombination rates: implications for isochore evolution

artículo científico publicado en 2011

Late-replicating domains have higher divergence and diversity in Drosophila melanogaster

artículo científico publicado en 2011

Leukocyte tyrosine kinase functions in pigment cell development

artículo científico publicado en 2008

Maternally-inherited Grb10 reduces placental size and efficiency

artículo científico publicado en 2009

Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast

artículo científico publicado en 2004

Metabolic trade-offs and the maintenance of the fittest and the flattest

artículo científico publicado en 2011

Monoallelic expression and tissue specificity are associated with high crossover rates

artículo científico publicado en 2009

Mutation rate analysis via parent-progeny sequencing of the perennial peach. I. A low rate in woody perennials and a higher mutagenicity in hybrids.

artículo científico publicado en 2016

Mutation rate analysis via parent-progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation.

artículo científico publicado en 2016

Mystery of the mutagenic male

scientific article published in Nature

Neighboring Genes Show Correlated Evolution in Gene Expression

artículo científico publicado en 2015

Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

artículo científico publicado en 2009

Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation

artículo científico publicado en 2010

Open questions: A logic (or lack thereof) of genome organization ⬇️

artículo científico publicado el 28 de mayo de 2013

Parent-progeny sequencing indicates higher mutation rates in heterozygotes.

artículo científico publicado en 2015

Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity?

artículo científico publicado en 2016

Positive charge loading at protein termini is due to membrane protein topology, not a translational ramp

artículo científico publicado en 2013

Positively charged residues are the major determinants of ribosomal velocity

artículo científico publicado en 2013

Predicting the virulence of MRSA from its genome sequence

artículo científico publicado en 2014

Preliminary Assessment of the Impact of MicroRNA-Mediated Regulation on Coding Sequence Evolution in Mammals

artículo científico publicado en 2006

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

artículo científico publicado en 2014

Protein evolution: causes of trends in amino-acid gain and loss

artículo científico publicado en 2006

Protein rates of evolution are predicted by double-strand break events, independent of crossing-over rates

artículo científico publicado en 2009

Purifying Selection on Exonic Splice Enhancers in Intronless Genes

artículo científico publicado en 2016

Purifying selection on splice-related motifs, not expression level nor RNA folding, explains nearly all constraint on human lincRNAs

artículo científico publicado en 2014

Recent advances in understanding of the evolution and maintenance of sex ⬇️

artículo científico publicado el 1 de febrero de 1996

Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life

artículo científico publicado en 2020

SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity.

artículo científico publicado en 2017

Scientific aptitude better explains poor responses to teaching of evolution than psychological conflicts

article

Sensitivity of Patterns of Molecular Evolution to Alterations in Methodology: A Critique of Hughes and Yeager ⬇️

artículo científico publicado el 1 de octubre de 1998

Sex-ratio adjustment in solitary and social spiders ⬇️

artículo científico publicado el 1 de octubre de 1992

Similar rates but different modes of sequence evolution in introns and at exonic silent sites in rodents: evidence for selectively driven codon usage

artículo científico publicado en 2004

Splicing and the evolution of proteins in mammals

artículo científico publicado en 2007

Still stratus not altocumulus: further evidence against the date/party hub distinction

artículo científico publicado en 2007

Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli

artículo científico publicado en 2009

Stratus not altocumulus: a new view of the yeast protein interaction network

artículo científico publicado en 2006

Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation ⬇️

artículo científico publicado el 17 de marzo de 2011

Teaching genetics prior to teaching evolution improves evolution understanding but not acceptance.

artículo científico publicado en 2017

Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias.

artículo científico publicado en 2017

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

artículo científico publicado en 2015

The architecture of intra-organism mutation rate variation in plants

article

The determinants of gene order conservation in yeasts

artículo científico publicado en 2007

The evolution, impact and properties of exonic splice enhancers

artículo científico publicado en 2013

The evolutionary dynamics of eukaryotic gene order

artículo científico publicado en 2004

The form of a trade-off determines the response to competition

artículo científico publicado en 2013

The impact of the nucleosome code on protein-coding sequence evolution in yeast

artículo científico publicado en 2008

The proteins of linked genes evolve at similar rates

artículo científico publicado en 2000

The signature of selection mediated by expression on human genes

artículo científico publicado en 2003

The small introns of antisense genes are better explained by selection for rapid transcription than by "genomic design"

artículo científico publicado en 2005

The sound of silence

scientific article published in Nature

Timing of Replication Is a Determinant of Neutral Substitution Rates but Does Not Explain Slow Y Chromosome Evolution in Rodents

article

Transcriptional coupling of neighboring genes and gene expression noise: evidence that gene orientation and noncoding transcripts are modulators of noise

artículo científico publicado en 2011

Understanding the limits to generalizability of experimental evolutionary models

artículo científico publicado en 2008

Unique cost dynamics elucidate the role of frameshifting errors in promoting translational robustness

artículo científico publicado en 2010

Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome

artículo científico publicado en 2005

Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs

artículo científico publicado en 2015

Why there is more to protein evolution than protein function: splicing, nucleosomes and dual-coding sequence

artículo científico publicado en 2009

Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution

artículo científico publicado en 2012

Lista de obras de Laurence Hurst

A Novel Gene Controls a New Structure: PiggyBac Transposable Element-Derived 1, Unique to Mammals, Controls Mammal-Specific Neuronal Paraspeckles

A RCT for assessment of active human-centred learning finds teacher-centric non-human teaching of evolution optimal

A mixture of "cheats" and "co-operators" can enable maximal group benefit

A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

A test of the null model for 5' UTR evolution based on GC content

A unification of mosaic structures in the human genome

Active and repressed biosynthetic gene clusters have spatially distinct chromosome states

Atypical at skew in Firmicute genomes results from selection and not from mutation

Biased codon usage near intron-exon junctions: selection on splicing enhancers, splice-site recognition or something else?

Birt Hogg-Dubé syndrome-associated FLCN mutations disrupt protein stability

Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution

Can codon usage bias explain intron phase distributions and exon symmetry?

Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee.

Chance and necessity in the evolution of minimal metabolic networks

Chromatin remodelling is a major source of coexpression of linked genes in yeast

Clustering of Tissue-Specific Genes Underlies Much of the Similarity in Rates of Protein Evolution of Linked Genes

Clustering of housekeeping genes provides a unified model of gene order in the human genome

Co-expressed yeast genes cluster over a long range but are not regularly spaced

Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes

Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Species.

Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos

Comparisons of dN/dS are time dependent for closely related bacterial genomes

Competition between transposable elements and mutator genes in bacteria

Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance

Conditional expression explains molecular evolution of social genes in a microbe

Covert sex ⬇️

Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs

Direct Determination of the Mutation Rate in the Bumblebee Reveals Evidence for Weak Recombination-Associated Mutation and an Approximate Rate Constancy in Insects

Direct and indirect consequences of meiotic recombination: implications for genome evolution ⬇️

Dissecting dispensability

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker

Do Alu repeats drive the evolution of the primate transcriptome?

Do Wolbachia-associated incompatibilities promote polyandry?

Does negative auto-regulation increase gene duplicability?

Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals

Dosage sensitivity and the evolution of gene families in yeast

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses

Engineering of PEDF-Expressing Primary Pigment Epithelial Cells by the SB Transposon System Delivered by pFAR4 Plasmids

Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA ⬇️

Error prevention and mitigation as forces in the evolution of genes and genomes

Estimating the prevalence of functional exonic splice regulatory information

Evidence against the selfish operon theory

Evidence for Purifying Selection Against Synonymous Mutations in Mammalian Exonic Splicing Enhancers

Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts

Evidence for a priming effect on maternal resource allocation: implications for interbrood competition.

Evidence for a trade-off between translational efficiency and splicing regulation in determining synonymous codon usage in Drosophila melanogaster

Evidence for co-evolution of gene order and recombination rate

Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes

Evidence for deep phylogenetic conservation of exonic splice-related constraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans.

Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals

Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design

Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity

Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates

Evidence that the human X chromosome is enriched for male-specific but not female-specific genes

Evolutionary Genetics: The silence of the genes ⬇️

Evolutionary and physiological importance of hub proteins

Evolutionary genomics and the reach of selection

Evolutionary genomics: A positive becomes a negative

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients

Exonic Splicing Regulatory Elements Skew Synonymous Codon Usage near Intron-exon Boundaries in Mammals

Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Fundamental concepts in genetics: Genetics and the understanding of selection

Gametophytic selection in Arabidopsis thaliana supports the selective model of intron length reduction

Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving.

Genomic analysis of isolates from the United Kingdom 2012 pertussis outbreak reveals that vaccine antigen genes are unusually fast evolving

Genomic function (communication arising): Rate of evolution and gene dispensability

Genomic regionality in rates of evolution is not explained by clustering of genes of comparable expression profile

Great majority of recombination events in Arabidopsis are gene conversion events

GroEL dependency affects codon usage--support for a critical role of misfolding in gene evolution

Growth effects of uniparental disomies and the conflict theory of genomic imprinting ⬇️

Hearing silence: non-neutral evolution at synonymous sites in mammals

How Common Are Intragene Windows with K A > K S Owing to Purifying Selection on Synonymous Mutations?

How do synonymous mutations affect fitness?

Human antisense genes have unusually short introns: evidence for selection for rapid transcription

Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.

Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2.